Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs: A Case Report

Polymyxins B and E (colistin) exert a bactericidal effect on the gram-negative bacterial cell wall, causing permeability changes in the cytoplasmic membrane, leading to cell death. Their use was substantially decreased in clinical practice from the 1970s to 2000s due to their significant nephrotoxicity and neurotoxicity compared to the newly introduced antibiotics. The increasing prevalence of multidrug-resistant gram-negative bacteria infections in this century has led to an upsurge in the use of these “older” drugs. Respiratory paralysis caused by neuromuscular blockage associated with the use of polymyxin B and E was reported mostly in literature published in the 1960s to 1970s with a few reports after 2000. In addition, such a reaction might be enhanced by the presence of other classes of drugs. We report a case of polymyxin B and E–induced apnea in a patient receiving “muscle relaxants.

Assessment of health sciences and science and technology librarian e-science educational needs to develop an e-science web portal for librarians

In the summer of 2009, the Lamar Soutter Library at the University of Massachusetts Medical School applied for and was awarded funding from the National Network of Libraries of Medicine, New England Region (NN/LM NER), to begin the construction of an e-science educational web portal specifically for librarians. The e-science web portal team\u27s first task was to assess the region\u27s health sciences and science and technology librarians and their e-science needs and learner preferences in order to help guide and inform the construction of the portal. The objectives of this assessment were threefold. The first was to establish that there was indeed a need for an e-science portal for librarians. The second was to examine what types of e-science and data services were being undertaken by these librarians and their libraries in New England. The third was to identify the background of the region\u27s health sciences and science and technology librarians as well as their educational needs and Web 2.0 tool preferences in order to develop the scope and transmission mechanism of online educational materials concerning e-science. Using feedback from librarian interviews from attendees of an e-science symposium and boot-camp, we researched and developed questions to survey learner needs. The results of the survey clearly show that a small, but significant number of New England libraries serving the health sciences are currently engaged in e-science activities within their institutions or with other institutions and that a larger group of health sciences and science and technology librarians see potential for e-science collaborations in the future. These results, from a sizeable representative sample of respondents, clearly establish that an e-science web portal specifically for librarians is both wanted and needed by New England\u27s library community. These results also show a regional demand for a portal centralizing e-science and data services tools and scientific content tutorials to serve patrons in basic as well as emerging information technology and data-intensive scientific disciplines. Moreover, the results present a community that is comfortable utilizing a variety of educational Web 2.0 tools for its self-guided learning and that is interested in future continuing education and professional development opportunities focusing on e-science

Data Curation and Management Competencies of New England Region Health Sciences and Science and Technology Librarians

Objective: To identify specific data curation and management competencies that would aid in the continued development of a data management curriculum and professional development supporting New England health sciences and science and technology librarians, and to gather data on the nature and progress of data services being provided by these librarians and those being demanded by their patrons. Methodology: Based on a content analysis of data services and e-science librarian job postings, selected library and information science schools¹ programs and curricula, and published case studies and related best practices, the team researched and developed questions for the survey. An assessment was created using SurveyMonkey. A small group of medical librarians tested the survey and offered feedback. The survey was revised and then disseminated to New England health sciences and science and technology librarians. After three weeks, the team collected and analyzed the results. Results and Conclusion: A quarter of respondents surveyed stated that they are already managing and curating data sets. This number has nearly doubled since the team\u27s 2009 assessment of New England health sciences and science and technology librarians engaged in e-science. Almost half of respondents will be providing these services in the future; almost three quarters of respondents stated their library has or is in the process of creating a data management policy. Their responses to the competencies suggest that the portal curriculum focus on technical resources that would develop librarians¹ competencies in data literacy, curation and management by teaching skills such as scripting and programming languages and metadata and interoperability standards, as well as skills necessary to administer an institutional data repository. The data also suggest that a curriculum provide resources that address the non-technical competencies necessary to develop a data management policy, understand intellectual property and scholarly communication related to data. This research is helping the University of Massachusetts Medical School Lamar Soutter Library and National Network of National Libraries of Medicine New England Region (NN/LM NER) to develop its E-Science Portal data management curriculum and in-person professional development programming for its regional librarians engaged in e-science activities. In addition, this assessment illuminates the many challenges that health sciences libraries in New England are facing trying to engage in e-science. Thus, an area for future investigation is the strategies that libraries are using to deal with these challenges and overcome these obstacles

An Assessment of Needed Competencies to Promote the Data Curation and Management Librarianship of Health Sciences and Science and Technology Librarians in New England

Purpose: The purpose of this study was to evaluate health sciences and science and technology librarians’ needed data curation and management (DCM) competencies to support nascent and future patron and institutional eScience research endeavors. The data from this research will be used to align a data curation and management curriculum with the educational needs of an online eScience portal community of users, and create relevant future professional development for librarians interested in data curation and eScience librarianship. Setting/Participants: The study targeted the needed data curation and data management competencies of health sciences and science and technology librarians in six U.S. states who are on a listserv of librarians interested in learning about eScience. The sample for this study was 63 librarians. Methodology: The team created the assessment tool using content analyses of digital curation and management library literature and LIS data management curricula. The survey contained 15 open-ended and closed-ended questions and was distributed to 141 librarians using Survey- Monkey (http://www.surveymonkey.com). Results/Outcomes: The team identified twenty needed competency areas related to data curation and data management. The participants identified the necessary competencies to provide data curation and data management services. Results revealed a small number of librarians engaged in DCM and infrequent data services requests. Findings suggest there is an increase in libraries pursuing strategic plans concerning data management and the library community needs to cultivate a diverse range of technical and non-technical competencies through future professional development. Librarians saw their future roles involving DCM and sought competencies in conducting data interviews with patrons and helping patrons with NSF data management requirements. The survey results indicate the greatest need for librarians is technical hands-on training in the digital description and curation of large data sets. Discussion/Conclusion: Librarians are interested in developing data curation and data management competencies to support eScience. These data indicate that future relevant professional development for librarians interested in eScience should focus on non-technical and technical DCM competencies

Frameworks for a Data Management Curriculum for Science, Health Sciences, and Engineering Students

Objectives: This poster illustrates the Frameworks for a Data Management Curriculum intended for undergraduate and graduate students studying science, health sciences, and engineering disciplines. Methods: An Education Committee composed of librarians, faculty, a curriculum consultant, an evaluation consultant, and an instructional design consultant collaborated in the development of these frameworks. At the two partnering schools, consultants collected data from students regarding their current data management practices and interviewed faculty about their students\u27 data management skills and learning needs. A literature review of current data management courses was conducted. From these resources learning objectives were identified, a simplified data management plan was developed, and a lesson plans for seven course modules were created. The evaluation consultant and an Education Committee librarian interviewed faculty to develop real-life research case scenarios that illustrate data management practices in the lab and clinical settings. Results: The curriculum frameworks are mapped to the data management plan requirements of the National Science Foundation and include lesson plans for seven instructional modules, a simplified data management plan, course readings, research cases in medicine, biomedical lab research, clinical behavioral health, and aerospace engineering. The Education Committee fully developed course content including readings, activities, research case excerpts, and assessment questions and answers for the fifth module, Legal and Ethical Considerations for Research Data, as proof of concept. Conclusions: Faculty and librarians have responded that the curriculum frameworks, when fully developed, will be a useful tool for providing data management instruction to undergraduate and graduate students enrolled in diverse science, health science and engineering courses. The modular format of the curriculum and variety of research cases is flexible ; allowing faculty to select modules that are relevant to their course programs. When completed, the curriculum can be delivered in multiple ways: face-to-face, as online interactive modules, or hybrid. Implementation funding for full development of the course modules, additional research cases, and piloting the curriculum modules is proposed

A Sample of Research Data Curation and Management Courses

Objective This paper identifies a sample of research data curation and management courses available at American Library Association-accredited Library and Information Science (LIS) Programs in North America. Methods This sample was identified through a content analysis of LIS program course descriptions and syllabi (N=58). Using a framework of research data management and curation competencies, the team gathered a sample of research data curation and management courses offered between fall 2011 and summer 2012. Results Only 13 (22%) of LIS programs currently offer a course focused on the management and curation of research data. Conclusion Although the literature supports LIS professionals adopting new roles and engaging in eScience and data management, most LIS data-related programs do not have a separate course solely focused on research data management. More LIS programs will need to adapt their curricula in order to help students and practicing professionals develop the needed competencies in research data curation and management

Teaching Research Data Management: An Undergraduate/Graduate Curriculum

Objective: With funding from the Institute of Museum and Library Services, the University of Massachusetts Medical School Library and Worcester Polytechnic Institute Library collaborated on a plan to expand the scope of science library practices and promote, among medical and graduate/undergraduate science students, the preservation of scientific data in relevant repositories/archives. This poster identifies user requirements and interface design elements for a system that can host student research data; outlines curriculum frameworks and learning needs for research data management instruction that can be delivered through a variety of methods; and presents a communication plan to inform others about the curriculum planning process and results. Methods: A steering committee and education board with representatives from each campus provided input into the new curriculum. Outside consultants also collected data from students at both schools via interviews, reviewed literature and course materials relevant to existing data management curricula, translated the findings into learning modules, and evaluated the planning process. Faculty with students doing research for capstone projects at both institutions will pilot the new curriculum in the spring of 2011. Student feedback will be recorded through pre- and post-testing and used to revise the curriculum prior to full scale implementation. Results: The curriculum focuses in nine areas: the data life cycle, data sharing requirements, naming conventions, metadata, storage, data ownership, security, privacy, and long-term access. Learning objectives were identified for each focus area and modified for the appropriate audience (undergraduate, graduate). Course content has been revised to be delivered in person over fifteen weeks in a classroom setting and also online in short self-paced modules. Conclusion: The need for research data management curricula was confirmed by students, literature review and external experts we spoke to. Collaboration pointed to a need for differing strategies as to how this curriculum and repository might be implemented successfully at the partner schools. Collaborative planning process can be strengthened via formative evaluation techniques

Single Cell Transcriptomics Reveal Abnormalities in Neurosensory Patterning of the Chd7 Mutant Mouse Ear

The chromatin remodeling protein CHD7 is critical for proper formation of the mammalian inner ear. Humans with heterozygous pathogenic variants in CHD7 exhibit CHARGE syndrome, characterized by hearing loss and inner ear dysplasia, including abnormalities of the semicircular canals and Mondini malformations. Chd7Gt/+ heterozygous null mutant mice also exhibit dysplastic semicircular canals and hearing loss. Prior studies have demonstrated that reduced Chd7 dosage in the ear disrupts expression of genes involved in morphogenesis and neurogenesis, yet the relationships between these changes in gene expression and otic patterning are not well understood. Here, we sought to define roles for CHD7 in global regulation of gene expression and patterning in the developing mouse ear. Using single-cell multiplex qRT-PCR, we analyzed expression of 192 genes in FAC sorted cells from Pax2Cre;mT/mGFP wild type and Chd7Gt/+ mutant microdissected mouse otocysts. We found that Chd7 haploinsufficient otocysts exhibit a relative enrichment of cells adopting a neuroblast (vs. otic) transcriptional identity compared with wild type. Additionally, we uncovered disruptions in pro-sensory and pro-neurogenic gene expression with Chd7 loss, including genes encoding proteins that function in Notch signaling. Our results suggest that Chd7 is required for early cell fate decisions in the developing ear that involve highly specific aspects of otic patterning and differentiation

The Academic Medical Library as Online Publisher

Objectives: To describe the use of an institutional repository system to facilitate the publishing activities of an academic medical library. Methods: The Library launched its institutional repository in 2006 and developed a mature collection of peer-reviewed articles, posters, and conference proceedings. Beginning in 2009, the Library sought to expand the use of the repository and partnered with two academic departments, Neurology and Psychiatry, to publish electronic journals. In spring 2011 the Library began to explore the idea of publishing its own peer-reviewed, open access electronic journal. Planning and implementation considerations included: choosing a unique and appropriate name; infrastructure and hosting options; organizational and governance structure; roles and responsibilities; journal structure and content; aims and scope; editorial, peer review and other policies and procedures; and dissemination. Simultaneously the Library undertook the publishing of its first electronic book, where issues of presentation, page turning, photo placement, and indexing became significant. Results: The inaugural issue of the Journal of eScience Librarianship was published on February 15, 2012 via the journal management platform of the Library’s institutional repository, eScholarship@UMMS. JESLIB has been assigned ISSN 2161-3974. The medical school joined CrossRef so that article metadata could be deposited into their system and each article assigned a DOI (Digital Object Identifier). Additional issues have been published, readership statistics and patterns are positive, and JESLIB is now indexed in the Directory of Open Access Journals. In fall 2012, the Library published its first eBook, “A History of the University of Massachusetts Medical School, which was authored by the medical school’s head of the Office of Medical History and Archives. Conclusions: Academic medical libraries can successfully publish as well as host online journals and books. Utilizing the institutional repository for publishing purposes offers a number of advantages. The repository provides a tested infrastructure for ingesting and sharing of documents. The repository administrator possesses strong in-house expertise, experience with embargoes, metadata, preservation and dissemination, and most importantly, has built strong relationships and trust with faculty and researchers. The open access platform leads to wider dissemination and maximum impact, backed up by reliable usage statistics. Helpful planning guides and other resources are available to assist libraries and academic groups in publishing open access peer-reviewed materials. Lessons learned include: utilize professional copy editing services; locking papers for revisions speeds up workflows

So You Want to Be a Publisher: Planning and Publishing the Journal of eScience Librarianship

Objective: To describe the planning process and activities of the University of Massachusetts Medical School\u27s Lamar Soutter Library around the publication of the new Journal of eScience Librarianship (JESLIB). Methods: The University of Massachusetts Medical School’s Lamar Soutter Library through funding from the National Network of Libraries of Medicine has been a leader in educating librarians about eScience and its impact on librarianship. In spring 2011 the Library began to explore the idea of publishing a peer-reviewed, open access electronic journal about eScience and data management for librarians. Planning and implementation considerations included: choosing a unique and appropriate name; infrastructure and hosting options; organizational and governance structure; roles and responsibilities; journal structure and content; aims and scope; editorial, peer review and other policies and procedures; and dissemination. Results: The inaugural issue of the Journal of eScience Librarianship (http://escholarship.umassmed.edu/jeslib/) was published on February 15, 2012 via the journal management platform of the Library\u27s institutional repository, eScholarship@UMMS. JESLIB has been assigned ISSN 2161-3974. The medical school joined CrossRef so that article metadata could be deposited into their system and each article assigned a DOI (Digital Object Identifier). Conclusion: Libraries can successfully publish as well as host online journals. Helpful planning guides and other resources are available to assist libraries and academic groups in publishing open access peer-reviewed journals. Lessons learned include: consider professional copy editing services to assist the Editorial Board; Editorial Team roles and responsibilities should be clearly defined but allow room for flexibility; and have a clear marketing communication and promotion strategy