Extract of Allium tuberosum Rottler ex Spreng

Allium tuberosum Rottler ex Spreng (ATRES) has been used as a traditional medicine for the treatment of abdominal pain, diarrhea, and asthma. In this study, we investigated the hair growth promoting activities of ATRES on telogenic C57BL6/N mice. Hair growth was significantly increased in the dorsal skin of ethanol extract of ATRES treated mouse group compared with the control mouse group. To enrich the hair promoting activity, an ethanol-insoluble fraction was further extracted in sequence with n-hexane, dichloromethane, ethyl acetate, n-butanol, and distilled water. Interestingly, we found that extraction with n-butanol is most efficient in producing the hair promoting activity. In addition, the soluble fraction of the n-butanol extract was further separated by silica gel chromatography and thin layer chromatography (TLC) resulting in isolating four single fractions which have hair growth regeneration potential. Furthermore, administration of ATRES extracts to dorsal skin area increased the number of hair follicles compared with control mouse group. Interestingly, administration of ATRES extract stimulated the expression of insulin-like growth factor-1 (IGF-1) but not of keratin growth factor (KGF) or vascular endothelial growth factor (VEGF). Taken together, these results suggest that ATRES possesses strong hair growth promoting potential which controls the expression of IGF-1

Soft Tissue Surgery for Equinus Deformity in Spastic Hemiplegic Cerebral Palsy: Effects on Kinematic and Kinetic Parameters

The purpose of this study was to evaluate how soft tissue surgery for correcting equinus deformity affects the kinematic and kinetic parameters of the ankle and proximal joints. Sixteen children with spastic hemiplegic cerebral palsy and equinus deformities (age range 3-16 years) were included. Soft tissue surgeries were performed exclusively on the ankle joint area in all subjects. Using computerized gait analysis (Vicon 370 Motion Analysis System), the kinematic and kinetic parameters during barefoot ambulation were collected preoperatively and postoperatively. In all 16 children, the abnormally increased ankle plantar flexion and pelvis anterior tilting on the sagittal plane were significantly improved without a weakening of push-off (p < 0.05). In a group of 8 subjects with a recurvatum knee gait pattern before operation, the postoperative kinematic and kinetic parameters of the knee joint were significantly improved (p < 0.05). In a group of 8 subjects with ipsilateral pelvic external rotation before operation, the postoperative pelvic deviations on the transverse plane were significantly decreased (p < 0.05). These findings suggest that the soft tissue surgery for correcting equinus deformity improves not only the abnormal gait pattern of the ankle, but also that of the knee and pelvis

Generalizations of Choi's Orthogonal Latin Squares and Their Magic Squares

Choi Seok-Jeong studied Latin squares at least 60 years earlier than Euler. He introduced a pair of orthogonal Latin squares of order 9 in his book. Interestingly, his two orthogonal non-diagonal Latin squares produce a magic square of order 9, whose theoretical reason was not studied. There have been a few studies on Choi's Latin squares of order 9. The most recent one is Ko-Wei Lih's construction of Choi's Latin squares of order 9 based on two $3 \times 3$ orthogonal Latin squares. In this paper, we give a new generalization of Choi's orthogonal Latin squares of order 9 to orthogonal Latin squares of size $n^2$ using the Kronecker product including Lih's construction. We find a geometric description of Chois' orthogonal Latin squares of order 9 using the dihedral group $D_8$. We also give a new way to construct magic squares from two orthogonal non-diagonal Latin square, which explains why Choi's Latin squares produce a magic square of order 9.Comment: 18 pages revised slightly from Dec. 5, 2018 versio

Development of KAISTSAT-4 Expanding the Role of Small Satellite for Scientific Research

The fourth Korean small satellite, KAISTSAT-4, is under development by Satellite Technology Research Center (SaTReC) of the Korea Advanced Institute of Science and Technology (KAIST). The KAISTSAT-4 program was commenced on October 1998 with multiple mission objectives, which include exploring space science, deploying satellite-based data collection system and development of precision star sensor. Despite severe constraints on mass and size, these advanced science and engineering payloads are expected to deliver various useful results and exhibit the unique role of small satellite. We present an overview of the KAISTSAT-4 mission and describe its current status. Finally the prospect of future small satellite programs is briefly introduced

DeeLeMa: Missing information search with Deep Learning for Mass estimation

We present DeeLeMa, a deep learning network to analyze energies and momenta in particle collisions at high energy colliders, especially DeeLeMa is constructed based on symmetric event topology, and the generated mass distributions show robust peaks at the physical masses after the combinatoric uncertainties, and detector smearing effects are taken into account. DeeLeMa can be widely used in different event topologies by adopting the corresponding kinematic symmetries

Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection

Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs. First, we found that IL-7-mFc treatment augments the accumulation of pulmonary T cells in 2 ways: recruiting blood circulating T cells into the lung and expanding T cells at the lung parenchyma. Second, the blockade of T cell migration from the lymph nodes (LNs) with FTY720 treatment was not required for mounting the protective immunity to IAV with IL-7-mFc, suggesting a more important role of IL-7 in T cells in the lungs. Third, IL-7-mFc treatment also recruited various innate immune cells into the lungs. Among these cells, plasmacytoid dendritic cells (pDCs) play an important role in IL-7-mFc-mediated protective immunity through reducing the immunopathology and increasing IAV-specific cytotoxic T lymphocyte (CTL) responses. In summary, our results show that intranasal treatment with IL-7-mFc modulates pulmonary immune responses to IAV, affecting both innate and adaptive immune cells. ? 2017. The Korean Association of Immunologists.112Ysciescopuskc