Discussion on Rehabilitation Nursing of Patients with Post Injury in Clinical Emergency

In any case, preventing the injury of spinal before the application of the treatment for spinal injury has a positive significance. This can reduce or prevent the occurrence of the injury again. So, it reflects a very important significance treatment in the hospital. We use the pre-development and strictly followed the procedure of the spine injury and carry out the professional rescue procedure in the patients after the injury in order to obtain a very satisfactory result

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors, cytokines, and signaling molecules. A number of critical signaling molecules have been identified to regulate the differentiation of chondrocyte from mesenchymal progenitor cells to their terminal maturation of hypertrophic chondrocytes, including bone morphogenetic proteins (BMPs), SRY-related high-mobility group-box gene 9 (Sox9), parathyroid hormone-related peptide (PTHrP), Indian hedgehog (Ihh), fibroblast growth factor receptor 3 (FGFR3), and -catenin. Except for these molecules, other factors such as adenosine, O 2 tension, and reactive oxygen species (ROS) also have a vital role in cartilage formation and chondrocyte maturation. Here, we outlined the complex transcriptional network and the function of key factors in this network that determine and regulate the genetic program of chondrogenesis and chondrocyte differentiation

A Retrospective Analysis of the Clinical Features of Inpatients With Epilepsy in the Ganzi Tibetan Autonomous Prefecture

Background: There is limited detailed clinical information for patients with epilepsy in Tibet. This study sought to provide data about the clinical features of epilepsy in the Ganzi Tibetan Autonomous Prefecture to improve strategies for epilepsy prevention and management in this region.Methods: We reviewed the clinical record of patients with epilepsy in the Neurology Department, Ganzi Tibetan Autonomous Prefecture People's Hospital and compared the clinical features and compared it with control, from West China Hospital in Chengdu.Results: This retrospective study included 165 patients with epilepsy admitted between January 2015 and February 2018. Majority of patients (97%) in this study had active epilepsy; 28.5% had generalized onset seizures and 68.5% had focal onset seizures. Fifty-four patients had received anti-epileptic drug (AED) treatment prior to hospitalization, however, 38 (70.4%) patients took the medication irregularly. The leading etiology of this cohort was head trauma (20.6%), followed by stroke (10.9%), neurocysticercosis (7.9%), brain hydatidosis (6.7%) and tuberculous infection (5.5%). Compared with in-patients in Chengdu, epilepsy in Ganzi was more frequently caused by infection (OR = 4.216, 95% CI, 2.124–8.367), including neurocysticercosis (OR = 29.301, 95% CI, 1.727–497.167) and brain hydatidosis (OR = 24.637, 95% CI, 1.439–421.670).Conclusions: These data suggest that the control of cerebral infections, especially parasite infection, is essential for the prevention of epilepsy in the Ganzi Tibetan Autonomous Prefecture. Education of local primary doctors and patients about the literacy of epilepsy will enable better management of epilepsy in this population

The Signaling Pathways Involved in Chondrocyte Differentiation and Hypertrophic Differentiation

Chondrocytes communicate with each other mainly via diffusible signals rather than direct cell-to-cell contact. The chondrogenic differentiation of mesenchymal stem cells (MSCs) is well regulated by the interactions of varieties of growth factors, cytokines, and signaling molecules. A number of critical signaling molecules have been identified to regulate the differentiation of chondrocyte from mesenchymal progenitor cells to their terminal maturation of hypertrophic chondrocytes, including bone morphogenetic proteins (BMPs), SRY-related high-mobility group-box gene 9 (Sox9), parathyroid hormone-related peptide (PTHrP), Indian hedgehog (Ihh), fibroblast growth factor receptor 3 (FGFR3), and β-catenin. Except for these molecules, other factors such as adenosine, O2 tension, and reactive oxygen species (ROS) also have a vital role in cartilage formation and chondrocyte maturation. Here, we outlined the complex transcriptional network and the function of key factors in this network that determine and regulate the genetic program of chondrogenesis and chondrocyte differentiation

Genome-Wide Identification of the NHX Gene Family in Punica granatum L. and Their Expressional Patterns under Salt Stress

Most cultivated lands are suffering from soil salinization, which is a global problem affecting agricultural development and economy. High NaCl concentrations in the soil result in the accumulation of toxic Cl− and Na+ in plants. Na+/H+ antiporter (NHX) can regulate Na+ compartmentalization or efflux to reduce Na+ toxicity. This study aims to identify the NHX genes in pomegranate (Punica granatum L.) from the genome sequences and investigate their expression patterns under different concentrations of NaCl stress. In this study, we used the sequences of PgNHXs to analyze the physicochemical properties, phylogenetic evolution, conserved motifs, gene structures, cis-acting elements, protein tertiary structure and expression pattern. A total of 10 PgNHX genes were identified, and divided into three clades. Conserved motifs and gene structures showed that most of them had an amiloride-binding site (FFI/LY/FLLPPI), except for the members of clade III. There were multiple cis-acting elements involved in abiotic stress in PgNHX genes. Additionally, protein-protein interaction network analysis suggested that PgNHXs might play crucial roles in keeping a balance of Na+ in cells. The qRT-PCR analysis suggested that PgNHXs had tissue-specific expressional patterns under salt stress. Overall, our findings indicated that the PgNHXs could play significant roles in response to salt stress. The theoretical foundation was established in the present study for the further functional characterization of the NHX gene family in pomegranate

Research on a Novel Fabry–Perot Interferometer Model Based on the Ultra-Small Gradient-Index Fiber Probe

A novel Fabry–Perot (F–P) interferometer model based on the ultra-small gradient-index (GRIN) fiber probe is investigated. The signal arm of the F–P interferometer is organically combined with the ultra-small GRIN fiber probe to establish the theoretical model of the novel F–P interferometer. An interferometer experimental system for vibration measurements was built to measure the performance of the novel F–P interferometer system. The experimental results show that under the given conditions, the output voltage of the novel interferometer is 3.9 V at the working distance of 0.506 mm, which is significantly higher than the output voltage 0.48 V of the single-mode fiber (SMF) F–P interferometer at this position. In the range of 0.1–2 mm cavity length, the novel interferometer has a higher output voltage than an SMF F–P interferometer. Therefore, the novel F–P interferometer is available for further study of the precise measurement of micro vibrations and displacements in narrow spaces

The complete mitochondrial genome sequence of cultivated apple (Malus domestica cv. ‘Yantai Fuji 8’)

Apple is one of the most important fruit crops in international trade. In this study, we presented the complete mitochondrial genome sequence of apple cultivar ‘Yantai Fuji 8’. The complete mitochondrial genome is 396947 bp in length with an overall GC content of 45.40%. It contains 57 genes including 33 protein-coding genes, 4 rRNAs, and 20 tRNAs. The phylogenetic analysis showed that ‘Yantai Fuji 8’ was clustered with the Malus of Rosaceae family

Nitrogen Retention in Mesocosm Sediments Received Rural Wastewater Associated with Microbial Community Response to Plant Species

Vegetated drainage ditches (eco-ditches) have drawn much attention in recent years for the ability to remediate diffuse contaminants in rural wastewater through sediment retention, plant uptake and interception, and microbial metabolic activities. However, the effect of plant species on microbial community structure and nitrogen (N) retention in ditch sediment remains poorly understood. In this study, mesocosm plastic drums were planted with eight plant species commonly found in ditches and nurtured with wastewater for 150 days. Sediment total nitrogen (TN) was greatly increased after 150-day nurturing with rural wastewater, from 296.03 mg∙kg−1 (Iris japonica Thunb) to 607.88 mg∙kg−1 (Acorus gramineusO). This study also presents the effect of different plant species on sediment microbial communities, thus providing insight into N removal mechanisms in eco-ditch. Fifty-eight differentially abundant taxa were identified, and sediment microbial community structure for no plant (CK), Acg, Canna indica (Cai), and Typha latifolia L. (Tyl) was primarily linked to sediment NH4+-N and TN. Extremely small proportions of ammonia oxidizing bacteria (AOB) and nitrifying bacteria were detected for all treatments, but large proportions of Crenarchaeota, which comprises the widely existent ammonium oxidized archaea (AOA), were found in CK, Acg and Cai. The abundance of Nitrosotalea from Crenarchaeota presented positive correlations with sediment NH4+-N contents and ammonia oxidation function predicted by Faprotax, indicating Nitrosotalea might be the dominant ammonium-oxidizing microbes in sediment samples. The probable NH4+-N removal pathway in wastewater sediment was through a combined effect of AOA, nitrifying bacteria, and anammox

Arabidopsis sucrose transporter 4 (AtSUC4) is involved in high sucrose-mediated inhibition of root elongation

AbstractSucrose transporters (SUCs/SUTs) play crucial roles in apoplast transport and long-distance distribution of sucrose throughout the whole plant. However, whether and how the Arabidopsis AtSUC4 modulates sucrose import from apoplast to cytosol remains unclear. In the present study, we found that AtSUC4 protein was localized to the plasma membrane in the root. Expression of AtSUC4 in roots was gradually induced with the increasing sucrose concentrations (0%, 2%, 4% and 6%). When feeding high concentrations (4% and 6%) of sucrose, the primary root growth of seedling was inhibited. Interestingly, atsuc4 mutants exhibited longer primary root than the wild type under these conditions, indicating that atsuc4 mutants were less sensitive to excess sucrose. Moreover, the root of atsuc4 mutants accumulated less sucrose and abscisic acid (ABA) and more indole-3-acetic acid (IAA) on 4% and 6% sucrose supplementation. Transcriptomic analysis revealed that numerous genes associated with sugar transport and metabolism, as well as ABA signalling were down-regulated, whereas many IAA signaling-related genes were up-regulated in mutant plants relative to the wild type under 6% sucrose treatment. Collectively, our finding demonstrated that the deficiency of AtSUC4 reduced the inhibition of primary root growth under high sucrose condition, probably through reducing the sucrose transportation and metabolism, and subsequent alteration in IAA and ABA signalling