Tests for population differences of <i>KLOTHO</i> methylation and important parameters.

<p>Tests for population differences of <i>KLOTHO</i> methylation and important parameters.</p

Flow chart of the meta-analysis.

<p>Flow chart of the meta-analysis.</p

Additional file 2: Figure S2. of Growth differentiation factor–15 predicts the prognoses of patients with acute coronary syndrome: a meta-analysis

Forest plots of GDF-15 with recurrent of MI. (TIF 25 kb

Sensitivity analysis for the APOA5 rs662799 polymorphism with CHD.

<p>Sensitivity analysis for the APOA5 rs662799 polymorphism with CHD.</p

Detailed information of the <i>APOA5</i> rs662799 cases included in the meta-analysis.

<p>Detailed information of the <i>APOA5</i> rs662799 cases included in the meta-analysis.</p

Characteristics of <i>KLOTHO</i> methylation and important parameters in the Xinjiang Uygur and Han Chinese.

<p>Characteristics of <i>KLOTHO</i> methylation and important parameters in the Xinjiang Uygur and Han Chinese.</p

Positive Association between <i>APOA5</i> rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis

<div><p>Objective</p><p>Apolipoprotein A5 (<i>APOA5</i>) is associated with plasma triglyceride (TG) levels, a risk factor for coronary heart disease (CHD). This study explored the association between CHD and the <i>APOA5</i> rs662799 polymorphism.</p><p>Methods</p><p>We collected 1,521 samples (783 CHD patients and 738 controls) for this case-control study. Meta-analysis was performed using Review Manager Software and Stata Software.</p><p>Results</p><p>Significant differences were observed between CHD cases and controls at the level of both genotype (χ² = 8.964, df = 2, P = 0.011) and allele (χ² = 9.180, df = 1, P = 0.002, OR = 1.275, 95% CI = 1.089–1.492). A breakdown analysis by gender showed a significant association of <i>APOA5</i> rs662799 with CHD in males (χ² = 7.770, df = 1, P = 0.005; OR = 1.331, 95% CI = 1.088–1.628). An additional meta-analysis using 21378 cases and 28428 controls established that rs662799 is significantly associated with CHD (P < 0.00001).</p><p>Conclusion</p><p>Both our case-control study and meta-analysis confirm a significant association between <i>APOA5</i> rs662799 and CHD. In addition, our results suggest a male-specific association between the <i>APOA5</i> rs662799 polymorphism and CHD.</p></div

Population difference of <i>KLOTHO</i> methylation.

<p>Population difference of <i>KLOTHO</i> methylation.</p

Forest plots of APOA5 rs662799 polymorphism with CHD risk in the Chinese, the Caucasian and the Asian populations*.

<p>*Events, the number of G alleles; total, total number of A and G alleles; our study: the CHD cases and controls in our study.</p

Tests for gender differences of <i>KLOTHO</i> methylation and important parameters.

<p>Tests for gender differences of <i>KLOTHO</i> methylation and important parameters.</p