Datasheet1_The effect of non-optimal lipids on the progression of coronary artery calcification in statin-naïve young adults: results from KOICA registry.docx

BackgroundDespite the importance of attaining optimal lipid levels from a young age to secure long-term cardiovascular health, the detailed impact of non-optimal lipid levels in young adults on coronary artery calcification (CAC) is not fully explored. We sought to investigate the risk of CAC progression as per lipid profiles and to demonstrate lipid optimality in young adults.MethodsFrom the KOrea Initiative on Coronary Artery calcification (KOICA) registry that was established in six large volume healthcare centers in Korea, 2,940 statin-naïve participants aged 20–45 years who underwent serial coronary calcium scans for routine health check-ups between 2002 and 2017 were included. The study outcome was CAC progression, which was assessed by the square root method. The risk of CAC progression was analyzed according to the lipid optimality and each lipid parameter.ResultsIn this retrospective cohort (mean age, 41.3 years; men 82.4%), 477 participants (16.2%) had an optimal lipid profile, defined as triglycerides 60 mg/dl. During follow-up (median, 39.7 months), CAC progression was observed in 434 participants (14.8%), and more frequent in the non-optimal lipid group (16.5% vs. 5.7%; p ConclusionNon-optimal lipid levels were significantly associated with the risk of CAC progression in young adults, even at low-risk. Screening and intervention for non-optimal lipid levels, particularly triglycerides, from an early age might be of clinical value.</p

Characteristics of patients with VTE-related occult cancer.

<p>Characteristics of patients with VTE-related occult cancer.</p

Cox regression for the likelihood of occult or metastatic cancer according to D-dimer.

<p>Cox regression for the likelihood of occult or metastatic cancer according to D-dimer.</p

Flow chart of the study cohorts.

<p>Flow chart of the study cohorts.</p

Incidence proportion of occult cancer and cancer with metastatic state according to quantitative level of D-dimer.

<p>Incidence proportion of occult cancer and cancer with metastatic state according to quantitative level of D-dimer.</p

Incidence of occult cancer according to patient risk factors.

<p>Incidence of occult cancer according to patient risk factors.</p

Additional file 1: of Rationale and Design of the CREDENCE Trial: computed TomogRaphic evaluation of atherosclerotic DEtermiNants of myocardial IsChEmia

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