Hazard ratio for clinical outcome according to QRS-T angle levels by Cox regression analysis.

<p>Hazard ratio for clinical outcome according to QRS-T angle levels by Cox regression analysis.</p

Predictors of mortality by Cox regression analysis.

<p>Predictors of mortality by Cox regression analysis.</p

Relation between QRS-T angle and left ventricular systolic function.

<p><b>(A)</b> Scatter plot demonstrating an inverse linear relation between QRS-T angle and left ventricular ejection fraction. Linear regression: R² = 0.103, B = -1.06, Standard error 0.11, P<0.0001. <b>(B)</b> Box plot of the median QRS-T angle stratified according to the left ventricular ejection fraction. Median QRS-T angle was wider with reduction in left ventricular ejection fraction (Kruskal Wallis test; P<0.001). Box plots denote median and inter-quartile range (IQR); whiskers are of maximum 1.5 IQR.</p

DataSheet1_The effect of statins exposure during pregnancy on congenital anomalies and spontaneous abortions: A systematic review and meta-analysis.docx

Objective: To assess the effect of statin exposure during pregnancy on congenital anomalies and spontaneous abortions.Data sources: Electronic databases were searched from inception to January 2022.Study Eligibility Criteria: Cohort studies and randomized controlled trials (RCTs) evaluate the effect of treatment with statins on congenital anomalies in general and cardiac malformations in particular. Studies evaluating spontaneous abortions were included as a secondary outcome.Study appraisal and synthesis methods: Pooled odds ratio was calculated using a random-effects model and meta-regression was utilized when applicable.Results: Twelve cohort studies and RCTs were included in the analysis. Pregnancy outcomes of 2,447 women that received statins during pregnancy were compared to 897,280 pregnant women who did not. Treatment with statins was not associated with a higher risk of overall congenital anomalies (Odd Ratio = 1.1, CI (0.9–1.3), p = 0.33, I2 = 0%). Yet, cardiac malformations were more prevalent among neonates born to statins users (OR = 1.4, CI (1.1–1.8), p = 0.02, I2 = 0%). The risk was higher when exposure occurred during the first trimester. This finding was statistically significant in cohort studies, but not in RCTs. Statin treatment was also associated with a higher rate of spontaneous abortions (OR = 1.5, CI (1.1–2.0), p = 0.005, I2 = 0%). In meta-regression analysis, no significant association between lipophilic statins and the rate of congenital anomalies was found.Conclusion: Overall, treatment with statins during pregnancy was not associated with an increased risk of congenital anomalies. A slight risk elevation for cardiac malformation and spontaneous abortions was seen in cohort studies but not in RCTs.Systematic Review Registration:clinicaltrials.gov, identifier [CRD42020165804 17/2/2020]The meta-analysis was presented online at 42nd annual meeting of SMFM. January 31-5 February 2022.</p

Changes in the QRS-T angle.

<p>Histogram of the QRS-T angle difference in degrees between baseline and follow-up ECG. The continuous line denotes the normal distribution curve.</p

Kaplan Meier survival analysis according to baseline QRS-T angle category stratified by gender.

<p>The tertile QRS-T angle percentiles were 40° and 103° in women and 51° and 125° in men. The estimated cumulative survival rate at the median follow-up time was reduced with increasing baseline QRS-T angle category; 67.9±1.5% vs. 61.2±1.5% vs. 52.1±1.6%, P<0.001.</p

Hazard ratio for mortality according to the difference in QRS-T angle between follow-up and baseline ECG by Cox regression analysis.

<p>Hazard ratio for mortality according to the difference in QRS-T angle between follow-up and baseline ECG by Cox regression analysis.</p

Widening of the QRS-T angle on follow-up was associated with increased mortality.

<p><b>(A)</b> Kaplan Meier survival analysis according to QRS-T angle change calculated by the difference between follow-up and baseline ECG. An increase in the QRS-T angle on follow-up above 30° was associated with an increased mortality. The estimated cumulative survival rate at the median follow-up time of 342 days was reduced with an increased QRS-T angle difference; 61.9±1.5% vs 63.6±1.9% vs. 53.3±2.0%, Log rank P<0.00001. <b>(B)</b> Cox regression analysis with adjusted hazard ratio for mortality (with 95% confidence interval) of the QRS-T angle change as a continuous variable using restricted cubic splines with 3 knots at the 5^th, 50^th and 95^th percentiles of the QRS-T angle change distribution, P<0.0001. Parameters included were parameters outlined in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0194520#pone.0194520.t003" target="_blank">Table 3</a> with the addition of baseline QRST-T angle.</p

Additional file 1 of Municipal community centers as healthy settings: evaluation of a real-world health promotion intervention in Jerusalem

Additional file1: Appendix A. “Community center for the promotion of good health” agreement. Supplemental material table 1. Curriculum outline of training seminar, year 1.  Supplemental material table 2. District municipal community centers’ health initiatives

Supplementary_appendix – Supplemental material for Gender Differences in Efficacy and Safety of Direct Oral Anticoagulants in Atrial Fibrillation: Systematic Review and Network Meta-analysis

<p>Supplemental material, Supplementary_appendix for Gender Differences in Efficacy and Safety of Direct Oral Anticoagulants in Atrial Fibrillation: Systematic Review and Network Meta-analysis by Bruria Hirsh Raccah, Amichai Perlman, Donna R. Zwas, Sarit Hochberg-Klein, Reem Masarwa, Mordechai Muszkat and Ilan Matok in Annals of Pharmacotherapy</p