17 research outputs found
Non-perturbative QCD amplitudes in quenched and eikonal approximations
Even though approximated, strong coupling non-perturbative QCD amplitudes
remain very difficult to obtain. In this article, in eikonal and quenched
approximations, physical insights are presented that rely on the
newly-discovered property of Effective Locality.Comment: Revised version (28 pages and 1 figure in REVTeX). Follow-up work of
Eur. Phys. J. C65, pp. 395-411 (2010), (arXiv:1204.2038 [hep-ph]), and Ann.
Phys. 327, pp. 2666-2690 (2012), (arXiv:1203.6137 [hep-ph]
D*-->Dpi and D*-->Dgamma decays: Axial coupling and Magnetic moment of D* meson
The axial coupling and the magnetic moment of D*-meson or, more specifically,
the couplings g(D*Dpi) and g(D*Dgamma), encode the non-perturbative QCD effects
describing the decays D*-->Dpi and D*-->Dgamma. We compute these quantities by
means of lattice QCD with Nf=2 dynamical quarks, by employing the Wilson
("clover") action. On our finer lattice (a=0.065 fm) we obtain: g(D*Dpi)=20 +/-
2, and g(D0*D0gamma)=[2.0 +/- 0.6]/GeV. This is the first determination of
g(D0*D0gamma) on the lattice. We also provide a short phenomenological
discussion and the comparison of our result with experiment and with the
results quoted in the literature.Comment: 22 pages, 3 figure
Non-Abelian dynamics and heavy multiquarks, Steiner-tree confinement in hadron spectroscopy
A brief review is first presented of attempts to predict stable multiquark
states within current models of hadron spectroscopy. Then a model combining
flip-flop and connected Steiner trees is introduced and shown to lead to stable
multiquarks, in particular for some configurations involving several heavy
quarks and bearing exotic quantum numbers.Comment: 8 pages, 5 figures, Invited talk at the 21st European Conference on
Few-Body Problems in Physics, Salamanca, Spain, August 29th--September 3rd,
2010, to appear in the Proceedings, ed.~A.~Valcarce et al., to appear in
Few-Body Syste
Specific In Vitro IgM Responses of Human B Cells: A Complex Regulatory Network Modulated by Antigen
Increased citrullination of histone H3 in MS brain and animal models of demyelination:A role for TNF-induced PAD4 translocation
Detection of Single Antibody-Secreting Cells Generated After in Vitro Antigen-Induced Stimulation of Human Peripheral Blood Lymphocytes
Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial
Importance The disease process leading to clinical type 1 diabetes often starts during the first years of life. Early exposure to complex dietary proteins may increase the risk of β-cell autoimmunity in children at genetic risk for type 1 diabetes. Extensively hydrolyzed formulas do not contain intact proteins.
Objective To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of diabetes-associated autoantibodies in young children.
Design, Setting, and Participants A double-blind randomized clinical trial of 2159 infants with HLA-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1078 were randomized to be weaned to the extensively hydrolyzed casein formula and 1081 were randomized to be weaned to a conventional cows’ milk–based formula. The participants were observed to April 16, 2013.
Interventions The participants received either a casein hydrolysate or a conventional cows’ milk formula supplemented with 20% of the casein hydrolysate.
Main Outcomes and Measures Primary outcome was positivity for at least 2 diabetes-associated autoantibodies out of 4 analyzed. Autoantibodies to insulin, glutamic acid decarboxylase, and the insulinoma-associated–2 (IA-2) molecule were analyzed using radiobinding assays and islet cell antibodies with immunofluorescence during a median observation period of 7.0 years (mean, 6.3 years).
Results The absolute risk of positivity for 2 or more islet autoantibodies was 13.4% among those randomized to the casein hydrolysate formula (n = 139) vs 11.4% among those randomized to the conventional formula (n = 117). The unadjusted hazard ratio for positivity for 2 or more autoantibodies among those randomized to be weaned to the casein hydrolysate was 1.21 (95% CI, 0.94-1.54), compared with those randomized to the conventional formula, while the hazard ratio adjusted for HLA risk, duration of breastfeeding, vitamin D use, study formula duration and consumption, and region was 1.23 (95% CI, 0.96-1.58). There were no clinically significant differences in the rate of reported adverse events between the 2 groups.
Conclusions and Relevance Among infants at risk for type 1 diabetes, the use of a hydrolyzed formula, when compared with a conventional formula, did not reduce the incidence of diabetes-associated autoantibodies after 7 years. These findings do not support a benefit from hydrolyzed formula