Gold-Catalyzed Hydrosilyloxylation Driving Tandem Aldol and Mannich Reactions

The chemoselective formation of an enolate from alkyne in the presence of a carbonyl and imine group was realized, which constructed a variety of structural motifs under exceedingly mild reaction conditions in a tandem process. Reaction driving tandem hydrosilyloxylation/aldol reactions was achieved through the formation of enol silyl ethers catalytically generated in situ from readily available alkynes. These reactions were expanded to obtain β-amino enol silyl ethers in good yields <i>via</i> the tandem hydrosilyloxylation/isomerization/Mannich reaction

Synthesis of Naphthalenes via Platinum-Catalyzed Hydroarylation of Aryl Enynes

An efficient synthetic method of functionalized naphthalenes having hydrogen, alkyl, alkenyl, aryl, or heteroaryl groups on the 4-position and ethoxycarbonyl group on the 2-position was developed through selective Pt-catalyzed 6-<i>endo</i> intramolecular hydroarylation of ethyl (<i>E</i>)-2-ethynyl/alkynyl cinnamates

Synthesis of Substituted Coumarins via Brønsted Acid Mediated Condensation of Allenes with Substituted Phenols or Anisoles

Coumarins were obtained from the condensation of electron-rich arenes with allenes in the presence of TfOH in good yield. Depending on the substituent pattern of allenes employed, the general synthetic method of 4-substituted and 3,4-disubstituted 3-arylcoumarins has been developed. Readily available allenes were employed as the three-carbon atom sources constituting the coumarin skeleton