BEIKE NLP at SemEval-2022 Task 4: Prompt-Based Paragraph Classification for Patronizing and Condescending Language Detection

PCL detection task is aimed at identifying and categorizing language that is patronizing or condescending towards vulnerable communities in the general media.Compared to other NLP tasks of paragraph classification, the negative language presented in the PCL detection task is usually more implicit and subtle to be recognized, making the performance of common text-classification approaches disappointed. Targeting the PCL detection problem in SemEval-2022 Task 4, in this paper, we give an introduction to our team's solution, which exploits the power of prompt-based learning on paragraph classification. We reformulate the task as an appropriate cloze prompt and use pre-trained Masked Language Models to fill the cloze slot. For the two subtasks, binary classification and multi-label classification, DeBERTa model is adopted and fine-tuned to predict masked label words of task-specific prompts. On the evaluation dataset, for binary classification, our approach achieves an F1-score of 0.6406; for multi-label classification, our approach achieves an macro-F1-score of 0.4689 and ranks first in the leaderboard

The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats

Background: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. Materials and methods: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs. The rectal, tail, toe, and axilla temperature of the rats were assayed every 3 d. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure were measured via TSE phenoMaster/LabMaster animal monitoring system. Adenosine monophosphate-activated protein kinase, Na+-K+-ATPase, fumarase, pyruvic acid and cyclic adenosine monophosphate/cyclic guanosine monophosphate were determined. Results: The lower levels of triiodothyronine, tetraiodothyronine, and thyrotropin-releasing hormone and the higher level of thyroid stimulating hormone revealed the successful establishment of a hypothyroidism model. Oxygen consumption, carbon dioxide production, heat production, and energy expenditure in the FZ and RG groups were obviously increased. The activity of Na+-K+-ATPase and fumarase in the FZ and RG groups was significantly increased. The cyclic adenosine monophosphate/cyclic guanosine monophosphate level in the FZ and RG groups was increased, while the GL group showed the opposite. Conclusion: Our research provides a new way to explore the efficiency of Chinese medicine on the basis of the relationship between drug property and effects on substance and energy metabolism

Effectiveness of Tagetes patula against chronic nonbacterial prostatitis in rat model

The effectiveness of water decoction of Tagetes patula was studied against the chronic nonbacterial prostatitis in a rat model induced by estradiol  subcuta-neously in a castrated male rat. The low-dose decoction of T. patula  significantly ameliorated the prostatitis. The low-dose of polysaccharide and supernatant constituent of T. patula decreased the levels of IL-1?, TNF-?, PSA, and EGF, and improved the levels of testosterone and dihydrotestosterone in vivo. Further, the chemical study indicated that flavonoids were predominant in the supernatant constituent of T. patula. The flavonoids and polysaccha-rides were the effective constituents against prostatitis and this effect may be mediated by keeping hormone balance and a down-regulation of the in?ammatory mediator level of the prostate. Video Clip of Methodology: 9 min 43 Sec   Full Screen   Alternat

Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects

Black ginseng is a type of processed ginseng that is prepared from white or red ginseng by steaming and drying several times. This process causes extensive changes in types and amounts of secondary metabolites. The chief secondary metabolites in ginseng are ginsenosides (dammarane-type triterpene saponins), which transform into less polar ginsenosides in black ginseng by steaming. In addition, apparent changes happen to other secondary metabolites such as the increase in the contents of phenolic compounds, reducing sugars and acidic polysaccharides in addition to the decrease in concentrations of free amino acids and total polysaccharides. Furthermore, the presence of some Maillard reaction products like maltol was also engaged. These obvious chemical changes were associated with a noticeable superiority for black ginseng over white and red ginseng in most of the comparative biological studies. This review article is an attempt to illustrate different methods of preparation of black ginseng, major chemical changes of saponins and other constituents after steaming as well as the reported biological activities of black ginseng, its major saponins and other metabolites

Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology

The major objective of this study was to investigate the anti-chronic nonbacterial prostatitis (CNP) mechanism of T. patula by metabolomics and network pharmacology. The study demonstrated that the flavonoids and polysaccharides of T. patula could alleviate prostatitis by improving the level of DHT, reducing the secretion of PSA and TNF-α. Besides, both could enhance Na+/K+-ATPase activity, decrease the O2 consumption, CO2 production, heat production, energy expenditure of rats and promote respiratory exchange ratio of rats. Up to 28 potential biomarkers and 8 key metabolic pathways related to the treatment of CNP were elucidated by the metabolomics analysis, including phenylalanine metabolism, taurine and hypotaurine metabolism, tryptophan metabolism etc. Network pharmacology prediction also reflected the potential mechanism was associated with tryptophan metabolism and energy pathway. Generally, the potential anti-CNP mechanism of flavonoids and polysaccharides of T. patula might be through reducing the expression of inflammation factors, adjusting the level of hormone and regulating the amino acid metabolism, energy metabolism and glucose and lipid metabolism

Proteomics Study on Nonallergic Hypersensitivity Induced by Compound 4880 and Ovalbumin

<div><p>Nonallergic hypersensitivity reaction (NHR) accounts for more than 77% of all immune-mediated immediate hypersensitivity reactions and has become a serious threat to public health. Here, proteomics was used to study the NHR mechanism of two typical substances, the compound 4880 and ovalbumin. Twelve different proteins were suggested as potential biomarkers for examining the NHR mechanism, and our results revealed that the mechanism mainly encompassed 2 processes, i.e., generation and effect processes. The generation process could be classified as direct stimulation, complement (classical and alternative), coagulation, kallikrein-kinin, and integrated pathways. Thus glutathione peroxidase 1, terminal complement complex (complement factor 4d and Bb), coagulation 13, kininogen-1, and IgE could be used as candidate biomarkers for the indication of the corresponding pathways respectively, the proteins were further confirmed by ELISA. And the effect process was mainly composed of histamine as well as proteins such as DCD and MYLPF, which could be used as important indices for the symptoms of NHR. Our study differs from previous studies in that C4880 was found to not only be involved in the direct stimulation pathway, but also in the activated complement and kallikrein-kinin pathways through the coagulation pathway. We also report for the first time that ovalbumin-induced NHR could be a combination of the coagulation, classical complement, and integrated pathways.</p></div

The number of distinct peptides identified in a protein.

<p>The peptides were identified using Mascot, based on a 95% confidence level.</p

The histamine, IgE, F13, Kng1, Gpx1, Sc5b9, C4d and Bb levels of BN rats by ELISA assay.

<p>All values are expressed as means ± SD and analyzed through one-way ANOVA followed by Dunnett method to determine significance between the control and experimental groups. Compared to control group, *P<0.05, **P<0.01.</p

Molecular functions of the total proteins.

<p>Molecular functions of the total proteins.</p