Pion transition form factor at the two-loop level vis-\`a-vis experimental data

We use light-cone QCD sum rules to calculate the pion-photon transition form factor, taking into account radiative corrections up to the next-to-next-to-leading order of perturbation theory. We compare the obtained predictions with all available experimental data from the CELLO, CLEO, and the BaBar Collaborations. We point out that the BaBar data are incompatible with the convolution scheme of QCD, on which our predictions are based, and can possibly be explained only with a violation of the factorization theorem. We pull together recent theoretical results and comment on their significance.Comment: 10 pages, 4 figures, 3 tables. Presented by the first author at Workshop "Recent Advances in Perturbative QCD and Hadronic Physics", 20--25 July 2009, ECT*, Trento (Italy), in Honor of Prof. Anatoly Efremov's 75th Birthday. v2 wrong reference tag removed. v3 Fig. 4 and Ref. [27] correcte

Endpoint behavior of the pion distribution amplitude in QCD sum rules with nonlocal condensates

Starting from the QCD sum rules with nonlocal condensates for the pion distribution amplitude, we derive another sum rule for its derivative and its "integral" derivatives---defined in this work. We use this new sum rule to analyze the fine details of the pion distribution amplitude in the endpoint region $x\sim 0$. The results for endpoint-suppressed and flat-top (or flat-like) pion distribution amplitudes are compared with those we obtained with differential sum rules by employing two different models for the distribution of vacuum-quark virtualities. We determine the range of values of the derivatives of the pion distribution amplitude and show that endpoint-suppressed distribution amplitudes lie within this range, while those with endpoint enhancement---flat-type or CZ-like---yield values outside this range.Comment: 20 pages, 10 figures, 1 table, conclusions update

Space-Time Clustering and Correlations of Major Earthquakes

Earthquake occurrence in nature is thought to result from correlated elastic stresses, leading to clustering in space and time. We show that occurrence of major earthquakes in California correlates with time intervals when fluctuations in small earthquakes are suppressed relative to the long term average. We estimate a probability of less than 1% that this coincidence is due to random clustering.Comment: 5 pages, 3 figures. Submitted to PR

Fabrication of a planar micro Penning trap and numerical investigations of versatile ion positioning protocols

We describe a versatile planar Penning trap structure, which allows to dynamically modify the trapping conguration almost arbitrarily. The trap consists of 37 hexagonal electrodes, each with a circumcirle-diameter of 300 m, fabricated in a gold-on-sapphire lithographic technique. Every hexagon can be addressed individually, thus shaping the electric potential. The fabrication of such a device with clean room methods is demonstrated. We illustrate the variability of the device by a detailed numerical simulation of a lateral and a vertical transport and we simulate trapping in racetrack and articial crystal congurations. The trap may be used for ions or electrons, as a versatile container for quantum optics and quantum information experiments.Comment: 10 pages, 7 figures, pdflatex, to be published in New Journal of Physics (NJP) various changes according to the wishes of the NJP referees. Text added and moved around, title changed, abstract changed, references added rev3: one reference had a typo (ref 15), fixed (phys rev a 72, not 71

Scrotal metastases from colorectal carcinoma: a case report

A 72-year-old man presented with a two month history of rectal bleeding. Colonoscopy demonstrated synchronous lesions at 3 cm and 40 cm with histological analysis confirming synchronous adenocarcinomata. He developed bilobar hepatic metastases while undergoing neoadjuvant chemoradiotherapy. Treatment was complicated by Fournier's gangrene of the right hemiscrotum which required surgical debridement. Eight months later he re-presented with an ulcerating lesion on the right hemiscrotum. An en-bloc resection of the ulcerating scrotal lesion and underlying testis was performed. Immunohistological analysis revealed metastatic adenocarcinoma of large bowel origin. Colorectal metastasis to the urogenital tract is rare and here we report a case of rectal carcinoma metastasizing to scrotal skin

Genuine Personality Recognition from Highly Constrained Face Images

People are able to accurately estimate personality traits, merely on the basis of \u201cpassport\u201d-style neutral faces and, thus, cues must exist that allow for such estimation. However, up to date, there has been little progress in identifying the form and location of these cues. In this paper we address the problem of inferring true personality traits in highly constrained images using state of art machine learning techniques, in particular, deep networks and class activation maps analysis. The novelty of our work consists in that, differently from the vast majority of the current and past approaches (that refer to the problem of consensus personality rating prediction) we predict the genuine personality based on highly constrained images: the target\u2019s are self ratings on a validated personality inventory and we restrict to passport-like photos, in which so-called controllable cues are minimized. Our results show that self-reported personality traits can be accurately evaluated from facial features. A preliminar analysis on the features activation maps shows promising results for a deeper understanding on relevant facial cues for traits estimation

Pulsed Feedback Defers Cellular Differentiation

Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a deferral time much longer than the cell cycle? Here we study Bacillus subtilis cells that respond to sudden nutrient limitation with multiple rounds of growth and division before differentiating into spores. A well-characterized genetic circuit controls the concentration and phosphorylation of the master regulator Spo0A, which rises to a critical concentration to initiate sporulation. However, it remains unclear how this circuit enables cells to defer sporulation for multiple cell cycles. Using quantitative time-lapse fluorescence microscopy of Spo0A dynamics in individual cells, we observed pulses of Spo0A phosphorylation at a characteristic cell cycle phase. Pulse amplitudes grew systematically and cell-autonomously over multiple cell cycles leading up to sporulation. This pulse growth required a key positive feedback loop involving the sporulation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression. Thus, deferral is controlled by a pulsed positive feedback loop in which kinase expression is activated by pulses of Spo0A phosphorylation. This pulsed positive feedback architecture provides a more robust mechanism for setting deferral times than constitutive kinase expression. Finally, using mathematical modeling, we show how pulsing and time delays together enable “polyphasic” positive feedback, in which different parts of a feedback loop are active at different times. Polyphasic feedback can enable more accurate tuning of long deferral times. Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a “timer” that operates over timescales much longer than a cell cycle

Geography-dependent horizontal gene transfer from vertebrate predators to their prey

Horizontal transfer (HT) of genes between multicellular animals, once thought to be extremely rare, is being more commonly detected, but its global geographic trend and transfer mechanism have not been investigated. We discovered a unique HT pattern of Bovine-B (BovB) LINE retrotransposons in vertebrates, with a bizarre transfer direction from predators (snakes) to their prey (frogs). At least 54 instances of BovB HT were detected, which we estimate to have occurred across time between 85 and 1.3 Ma. Using comprehensive transcontinental sampling, our study demonstrates that BovB HT is highly prevalent in one geographical region, Madagascar, suggesting important regional differences in the occurrence of HTs. We discovered parasite vectors that may plausibly transmit BovB and found that the proportion of BovB-positive parasites is also high in Madagascar where BovB thus might be physically transported by parasites to diverse vertebrates, potentially including humans. Remarkably, in two frog lineages, BovB HT occurred after migration from a non-HT area (Africa) to the HT hotspot (Madagascar). These results provide a novel perspective on how the prevalence of parasites influences the occurrence of HT in a region, similar to pathogens and their vectors in some endemic diseases

QCD sum rules with nonlocal condensates and the spacelike pion form factor

We present a detailed investigation of the spacelike pion's electromagnetic form factor using three-point QCD sum rules that exclusively involve nonlocal condensates. Our main methodological tools are a spectral density which includes $O(\alpha_s)$ corrections, a suitably improved Gaussian ansatz to model the distribution of the average momentum of quarks in the QCD vacuum, and a perturbative scheme that avoids Landau singularities. Using this framework, we obtain predictions for the pion form factor together with error estimates originating from intrinsic theoretical uncertainties owing to the perturbative expansion and the nonperturbative method applied. We also discuss our results in comparison with other calculations, in particular, with those following from the AdS/QCD correspondence. We find good agreement of our predictions with measurements in the range of momenta covered by the existing experimental data between 1-10 GeV$^2$.Comment: 25 pages, 11 figures, 3 tables. v2 Fig. 7 and Ref. [17] corrected. v3 minor typos corrected; matches version published in Phys. Rev. D79 (2009) 09301

Phase I study of dose-escalated paclitaxel, ifosfamide, and cisplatin (PIC) combination chemotherapy in advanced solid tumours

Based on the already known in vitro synergy between paclitaxel (taxol), cisplatin and oxazophosphorine cytostatics and the broad spectrum of activity of the above drugs we sought to evaluate the paclitaxel (taxol)-ifosfamide-cisplatin (PIC) combination in the outpatient setting in individuals with a variety of advanced solid tumours. Cohorts of patients were entered into six successive dose levels (DLs) with drug doses ranging as follows: paclitaxel 135–215 mg m−2day 1 – (1 h infusion), ifosfamide 4.5–6.0 g m−2(total dose) – divided over days 1 and 2, and cisplatin 80–100 mg m−2(total) – divided over days 1 and 2. Granulocyte colony-stimulating factor was given from day 5 to 14. Forty-two patients were entered. Eighteen patients had 2–8 cycles of prior chemotherapy with no taxanes or ifosfamide (cisplatin was allowed). The regimen was tolerated with outpatient administration in 36/42 patients. Toxicities included: grade 4 neutropenia for ≤ 5 days in 27% of cycles; 5 episodes of febrile neutropenia in three patients at DL-III, -V and -VI. Grade 3/4 thrombocytopenia and cumulative grade 3 anaemia were seen in 7% and 13% of cycles respectively. Three cases of severe grade 3 neuromotor/sensory neuropathy were recorded at DL-II, -III, and -V, all after cycle 3. The maximum tolerated dose was not formally reached at DL-V, but because of progressive anaemia and asthenia/fatigue, it was decided to test a new DL-VI with doses of paclitaxel 200 mg m−2, ifosfamide 5.0 g m−2and cisplatin 100 mg m−2; this appeared to be tolerable and is recommended for further phase II testing. The response rate was 47.5% (complete response + partial response: 20/42). The PIC regimen appears to be feasible and safe in the outpatient setting. Care should be paid to neurotoxicity. Phase II studies are starting in non-small-cell lung cancer, ovarian cancer and head and neck cancer at DL-VI. © 2000 Cancer Research Campaig