7 research outputs found
Rapid testing for respiratory syncytial virus in a resource-limited paediatric intensive care setting
Newman H, Tshabalala D, Mabunda S, et al. Rapid testing for respiratory syncytial virus in a resource-limited paediatric intensive care setting. Afr J Lab Med. 2020;9(1)We analysed the performance characteristics of the respiratory syncytial virus lateral flow rapid antigen assay in use when compared to a multiplex polymerase chain reaction for detection of respiratory viruses. The study was conducted at a tertiary paediatric hospital in Port Elizabeth, South Africa, from 01 January 2017 to 31 December 2018. We found the clinical sensitivity (36.8%) of the rapid test to be too low for routine diagnostic use. Knowledge of assay performance characteristics of rapid tests are important for appropriate interpretation of rapid test results
Hepatitis A in Nelson Mandela Bay and Sarah Baartman districts, Eastern Cape, South Africa
CITATION: Newman, H., et al. 2018. Hepatitis A in Nelson Mandela Bay and Sarah Baartman districts, Eastern Cape, South Africa. Southern African Journal of Infectious Diseases, 33(5):1-4, doi:10.4102/sajid.v33i5.148.The original publication is available at https://sajid.co.zaBackground: Hepatitis A is the most common cause of acute viral hepatitis, not only in South Africa, but in many other countries.
In South Africa, there is a lack of data regarding the true incidence of hepatitis A, and even fewer data regarding hepatitis A cases
requiring hospitalisation. In the Eastern Cape province of South Africa in particular, there is a paucity of published data that could
be used to guide public health officials. An analysis of all the laboratory-confirmed cases in the area over a period of time may
help to better describe the extent of the problem.
Methods: This was a retrospective study analysing the laboratory-confirmed cases of hepatitis A in the Nelson Mandela Bay and
Sarah Baartman districts of the Eastern Cape province in South Africa for the three-year period from 2015 to 2017.
Results: A total of 194 laboratory-confirmed cases of hepatitis A were identified for the three-year period from 2015 to 2017. Of
these, 138 (71%) cases were children 16 years old or younger, with adults accounting for 56 cases (29%). There was no overall
seasonality associated with laboratory-confirmed cases of hepatitis A.
Conclusions: Hepatitis A is a serious problem in the Eastern Cape region. More studies are needed to determine the exact cause
of the continuing epidemic.https://sajid.co.za/index.php/sajid/article/view/148Publisher's versio
Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape
CITATION: Tshabalala, D., et al. 2018. Prevalence and determinants of congenital cytomegalovirus infection at a rural South African central hospital in the Eastern Cape. Southern African Journal of Infectious Diseases, 33(4):89-92, doi:10.1080/23120053.2018.1462560.The original publication is available at https://sajid.co.zaBackground: The Nelson Mandela Academic Hospital (NMAH) in Mthatha, Eastern Cape, is a rural central hospital, serving one of
the poorest districts in South Africa. The prevalence of and risk factors for congenital cytomegalovirus (CMV) in this area are not
known. The aim was to evaluate the prevalence of congenital CMV and associated risk factors for babies born at NMAH.
Methods: This was a cross-sectional study to determine the prevalence of congenital CMV infection among babies born at
Nelson Mandela Academic Hospital. Mother–baby pairs delivered consecutively from Monday to Friday, who gave informed
consent, were included. Demographic information was collected on a questionnaire. All babies were tested for congenital CMV
using a saliva swab PCR within the first week of life.
Results: A total of 302 births were assessed. Congenital CMV was prevalent in 18 births (5.96%; 95% CI 3.29–8.63) and had an
equal prevalence between HIV-exposed and HIV-unexposed newborns (prevalence ratio [PR] = 1.00; 95% CI 0.94–1.06; p = 0.869).
Conclusions: The prevalence of congenital CMV of 5.96% is similar to findings from other resource-limited settings. There was no
significant association between maternal HIV status and congenital CMV. With the prevalence of congenital CMV being as high as
it is in the studied setting, clinicians are advised to have a high index of suspicion, especially when mothers are CMV seropositive.https://sajid.co.za/index.php/sajid/article/view/155Publisher's versio