Research Data Management and the Health Sciences Librarian

Published as Chapter 10 Research Data Management and the Health Sciences Librarian in Health Sciences Librarianship edited by M. Sandra Wood. Chicago: Rowman & Littlefield and the Medical Library Association, 2014. Link to book on publisher\u27s website. All rights reserved by the publishers. PDF of book chapter posted with publisher\u27s permission

Implementing a Case-Based Research Data Management Curriculum

OBJECTIVE: The Lamar Soutter Library of the University of Massachusetts Medical School is working with partner librarians at MBL-WHOI, Northeastern, Tufts and UMass Amherst on a NN/LM NER grant to author online modules and develop additional Research Data Management (RDM) Teaching Cases based on the UMMS/WPI Data Management Frameworks. The goal is to create an online curriculum to support these institution’s researchers’ data management (RDM) practices. METHODS: The criteria for module content were developed by an evaluation expert using the NSF data management plan requirements. To develop additional RDM Teaching Cases librarians conducted semi-structured data interviews with researchers. The librarians transcribed and coded these interviews using a validated RDM planning instrument to categorize the projects’ RDM challenges. The librarians then authored case narratives based on the data interview, highlighting these authentic challenges along with a set of discussion and comprehension questions to support learner outcomes. RESULTS: Currently there are seven modules in addition to the RDM Teaching Cases being authored by the project partners. The first drafts of the Module content and Teaching Cases are due for completion in spring 2013. CONCLUSIONS: A Data Management Curriculum and RDM Teaching Cases will provide libraries with an educational resource for teaching best practices and supporting their student and faculty research. These educational materials will help to provide researchers and future-researchers with valuable lessons to improve the management of their data throughout the stages of their projects, and will encourage them to see the relationships between managing their data and sharing their data in the future

Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus

AIM: To assess tumour regression grade (TRG) and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS: Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005 and 2011 at a single institution were reviewed. Triplet neoadjuvant chemotherapy consisting of platinum, fluoropyrimidine and anthracycline was considered for operable patients (World Health Organization performance status ? 2) with clinical stage T2-4 N0-1. Response to neoadjuvant chemotherapy (NAC) was assessed using TRG, as described by Mandard et al. In addition lymph node downstaging was also assessed. Lymph node downstaging was defined by cN1 at diagnosis: assessed radiologically (computed tomography, positron emission tomography, endoscopic ultrasonography), then pathologically recorded as N0 after surgery; ypN0 if NAC given prior to surgery, or pN0 if surgery alone. Patients were followed up for 5 years post surgery. Recurrence was defined radiologically, with or without pathological confirmation. An association was examined between t TRG and lymph node downstaging with disease free survival (DFS) and a comprehensive range of clinicopathological characteristics.RESULTS: Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years (median follow up: 2.552, 95%CI: 2.022-3.081). There was a 1.8% (n = 4) inpatient mortality rate. One hundred and thirty-six (62.4%) patients received NAC, with 74.3% (n = 101) of patients demonstrating some signs of pathological tumour regression (TRG 1-4) and 5.9% (n = 8) having a complete pathological response. Forty four point one percent (n = 60) had downstaging of their nodal disease (cN1 to ypN0), compared to only 15.9% (n = 13) that underwent surgery alone (pre-operatively overstaged: cN1 to pN0), (P < 0.0001). Response to NAC was associated with significantly increased DFS (mean DFS; TRG 1-2: 5.1 years, 95%CI: 4.6-5.6 vs TRG 3-5: 2.8 years, 95%CI: 2.2-3.3, P < 0.0001). Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC (median DFS; TRG 3-5 and nodal down-staging: 5.533 years, 95%CI: 3.558-7.531 vs TRG 3-5 and no nodal down-staging: 1.114 years, 95%CI: 0.961-1.267, P < 0.0001).CONCLUSION: Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS

A Sample of Research Data Curation and Management Courses

Objective This paper identifies a sample of research data curation and management courses available at American Library Association-accredited Library and Information Science (LIS) Programs in North America. Methods This sample was identified through a content analysis of LIS program course descriptions and syllabi (N=58). Using a framework of research data management and curation competencies, the team gathered a sample of research data curation and management courses offered between fall 2011 and summer 2012. Results Only 13 (22%) of LIS programs currently offer a course focused on the management and curation of research data. Conclusion Although the literature supports LIS professionals adopting new roles and engaging in eScience and data management, most LIS data-related programs do not have a separate course solely focused on research data management. More LIS programs will need to adapt their curricula in order to help students and practicing professionals develop the needed competencies in research data curation and management

Building an eScience Thesaurus for Librarians: A Collaboration Between the National Network of Libraries of Medicine, New England Region and an Associate Fellow at the National Library of Medicine

Objective: In response to the growing interest and adoption of eScience roles by librarians, those from the National Network of Libraries of Medicine, New England Region (NN/LM NER) and an Associate Fellow from the National Library of Medicine collaborated to build an eScience Thesaurus. The Thesaurus will introduce librarians to terminology and concepts in eScience, point to relevant literature and resources on data and digital research topics, and provide links to interviews with librarians and experts working in eScience-related roles. The eScience Thesaurus is a starting place for librarians to find the vocabulary to research the background, resources, and tools necessary for developing their capacity to provide eScience-related services. Methods: The Associate Fellow completed a review of eScience-related literature to identify the seminal publications for the originations of these terms and concepts as they apply to libraries. Next, the Associate Fellow worked with the NN/LM NER to compile an environmental scan of resources that would be useful and applicable for librarians, and created a scope document and record structure. The team interviewed prominent librarians working in eScience roles and experts that have created digital tools and services used by the library community. Finally, the team sent the Thesaurus records out to five members of the advisory and editorial review boards from the eScience Portal for New England Librarians for evaluation. Results: The eScience Thesaurus is now hosted on the eScience Portal for New England Librarians’ website. It provides a comprehensive list of more than 50 different terminologies and concepts, with links to seminal and relevant literature, resources, grants, and interviews on a variety of eScience-related topics. Conclusion: The eScience Thesaurus is an evolving resource; as the field expands and more eScience-related terms are adopted by the library and information science community, the Portal will enable its users to electronically submit new vocabulary and records to the Thesuarus, thus preserving it as a go-to eScience resource for librarians

Changes in fatty acid composition of human milk in response to cold-like symptoms in the lactating mother and infant

Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This preliminary study investigates whether the proportions of FA in HM change in response to infections, leading to cold-like symptoms in the mother or infant. Milk samples were obtained from mothers (n = 26) when they and their infants were healthy, and when mother, infant, or both suffered cold-like symptoms. The milk was hydrolysed and FA proportions were measured using gas chromatography. Fifteen FAs were recorded, of which eight were detected in sufficient quantities for statistical analysis. The proportions of capric (C10:0) and lauric acids (C12:0) in HM were significantly lower, and palmitic acid (C16:0) was higher when mothers and infants were ill compared to healthy samples. Palmitoleic (C16:1, n-7) and stearic acid (C18:0) proportions were higher in HM when the infant was unwell, but were not related to maternal health. Whilst the differences detected were small (less than 0.5%), the effects may be additive and potentially have a protective function. The value of further studies is certainly indicated

Scanning the Data Environment at the University of Massachusetts Medical School

Objective Environmental scanning constitutes a primary mode of organizational learning” (Choo 1999). In a step toward active development of research data support services for its community, the Lamar Soutter Library at the University of Massachusetts Medical School has undertaken extensive environmental scanning to better understand the strengths, weaknesses, opportunities and challenges of an academic biomedical institution with respect to research data. Given the variety of potential data services that an academic library may deploy, the information gathered from these activities will identify and prioritize new library activities. Method Environmental scanning activities include a survey of student’s experiences and attitudes with research data management; faculty and administrator interviews (via the DuraSpace 2014 eScience Institute program); and the identification of existing local services and policy documents related to research data. Results from these activities are analyzed by the Library Data Services Advisory Group and the eScience Institute working group to plot a formal roadmap for library-based data services. Results Students, faculty, administrators, and existing documentation together reveal a variety of attitudes, assumptions, and avenues for the handling of research data on campus. They identify potential activities where the library might play a role, some expected and some unexpected. Conclusion Information gathered during environmental scanning activities at the University of Massachusetts Medical School informs the development and prioritization of library-based research data support services

Physical activity and risk of inflammatory bowel disease: prospective study from the Nurses’ Health Study cohorts

Objective: To examine the association between physical activity and risk of ulcerative colitis and Crohn’s disease. Design: Prospective cohort study. Setting: Nurses’ Health Study and Nurses’ Health Study II. Participants: 194 711 women enrolled in the Nurses’ Health Study and Nurses’ Health Study II who provided data on physical activity and other risk factors every two to four years since 1984 in the Nurses’ Health Study and 1989 in the Nurses’ Health Study II and followed up through 2010. Main outcome measure Incident ulcerative colitis and Crohn’s disease. Results: During 3 421 972 person years of follow-up, we documented 284 cases of Crohn’s disease and 363 cases of ulcerative colitis. The risk of Crohn’s disease was inversely associated with physical activity (P for trend 0.02). Compared with women in the lowest fifth of physical activity, the multivariate adjusted hazard ratio of Crohn’s disease among women in the highest fifth of physical activity was 0.64 (95% confidence interval 0.44 to 0.94). Active women with at least 27 metabolic equivalent task (MET) hours per week of physical activity had a 44% reduction (hazard ratio 0.56, 95% confidence interval 0.37 to 0.84) in risk of developing Crohn’s disease compared with sedentary women with 0.35). Conclusion: In two large prospective cohorts of US women, physical activity was inversely associated with risk of Crohn’s disease but not of ulcerative colitis

Obligations of Researchers and Managers to Respect Wetlands: Practical Solutions to Minimizing Field Monitoring Impacts

Research and field monitoring can disturb wetland integrity. Adoption of ethical field practices is needed to limit monitoring induced stressors such as trampling, non-native seed and invertebrate dispersal, and disease and fungal spread. We identify a linear pathway of deterioration highlighting stressors that can progress to cumulative impacts, consequences, and losses at the site scale. The first step to minimize disturbance is to assess and classify the current ecosystem quality. We present a tiered framework for wetland classification and link preventative measures to the wetland tier. Preventative measures are recommended at various intensities respective to the wetland tier, with higher tiered wetlands requiring more intense preventative measures. In addition, preventative measures vary by time of implementation (before, during, and after the wetland visit) to mitigate impacts at various temporal scales. The framework is designed to increase transparency of field monitoring impacts and to promote the adoption of preventative measures. Implementing preventative measures can build accountability and foster a greater appreciation for our roles as researchers and managers in protecting wetlands