1 research outputs found
Olive Component Oleuropein Promotes β‑Cell Insulin Secretion and Protects β‑Cells from Amylin Amyloid-Induced Cytotoxicity
Oleuropein, a natural
product derived from olive leaves, has reported
anti-diabetic functions. However, detailed molecular mechanisms for
how it affects β-cell functions remain poorly understood. Here,
we present evidence that oleuropein promotes glucose-stimulated insulin
secretion (GSIS) in β-cells. The effect is dose-dependent and
stimulates the ERK/MAPK signaling pathway. We further demonstrated
that oleuropein inhibits the cytotoxicity induced by amylin amyloids,
a hallmark feature of type 2 diabetes. We demonstrated that these
dual functions are structure-specific: we identified the 3-hydroxytyrosol
moiety of oleuropein as the main functional entity responsible for
amyloid inhibition, but the novel GSIS function requires the entire
structure scaffold of the molecule