Controlling effect of tectonic-paleogeomorphology on deposition in the south of Lufeng sag, Pearl River Mouth Basin

Paleogene depositional systems in the south of Lufeng sag have complex spatial distribution, which are influenced by pre-depositional paleogeomorphology and multi-period tectonic activities. In this paper, to clarify the controlling effect of tectonic-paleogeomorphology on sedimentary facies distribution and effectively guide oil and gas exploration, the Paleogene paleogeomorphic pattern in the south of Lufeng sag is reconstructed by the impression method, and the temporal and spatial evolution laws of the main faults are clarified. The results show that braided river deltas developed stably in the long-axis gentle slope belt of the lake basin, while the short-axis sedimentary system changed from fan deltas to braided river deltas in response to the change of active strength of dominant faults from strong to weak. It is found that the scale of the sedimentary fan is closely related to the activity of the main fault, the area of the catchment, and the vertical elevation difference. The steep cliff is controlled by the boundary fault with large fault throw and steep section, and there are wedge-shaped sand bodies near the steep cliff. The multi-level fault-step zone provides the driving force for the advancement of the sedimentary system, and the sand body extends for a long distance. It is established that the supply capacity of the source area and the accommodated space of the lake basin are coupled to control the deposition scale. Moreover, the slope controlled by the combination of paleogeomorphic assemblage and the activity of the main fault determines the sedimentary type, and the structural slope-break zone defines the spreading pattern of the sands.Cited as: Jiang, M., Chen, D., Chang, X., Shu, L., Wang, F. Controlling effect of tectonic-paleogeomorphology on deposition in the south of Lufeng sag, Pearl River Mouth Basin. Advances in Geo-Energy Research, 2022, 6(5): 363-374. https://doi.org/10.46690/ager.2022.05.0

Vacuum brazing between SiCp/6063 Al MMCs and Fe-Ni alloys

This research paper deals with the joining of different materials such as SiCp/6063Al MMCs and Fe-Ni alloys by means of vacuum brazing with active filler metal Ag47-Cu18-In17-Sn17-Ti1. With the optimal process parameters, i.e., brazing temperature 580 °C, soaking time of 30 min and vacuum degree of 6.5×10-3 Pa, the joint shear strength can achieve the maximum of 56 MPa. Once the brazing temperature of 580 °C has exceeded the solidus temperature of SiCp/6063Al MMCs, the specimen can still keep the original shape due to the stiffness of composites. Sufficient diffusion between brazing filler metal and SiCp/6063Al MMCs could occur across the interface in liquid phase considerably faster than that in solid phase. The component analysis indicates that the elements in filler metal such as Ag, Sn and In can diffuse into SiCp/6063Al MMCs, which is believed to be beneficial for the joint quality

Criteria and favorable distribution area prediction of Paleogene effective sandstone reservoirs in the Lufeng Sag, Pearl River Mouth Basin

As the focus of conventional oil and gas exploration is changing from shallow to deep layers, the identification of deep effective reservoirs is crucial to exploration and development. In this paper, based on the geological anatomy of oil and gas reservoirs, a new discriminatory criterion and evaluation method for effective reservoirs is proposed in combination with the analysis of reservoir formation dynamics mechanism. The results show that the hydrocarbon properties of the reservoir vary with the ratio of the capillary force between the sandstone reservoir and its surrounding rock. The effective reservoir is discriminated and the reservoir quality is evaluated based on the capillary force and depth of the surrounding media and the sandstone reservoir for adjacent plates. When the capillary force ratio is greater than 0.6, fewer effective reservoirs are developed. The effective reservoir is determined by the capillary force ratio of the sandstone reservoir and the surrounding rock medium to mechanically explain the geological phenomenon that low-porosity reservoirs can also accumulate hydrocarbons. Our findings have significant guiding value for Paleogene oil and gas exploration in the Zhu I depression of Pearl River Mouth Basin.Cited as: Yu, S., Wang, C., Chen, D., Guo, B., Cai, Z., Xu, Z. Criteria and favorable distribution area prediction of Paleogene effective sandstone reservoirs in the Lufeng Sag, Pearl River Mouth Basin. Advances in Geo-Energy Research, 2022, 6(5): 388-401. https://doi.org/10.46690/ager.2022.05.0

チュウゴク ノ デンシ サンギョウ ノ ギジュツ ハッテン ト ニホン キギョウ ノ シンシュツ 1979ネン マツ カラ 2003ネン マデ

In this paper, technology transfer is discussed with regard to the electricity industry in China, referring to the case of transference from a certain Japanese home electric appliance company to the Chinese affiliates.First of all, I describe the historical background of the development of industrial technology in China. Secondly, governmental technology introduction policy in China is surveyed in the context of above mentioned historical background. Thirdly, I analyze concretely the technology transfer process from a certain Japanese home electric appliance company to the Chinese affiliates as a case study of technology transfer from Japan to China. Finally, I try to catch the implied meaning and lessons from the case study

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC

PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Phosphorylation of Microtubule- Associated Protein 4 Promotes Hypoxic Endothelial Cell Migration and Proliferation

Endothelial cells play a critical role in the process of angiogenesis during skin wound healing. The migration and proliferation of endothelial cells are processes that are initiated by the hypoxic microenvironment in a wound, but the underlying mechanisms remain largely unknown. Here, we identified a novel role for microtubule-associated protein 4 (MAP4) in angiogenesis. We firstly demonstrated that MAP4 phosphorylation was induced in hypoxic endothelial cells; the increase in MAP4 phosphorylation enhanced the migration and proliferation of endothelial cells. We also found that hypoxia (2% O2) activated p38/mitogen-activated protein kinase (MAPK) signaling, and we identified p38/MAPK as an upstream regulator of MAP4 phosphorylation in endothelial cells. Moreover, we showed that the promigration and proproliferation effects of MAP4 phosphorylation were attributed to its role in microtubule dynamics. These results indicated that MAP4 phosphorylation induced by p38/MAPK signaling promotes angiogenesis by inducing the proliferation and migration of endothelial cells cultured under hypoxic conditions via microtubule dynamics regulation. These findings provide new insights into the potential mechanisms underlying the initiation of the migration and proliferation of endothelial cells

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

<p>Abstract</p> <p>Background</p> <p>Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors. Many studies have shown that the NF-kappa B signaling pathway plays an important role in anti-apoptosis and the drug resistance of tumor cells during chemotherapy. In this study, the effects and mechanisms of GA and the NF-kappa B inhibitor celastrol on oral cancer cells were investigated.</p> <p>Methods</p> <p>Three human oral squamous cell carcinoma cell lines, Tca8113, TSCC and NT, were treated with GA alone, celastrol alone or GA plus celastrol. Cytotoxicity was assessed by MTT assay. The rate of apoptosis was examined with annexin V/PI staining as well as transmission electronic microscopy in Tca8113 cells. The level of constitutive NF-kappa B activity in oral squamous cell carcinoma cell lines was determined by immunofluorescence assays and nuclear extracts and electrophoretic mobility shift assays (EMSAs) <it>in vitro</it>. To further investigate the role of NF-kappa B activity in GA and celastrol treatment in oral squamous cell carcinoma, we used the dominant negative mutant SR-IκBα to inhibit NF-kappa B activity and to observe its influence on the effect of GA.</p> <p>Results</p> <p>The results showed that GA could inhibit the proliferation and induce the apoptosis of the oral squamous cell carcinoma cell lines and that the NF-kappa B pathway was simultaneously activated by GA treatment. The minimal cytotoxic dose of celastrol was able to effectively suppress the GA-induced NF-kappa B pathway activation. Following the combined treatment with GA and the minimal cytotoxic dose of celastrol or the dominant negative mutant SR-IκBα, proliferation was significantly inhibited, and the apoptotic rate of Tca8113 cells was significantly increased.</p> <p>Conclusion</p> <p>The combination of GA and celastrol has a synergistic antitumor effect. The effect can be primarily attributed to apoptosis induced by a decrease in NF-kappa B pathway activation. The NF-kappa B signaling pathway plays an important role in this process. Therefore, combining GA and celastrol may be a promising modality for treating oral squamous cell carcinoma.</p

Response of lymphocyte subsets and cytokines to Shenyang prescription in Sprague-Dawley rats with tongue squamous cell carcinomas induced by 4NQO

BACKGROUND: The study was designed to investigate immunocompetence in relation to cancer progression in rat and to assess the effect of the traditional Chinese anti-cancer medicine, "Shenyang" prescription, on immunity. METHODS: 4-Nitroquinoline-1-oxide (4NQO) was administered to 80 Sprague-Dawley (SD) rats via the drinking water for up to 36 weeks. Tongue squamous cell carcinoma (SCC) was confirmed by pathological examination in 61 rats. "Shenyang" prescription was administered to subgroups of these rats, and blood samples were taken before and after treatment. Lymphocyte subsets were determined by flow cytometry. Serum Th1 and Th2-type cytokines were assessed by an enzyme-linked immunosorbent assay. RESULTS: As the cancer progressed at the tongue root, the percentage of CD3+CD4+ T lymphocytes and NK cells and the levels of IFN-γ and IL-2 decreased gradually, while the percentage of CD3+CD8+ T lymphocytes and the levels of IL-4 and IL-10 increased. The CD4+/CD8+ ratios were lower in the cancer groups than in the control group. However, after administering "Shenyang" prescription, the levels of CD3+CD4+ T lymphocytes, NK cells, IFN-γ and IL-2 increased, while the CD3+CD8+ T lymphocyte counts and the levels of IL-4 and IL-10 decreased. CONCLUSION: 4NQO-induced lesions were good models for exploring oral cavity carcinogenesis. The rats with 4NQO-induced SCC demonstrated abnormalities in lymphocyte subsets and a shift from Th1-type to Th2-type, which were good models for assessing the effect of anticancer agent on immunity. Oral cancer progression was associated with an aggressive disturbance of immune function. "Shenyang" prescription has the ability to improve the disturbance of immune function