Antioxidant Supplementation in the Treatment of Aging-Associated Diseases

Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level. Elderly people are more susceptible to oxidative stress and this depends, almost in part, from a decreased performance of their endogenous antioxidant system. As many studies reported an inverse correlation between systemic levels of antioxidants and several diseases, primarily cardiovascular diseases, but also diabetes and neurological disorders, antioxidant supplementation has been foreseen as an effective preventive and therapeutic intervention for aging-associated pathologies. However, the expectations of this therapeutic approach have often been partially disappointed by clinical trials. The interplay of both endogenous and exogenous antioxidants with the systemic redox system is very complex and represents an issue that is still under debate. In this review a selection of recent clinical studies concerning antioxidants supplementation and the evaluation of their influence in aging-related diseases is analyzed. The controversial outcomes of antioxidants supplementation therapies, which might partially depend from an underestimation of the patient specific metabolic demand and genetic background, are presented

Chiral Lagrangians with tensor sources

The implementation of tensor sources in Chiral Lagrangians allows the computation of Green functions and form factors involving tensor currents, that is, quark bilinears of the form \bar{q}_i\sigma^{\mu\nu}q_j. Whereas only four new terms show up at O(p^4), we find around a hundred of them at O(p^6). So it becomes essential to ensure that this set o operators is indeed minimal and non-redundant (i.e., it is a basis). We discuss two phenomenological applications in the context of vector meson resonances and the radiative pion decay.Comment: Talk given at the 4th International Worshop on Quantum ChromoDynamics, Theory and experiment, June 16-20, 2007. Martina Franca - Valle d'Itria - Ital

Test particle motion in a gravitational plane wave collision background

Test particle geodesic motion is analysed in detail for the background spacetimes of the degenerate Ferrari-Ibanez colliding gravitational wave solutions. Killing vectors have been used to reduce the equations of motion to a first order system of differential equations which have been integrated numerically. The associated constants of the motion have also been used to match the geodesics as they cross over the boundary between the single plane wave and interaction zones.Comment: 11 pages, 6 Postscript figure

Neutrino current in a gravitational plane wave collision background

The behaviour of a massless Dirac field on a general spacetime background representing two colliding gravitational plane waves is discussed in the Newman-Penrose formalism. The geometrical properties of the neutrino current are analysed and explicit results are given for the special Ferrari-Ibanez solution.Comment: 17 pages, 6 Postscript figures, accepted by International Journal of Modern Physics

Analytical results for long time behavior in anomalous diffusion

We investigate through a Generalized Langevin formalism the phenomenon of anomalous diffusion for asymptotic times, and we generalized the concept of the diffusion exponent. A method is proposed to obtain the diffusion coefficient analytically through the introduction of a time scaling factor $\lambda$. We obtain as well an exact expression for $\lambda$ for all kinds of diffusion. Moreover, we show that $\lambda$ is a universal parameter determined by the diffusion exponent. The results are then compared with numerical calculations and very good agreement is observed. The method is general and may be applied to many types of stochastic problem

A novel stepwise micro-TESE approach in non obstructive azoospermia

Background: The purpose of the study was to investigate whether micro-TESE can improve sperm retrieval rate (SRR) compared to conventional single TESE biopsy on the same testicle or to contralateral multiple TESE, by employing a novel stepwise micro-TESE approach in a population of poor prognosis patients with non-obstructive azoospermia (NOA). Methods: Sixty-four poor prognosis NOA men undergoing surgical testicular sperm retrieval for ICSI, from March 2007 to April 2013, were included in this study. Patients inclusion criteria were a) previous unsuccessful TESE, b) unfavorable histology (SCOS, MA, sclerahyalinosis), c) Klinefelter syndrome. We employed a stepwise micro-TESE consisting three-steps: 1) single conventional TESE biopsy; 2) micro-TESE on the same testis; 3) contralateral multiple TESE. Results: SRR was 28.1 % (18/64). Sperm was obtained in both the initial single conventional TESE and in the following micro-TESE. The positive or negative sperm retrieval was further confirmed by a contralateral multiple TESE, when performed. No significant pre-operative predictors of sperm retrieval, including patients’ age, previous negative TESE or serological markers (LH, FSH, inhibin B), were observed at univariate or multivariate analysis. Micro-TESE (step 2) did not improve sperm retrieval as compared to single TESE biopsy on the same testicle (step 1) or multiple contralateral TESE (step 3). Conclusions: Stepwise micro-TESE could represent an optimal approach for sperm retrieval in NOA men. In our view, it should be offered to NOA patients in order to gradually increase surgical invasiveness, when necessary. Stepwise micro-TESE might also reduce the costs, time and efforts involved in surgery

Dynamics and Hadronization at intermediate transverse momentum at RHIC

The ultra-relativistic heavy-ion program at RHIC has shown that at intermediate transverse momenta ($p_T \simeq 2$-6 GeV) standard (independent) parton fragmentation can neither describe the observed baryon-to-meson ratios nor the empirical scaling of the hadronic elliptic flow ($v_2$) according to the number of valence quarks. Both aspects find instead a natural explanation in a coalescence plus fragmentation approach to hadronization. After a brief review of the main results for light quarks, we focus on heavy quarks showing that a combined fragmentation and quark-coalescence framework is relevant also here. Moreover, within relativistic Langevin simulations we find evidence for the importance of heavy-light resonances in the Quark-Gluon Plasma (QGP) to explain the strong energy loss and collective flow of heavy-quark spectra as inferred from non-photonic electron observables. Such heavy-light resonances can pave the way to a unified understanding of the microscopic structure of the QGP and its subsequent hadronization by coalescence.Comment: Proceedings of the International Workshop on QCD - Martina Franca (Italy), June 2007. To be published in AIP. 6 pages, 6 figure