Forest plot of HNC risk associated with XRCC1 Arg399Gln gene polymorphism under all genetic models in total population.

<p>Forest plot of HNC risk associated with XRCC1 Arg399Gln gene polymorphism under all genetic models in total population.</p

Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under all genetic models in total population.

<p>Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under all genetic models in total population.</p

Forest plot of HNC risk associated with interaction between XRCC1 Arg194Trp polymorphism and smoking under a homozygote comparison.

<p>Forest plot of HNC risk associated with interaction between XRCC1 Arg194Trp polymorphism and smoking under a homozygote comparison.</p

Funnel plot for studies of the association of HNC risk and XRCC1 Arg399Gln gene polymorphism under an allelic genetic model.

<p>Funnel plot for studies of the association of HNC risk and XRCC1 Arg399Gln gene polymorphism under an allelic genetic model.</p

Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under a homozygote comparison in total population.

<p>Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under a homozygote comparison in total population.</p

DNA Repair Gene XRCC1 Polymorphisms and Head and Neck Cancer Risk: An Updated Meta-Analysis Including 16344 Subjects

<div><p>Background</p><p>DNA repair gene X-ray repair cross complementing group 1 (XRCC1) plays an important role in the maintenance of the genomic integrity and protection of cells from DNA damage. Sequence variation in XRCC1 gene may alter head and neck cancer (HNC) susceptibility. However, these results are inconclusive. To derive a more precise estimation of the relationship between XRCC1 polymorphism and HNC risk, we undertook a meta-analysis involving 16,344 subjects.</p> <p>Methods</p><p>A search of the literature by PubMed, Embase, Web of Science and China National Knowledge Infrastructure was performed to identify studies based on the predetermined inclusion criteria. The odds ratio (OR) with 95% confidence interval (CI) was combined using a random-effects model or a fixed-effects model.</p> <p>Results</p><p>Twenty-nine studies consisting of 6,719 cases and 9,627 controls were identified and analyzed. Overall, no evidence of significant association was observed between XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln genotypes and the risk of HNC in any genetic models. Subgroup analyses according to ethnicity, tumor site, publication year, genotyping method also detected no significant association in any subgroup, except that oral cancer was associated with Arg194Trp variant in recessive model. Furthermore, no significant effect of these polymorphisms interacted with smoking on HNC risk was detected but Arg194Trp homozygous variant.</p> <p>Conclusion</p><p>In conclusion, this meta-analysis suggests that the XRCC1 Arg194Trp, Arg280His and Arg399Gln polymorphism may not involve in HNC susceptibility. Further studies about gene-gene and gene-environment interactions in different populations are required.</p> </div

Flow diagram of articles selection process.

<p>Flow diagram of articles selection process.</p

Funnel plot for studies of the association of HNC risk and XRCC1 Arg194Trp gene polymorphism under an allelic genetic model.

<p>Funnel plot for studies of the association of HNC risk and XRCC1 Arg194Trp gene polymorphism under an allelic genetic model.</p

Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under a homozygote comparison on Asians.

<p>Forest plot of HNC risk associated with XRCC1 Arg194Trp gene polymorphism under a homozygote comparison on Asians.</p

Forest plot of HNC risk associated with XRCC1 Arg280His gene polymorphism under all genetic models in total population.

<p>Forest plot of HNC risk associated with XRCC1 Arg280His gene polymorphism under all genetic models in total population.</p