Evolutionary cell biology: Functional insight from “Endless forms most beautiful”

In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level. However, the model organisms cell biologists generally use include only a tiny fraction of the true diversity of eukaryotic cellular forms. The divergent cellular processes observed in these more distant lineages are still largely unknown in the general scientific community. Despite the relative obscurity of these organisms, comparative studies of them across eukaryotic diversity have had profound implications for our understanding of fundamental cell biology in all species and have revealed the evolution and origins of previously observed cellular processes. In this Perspective, we will discuss the complexity of cell biology found across the eukaryotic tree, and three specific examples of where studies of divergent cell biology have altered our understanding of key functional aspects of mitochondria, plastids, and membrane trafficking

Design and comparison of 11 kV multilevel voltage source converters for local grid based renewable energy systems

Because the availability of renewable energy is highly variable and the power demand by the consumers could have a very different characteristic, it is very desirable to connect a renewable generation system to the grid. In this respect, the 11 kV multilevel Voltage Source Converter (VSC) has no heavy transformer and is the cost effective solution to interfacing a renewable generation system to the local grid directly. This paper presents the design and comparison of a Five-Level Neutral Point Clamped (5L-NPC), a Five-Level Flying Capacitor (5L-FC), a Five-Level Series Connected H-Bridge (5L-SCHB), an Eleven-Level Neutral Point Clamped (11L-NPC), an Eleven-Level Flying Capacitor (11L-FC), and an Eleven-Level Series Connected H-Bridge (5L-SCHB) VSC for an 11 kV local grid based converter. The cost of power semiconductors and capacitors, modulation schemes and harmonic spectra of the converters are the bases for comparison. © 2011 IEEE

Effect of mutual coupling on torque production in switched reluctance motors

In many cases, the normal operation of switched reluctance machines requires excitation of two or more phases simultaneously. When multiple phases are conducting simultaneously, the flux paths from each phase will overlap, which may lead to localized saturation. In such cases, the flux linkage must be considered a function not just of the current in the test winding but of all excited windings. The degree of mutual coupling between phases influences the per-phase magnetization curves and torque characteristics. In machines with even phase numbers, the degree of mutual coupling between phases varies due to discontinuities in the phase polarity arrangement. From nonlinear finite element simulations, it is possible to compare the i - loop diagrams under single-phase and multiphase excitations, and hence the torque produced. The mutual flux linkage from each phase can be calculated separately for each rotor position using the frozen permeability method, to further analyze the mutual coupling effects. For a given excitation current profile, the torque can be maximized by careful arrangement of the phase polarities

Flow dynamics and mixing processes in hydraulic jump arrays: Implications for channel-lobe transition zones

A detailed field investigation of a saline gravity current in the southwest Black Sea has enabled the first complete analysis of three-dimensional flow structure and dynamics of a series of linked hydraulic jumps in stratified, density-driven, flows. These field observations were collected using an acoustic Doppler current profiler mounted on an autonomous underwater vehicle, and reveal that internal mixing processes in hydraulic jumps, including flow expansion and recirculation, provide a previously unrecognised mechanism for grain-size sorting and segregation in stratified density-driven flows. Field observations suggest a newly identified type of hydraulic jump, that is a stratified low Froude number (< 1.5–2) subaqueous hydraulic jump, with an enhanced ability to transport sediment downstream of the jump, in comparison to hydraulic jumps in other subaerial and submarine flows. These novel field data underpin a new process-based conceptual model of channel lobe transition zones (CLTZs) that explains the scattered offset nature of scours within such settings, the temporal variations in infill and erosion between adjacent scours, how bed shear stresses are maintained across the CLTZ, and why the locus of deposition is so far downstream of the scour zone

The CCAP KnowledgeBase : linking protistan and cyanobacterial biological resources with taxonomic and molecular data

Peer reviewe

The inherent instability of leveed seafloor channels

New analytical models demonstrate that under 2 aggradational flow conditions seafloor channel-levee systems are inherently unstable; both channel area and stability necessarily decrease at long timescales. In time such systems must avulse purely through internal (autogenic) forcing. Although autogenic instabilities likely arise over long enough time for additional allogenic forcing to be expected, channel-levee sensitivity to variations in flow character depends on the prior degree of system evolution. Recalibrated modern Amazon Fan avulsion timings are consistent with this model, challenging accepted interpretations of avulsion triggering

First direct measurements of hydraulic jumps in an active submarine density current

For almost half a century, it has been suspected that hydraulic jumps, which consist of a sudden decrease in downstream velocity and increase in flow thickness, are an important feature of submarine density currents such as turbidity currents and debris flows. Hydraulic jumps are implicated in major seafloor processes, including changes from channel erosion to fan deposition, flow transformations from debris flow to turbidity current, and large-scale seafloor scouring. We provide the first direct evidence of hydraulic jumps in a submarine density current and show that the observed hydraulic jumps are in phase with seafloor scours. Our measurements reveal strong vertical velocities across the jumps and smaller than predicted decreases in downstream velocity. Thus, we demonstrate that hydraulic jumps need not cause instantaneous and catastrophic deposition from the flow as previously suspected. Furthermore, our unique data set highlights problems in using depth-averaged velocities to calculate densimetric Froude numbers for gravity currents

Monitoring and damping unbalanced magnetic pull due to eccentricity fault in induction machines: A review

© 2017 IEEE. Condition monitoring can diagnose the inception of fault mechanisms in induction motors, thus avoiding failure and expensive repairs. Therefore, there is a strong need to develop an efficient condition monitoring. The main target is to achieve a relatively low cost and/or non-invasive system which is still powerful in terms of monitoring for online detection of developing faults. The presented paper addresses rotor eccentricity faults and studies conventional monitoring techniques for induction motors. In order to reduce the unbalanced magnetic pull (UMP) in case of an eccentric rotor, the eccentricity-generated additional airgap flux waves should be reduced. The radial forces in an induction motor are calculated, and the characteristics of unbalanced magnetic pull are described

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Tissue progenitor cells are an attractive target for regenerative therapy. In various organs, bone marrow cell (BMC) therapy has shown promising preliminary results, but to date no definite mechanism has been demonstrated to account for the observed benefit in organ regeneration. Tissue injury and regeneration is invariably accompanied by macrophage infiltration, but their influence upon the progenitor cells is incompletely understood, and direct signaling pathways may be obscured by the multiple roles of macrophages during organ injury. We therefore examined a model without injury; a single i.v. injection of unfractionated BMCs in healthy mice. This induced ductular reactions (DRs) in healthy mice. We demonstrate that macrophages within the unfractionated BMCs are responsible for the production of DRs, engrafting in the recipient liver and localizing to the DRs. Engrafted macrophages produce the cytokine TWEAK (TNF-like weak inducer of apoptosis) in situ. We go on to show that recombinant TWEAK activates DRs and that BMC mediated DRs are TWEAK dependent. DRs are accompanied by liver growth, occur in the absence of liver tissue injury and hepatic progenitor cells can be isolated from the livers of mice with DRs. Overall these results reveal a hitherto undescribed mechanism linking macrophage infiltration to DRs in the liver and highlight a rationale for macrophage derived cell therapy in regenerative medicine

Analysis of rectangular EV inductive charging coupler

© 2017 IEEE. The number of commercial electric vehicles has increased significantly in recent years. However, there are still limited recharging facilities for EVs. Wireless charging offers an alternative way to recharge with more flexibility and convenience. The wireless transformer/coupler is the key component in electric vehicle wireless charging. The maximum power transfer capability is limited by the coupler. In order to reach desired power transfer level, the parameters of the wireless transformer should be analyzed. The wireless power transfer system design also requires accurate coupler parameters. In this paper, rectangular pads with different size of ferrite bars were analyzed in finite element analysis software. The prototype was built to valid the simulation result