Organisms tested in analytical studies.

The four core organisms are shown in bold, with LODs in blood and buffer shown in parentheses (blood LOD in CFU per ml / buffer LOD in CFU per ml). The LOD of 19 further organisms in buffer are also shown in parentheses. Remaining organisms shown in blue and purple were tested and detected in 2/2 replicates at either 100 CFU/ml (all except Bacteroides fragilis) or 200 CFU/ml (Bacteroides fragilis). *Indicates bioinformatic “worst-case scenario” organisms, for which the broad-spectrum primers used in the IRIDICA BAC BSI Assay are the least well-matched.</p

Detailed results from samples with additional detections.

<p>Detailed data from all samples yielding unmatched positive results by either culture or IRIDICA BAC BSI Assay analysis in the presence of matched or unmatched detections by the other technology (additional detections). The matched positive results shown here in the second column are also represented in Tables <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0158186#pone.0158186.t003" target="_blank">3</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0158186#pone.0158186.t004" target="_blank">4</a>, while the additional detections shown here in the rightmost two columns are not, because they have no valid comparator. See discussion of additional detections in text.</p

Comparison of positive IRIDICA BAC BSI Assay and standard-of-care culture results in clinical blood specimens from patients with suspected bloodstream infections, by organism.

<p>Possible identities of ambiguous IRIDICA BAC BSI Assay detections are separated by semicolons in cases where insufficient data was captured to provide species-level identification, and by slashes if the indicated organisms share identical reference signatures and cannot be discriminated. Commas separate multiple independent detections. These indicators are shown as they were reported by the IRIDICA BAC BSI Assay.</p

Comparison of IRIDICA BAC BSI Assay and standard-of-care culture results in clinical blood specimens from patients with suspected bloodstream infections, summarized by organism group (details in Table 4).

<p>Comparison of IRIDICA BAC BSI Assay and standard-of-care culture results in clinical blood specimens from patients with suspected bloodstream infections, summarized by organism group (details in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0158186#pone.0158186.t004" target="_blank">Table 4</a>).</p

Antibiotic resistance marker results summary.

<p>Antibiotic resistance marker results summary.</p

Assay reproducibility at 3X LOD.

<p>Assay reproducibility at 3X LOD.</p

Potentially interfering substances.

<p>Potentially interfering substances.</p