What We Know About the Genetic Determinants of Human Homosexuality? A Short Review Communication

“Homosexualism”, “sexual orientation disorder”, “egodistonic homosexuality”, “unspecified sexual disorder”, “sexual maturity disorder” and “sexual relationship disorder”. Since 1948, these have been, throughout the history of the Diagnostic and Statistical Manual of Mental Disorders (DCM) and the International Statistical Classification of Diseases and Related Health Problems (ICD), the terms used by the scientific community to categorize the homoaffective spectrum until in 2017, in the face of strong social and academic demand, their complete disengagement from any terminology that categorizes them as physical and/or mental illness. On the other hand, some areas of science have contributed substantially to a better understanding of this subject, such as genetics and epigenetics. Today, although the scientific community still offers some points of resistance, especially in more conservative countries, it is a consensus that since the implementation of the genome project there has been a considerable methodological expansion that has opened new possibilities of studies that have allowed this advance

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Hérnia intrapericárdica transdiafragmática em trauma contuso: relato de caso e revisão da literatura

Os autores apresentam 1 caso de hérnia intrapericárdica transdiafragmática, resultado de trauma contuso e fazem revisão de 37 casos similares. Os traumas, em 71,05%, foram conseqüentes a acidentes de trânsito, com veículos automotores. Os pacientes apresentaram sintomatologia tardia predominante do coração e, também, queixa do aparelho digestivo. Contudo, a insuficiência cardíaca só foi comprovada duas vezes e os sintomas abdominais, na maioria dos casos, foram confirmados pelos sinais de tração, de distensão ou de oclusão gastrointestinal. Com estudos radiográficos contrastados, o diagnóstico foi conclusivo em 28, 94% e houve suspeita de hérnia diafragmática em 55,26% dos casos. O tratamento cirúrgico foi empregado em todos os pacientes, havendo poucas complicações pós-operatórias e apenas 3 (7,89%) óbitos. A junção entre o centro tendíneo diafragmático e o pericárdio basal foi o local comum das roturas em todos os casos e o colo transverso foi a víscera mais herniada. Em alguns casos, as roturas alcançaram as hemicúpulas diafragmáticas, permitindo hérnias também para os espaços pleurais. Hipóteses de existirem coincidentes pontos de enfraquecimento embrionário nas hemicúpulas diafragmáticas, de haver regiões anatômicas centrais frenopericárdicas adelgaçadas e de ocorrer períodos latentes para as formações herniárias, são levantadas com as devidas argumentações. Detalhes seletivos dos exames complementares são apontados no intuito de facilitar o diagnóstico. São realizadas análises sobre a abordagem cirúrgica empregada e apresentadas sugestões quanto ao uso da via abdominal ou torácica

Hérnia intrapericárdica transdiafragmática em trauma contuso: relato de caso e revisão da literatura

Os autores apresentam 1 caso de hérnia intrapericárdica transdiafragmática, resultado de trauma contuso e fazem revisão de 37 casos similares. Os traumas, em 71,05%, foram conseqüentes a acidentes de trânsito, com veículos automotores. Os pacientes apresentaram sintomatologia tardia predominante do coração e, também, queixa do aparelho digestivo. Contudo, a insuficiência cardíaca só foi comprovada duas vezes e os sintomas abdominais, na maioria dos casos, foram confirmados pelos sinais de tração, de distensão ou de oclusão gastrointestinal. Com estudos radiográficos contrastados, o diagnóstico foi conclusivo em 28, 94% e houve suspeita de hérnia diafragmática em 55,26% dos casos. O tratamento cirúrgico foi empregado em todos os pacientes, havendo poucas complicações pós-operatórias e apenas 3 (7,89%) óbitos. A junção entre o centro tendíneo diafragmático e o pericárdio basal foi o local comum das roturas em todos os casos e o colo transverso foi a víscera mais herniada. Em alguns casos, as roturas alcançaram as hemicúpulas diafragmáticas, permitindo hérnias também para os espaços pleurais. Hipóteses de existirem coincidentes pontos de enfraquecimento embrionário nas hemicúpulas diafragmáticas, de haver regiões anatômicas centrais frenopericárdicas adelgaçadas e de ocorrer períodos latentes para as formações herniárias, são levantadas com as devidas argumentações. Detalhes seletivos dos exames complementares são apontados no intuito de facilitar o diagnóstico. São realizadas análises sobre a abordagem cirúrgica empregada e apresentadas sugestões quanto ao uso da via abdominal ou torácica

The Innovation, Networks and Emerging Jobs: A Bibliometric Study Of the Web of Science’s Database, From 1945 To 2020

This research presents a bibliometric study of scientific productions involving the themes of innovation, networks and emerging jobs in the English language, available in the Web of Science’s database, dating from 1945 to 2020. Seeking to clarify some findings, in the statistical study of Web of Science’s publications, this research demonstrates the orientation of the reasoning of the investigated authors, regarding innovation policies. Of the 49 publications found in a previous screening, we obtained the number of 44 publications in English, which were submitted to statistical, Reinert and Similitude analyses, using the IRAMUTEQ software. During the research, it was possible to notice that this group of words presented a relation in the context of the texts available in the base; that is: the tool presented, statistically, four groups of words with greater relevance, connecting the three themes. In the analysis, IRAMUTEQ presented a division in four clusters (using Reinert’s method) that list the groups of words by their relation of higher incidence and correlation during the study (development, literature, information and form). According to this mapping, it is possible to conclude that the correlation of themes refers to a group of researchers who, in their discourses, connect technological and economic development to relations in an innovation network, and that 50% of the published texts dealt with issues involving the four largest groups of words: development, network, innovation and business

Transversal Diagnosis of the Panorama of Professional Education: A Case Study of the City of Itaporã – Mato Grosso do Sul

This case study aims to identify the demand for professional education courses in the city of Itaporã, in the state of Mato Grosso do Sul, in the year 2020, offering a cross-cutting diagnosis of this educational panorama; for this purpose, the technique of guided interview in loco was implemented with the action coordinating agents designated by the municipal administration. All those involved were aware of their free and voluntary collaboration. During the entire collection phase, the information was recorded through a free association chart which, later revised, gave basis to the identification that in the disclosure phase there is no time to contact the possible students taking into account that, besides the districts, the municipality aggregates a vast rural region. In addition, the fact that the course is offered only at night, ends up discouraging the participation of some potential students who, despite showing interest, need to pay attention to their labor routines. It is concluded that a greater concern is needed to create a database of course graduates in order to establish a periodic sense capable of identifying professional life after the course, in addition to profiling the demand for skilled labor in order to detect which training is important at the moment

Discourse Analysis On Physical Activity For People With Disabilities

The subject discussed refers to the importance of physical activity for people with disabilities, both in physical and psychological aspects. The general objective of this work is to identify the relationship of the person with disability to the sport, as guaranteed by the Federal Constitution, giving the person with disability the right to the sport. As a specific objective, to analyze through journalistic texts what is the perception of the person with disability in face of his/her limitations. The methodology used will be an analytical approach, together with bibliographic and documentary research. The relevance for the study of this theme is the look at the person with disability, which is often forgotten by the public power, or pre-judged by the society that most of the times does not know the concept of disability, or when they come across it, they do not know how to act or how to treat a person with disability. Maybe because they don't even know how they think according to their current life condition, as to the difficulties, as to the accessibility, as to the expectations, as to the way they are seen or treated by society. This raises a question: How are people with disabilities treated by society and public authorities? Are their rights being respected? This answer can be traced back to a critical analysis of a person with disability's discourse

The ANALYZING THE APPLICATION OF THE EQUALITY CONCEPT TO INDIGENOUS STATUS IN RELATION TO HUMAN RIGHTS

This article is about the Statute of the Indian from the educational point of view of equality. It aims to approach one of the branches of social rights, regarding education. This education is protected by the 1988 Constitution of the Federative Republic of Brazil and must be provided on an equal basis for students of basic education and indigenous academics. It is a fact that traditional populations, from basic education, receive an education in a different way, because of their language, customs. Based on this premise, the research sought to answer why offer differentiated treatment in basic education (primary and secondary) and not give the necessary support in higher education? In this context, we sought to get to know the reality of the indigenous peoples in terms of education, from the first steps until they entered the University. In addition, factors were pointed out that make it difficult for these scholars to remain in universities and the possible ways to attenuate the existing discrepancies in education and opportunity between indigenous and non-indigenous people. The methodology applied was the bibliographic review, with the use of books, legislation (especially the Statute of the Indian) and articles hosted in online journals. The results showed that despite the advances, there is still a long way to go to achieve an ideal education

Effect of Ischemic Postconditioning and Atorvastatin in the Prevention of Remote Lung Reperfusion Injury

Abstract Objective: The aim of the present study was to evaluate the ability of ischemic postconditioning, atorvastatin and both associated to prevent or minimize reperfusion injury in the lung of rats subjected to ischemia and reperfusion by abdominal aortic clamping. Methods: We used 41 Wistar norvegic rats, which were distributed into 5 groups: ischemia and reperfusion (I/R), ischemic postcondictioning (IPC), postconditioning + atorvastatin (IPC+A), atorvastatin (A) and SHAM. It was performed a medium laparotomy, dissection and isolation of the infra-renal abdominal aorta; except for the SHAM group, all the others were submitted to the aortic clamping for 70 minutes (ischemia) and posterior clamp removal (reperfusion, 70 minutes). In the IPC and IPC+A groups, postconditioning was performed between the ischemia and reperfusion phases by four cycles of reperfusion and ischemia lasting 30 seconds each. In the IPC+A and A groups, preceding the surgical procedure, administration of 3.4 mg/day of atorvastatin was performed for seven days by gavage. After the surgical procedure, the right caudal lobe was removed from the lung for histological study, using tissue injury score ranging from grade 1 (normal tissue) to grade 4 (intense lesion). Results: The mean lung injury was 3.6 in the I/R group, 1.6 in the IPC group, 1.2 in the IPC+A group, 1.2 in the A group, and 1 in the SHAM group (P<0.01). Conclusion: Ischemic postconditioning and atorvastatin were able to minimize lung reperfusion injury, alone or in combination