The double crisis: in what sense a regional problem?

We are now facing Sayer’s ‘diabolical double crisis’– which encompasses both a deep financial crisis and an environmental one. The scale, scope and nature of this double-crisis is downplayed in the regional studies literature, much of which still focuses on innovative growth models often divorced from broader social and ecological contexts. To help solve both crises we call for regional studies to explore new models that allow us to focus on the most important issues of our time. We illustrate this by focusing on the contradictions in the waste produced by contemporary regional economies – waste of abundance, labour, and resources.Cambridge Political Economy Trust/Centre for Business Research, University of Cambridge, 2015-2018 British Academy/Leverhulme Small Research Grant – SRG 201

Toward a Next Generation Data Modeling Facility: Neither the Entity-Relationship Model nor UML Meet the Need

In this article, we define five purposes of a data model and describe a typical data modeling problem. We then evaluate the Entity-Relationship and Unified Modeling Language data models against those five purposes in the context of the example problem. We find severe limitations with both data models. We conclude the article with a survey of the characteristics needed for a new data model

Assessing austerity

This is the introduction to the Virtual Special Issue on Austerity, drawing articles from the three journals owned and managed by the Cambridge Political Economy Society: Cambridge Journal of Economics, the Cambridge Journal of Regions, Economy and Society and Contributions to Political Economy. http://oxfordjournals.org/our_journals/cameco/asessing-austerity.htm

How effective are MPAs in conserving crab stocks? A comparison of fisheries and conservation objectives in three coastal MPAs in Thailand

Mangrove forest ecosystems support aquatic species important to tropical fishing communities, but habitat degradation and over-fishing have caused coastal fishery stocks to decline. Marine Protected Areas (MPAs) are widely promoted as a management option to reverse this situation. Using swimming crabs as indicator species, this paper explores the ecological effectiveness of two community-led MPAs and one co-managed MPA in Ranong and Phang-nga Provinces in southern Thailand. Comparisons were made of two fisheries objectives: catch per unit effort (CPUE); and size frequency distribution of Portunus spp. and Scylla olivacea; and one conservation objective: catch composition on benthic aquatic species, between each managed area and an associated control site to look for effects of management. Eight replicates of each survey were undertaken in each site: four in the wet season, from May to July 2011; and four in the dry season, from February to March 2012. Two of the MPAs, one a no-take zone and one a gear limitation zone, and both managed by local communities, showed a significant increase in CPUE of target species compared with their controls to the benefit of local fishers. There was little evidence of management impact on the composition of benthic aquatic species so community management is not achieving wider conservation in terms of increased biodiversity. The third MPA, a seasonal no-take zone, co-managed by local communities and local government, showed no significant effect on either CPUE of target species, or composition of benthic aquatic species when compared to its control. For size frequency distribution, a higher abundance of all size classes of Portunus pelagicus was observed in all MPAs compared to their control sites. The size distribution of animals suggests that the community-managed MPAs are supporting recruits and contributing to the fisheries by reducing the rates of growth overfishing. To conclude, the two community-led MPAs benefitted fishers but had no effect on marine biodiversity, while the co-managed MPA did not benefit fishers or marine biodiversity. However, all three MPAs showed increase crab abundance in each size class

The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent

Aims: The data regarding the associations of body mass index (BMI) with cardiovascular (CVD) risk, especially for those at the low categories of BMI, are conflicting. The aim of our study was to examine the associations of body composition (assessed by five different measures) with incident CVD outcomes in healthy individuals. Methods and results: A total of 296 535 participants (57.8% women) of white European descent without CVD at baseline from the UK biobank were included. Exposures were five different measures of adiposity. Fatal and non-fatal CVD events were the primary outcome. Low BMI (≤18.5 kg m−2) was associated with higher incidence of CVD and the lowest CVD risk was exhibited at BMI of 22–23 kg m−2 beyond, which the risk of CVD increased. This J-shaped association attenuated substantially in subgroup analyses, when we excluded participants with comorbidities. In contrast, the associations for the remaining adiposity measures were more linear; 1 SD increase in waist circumference was associated with a hazard ratio of 1.16 [95% confidence interval (CI) 1.13–1.19] for women and 1.10 (95% CI 1.08–1.13) for men with similar magnitude of associations for 1 SD increase in waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass. Conclusion: Increasing adiposity has a detrimental association with CVD health in middle-aged men and women. The association of BMI with CVD appears more susceptible to confounding due to pre-existing comorbidities when compared with other adiposity measures. Any public misconception of a potential ‘protective’ effect of fat on CVD risk should be challenged

Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants

Background: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study. Methods: This study included cross-sectional data from 48 170 white European adults, aged 37–73 years, participating on the UK Biobank. Interactions between GPRS-obesity, and macronutrient intake (including total energy, protein, fat, carbohydrate and dietary fibre intake) and its effects on BMI and WC were investigated. Results: The 93-SNPs genetic profile risk score was associated with a higher BMI (β:0.57 kg.m−2 per standard deviation (s.d.) increase in GPRS, [95%CI:0.53–0.60]; P=1.9 × 10−183) independent of major confounding factors. There was a significant interaction between GPRS and total fat intake (P[interaction]=0.007). Among high fat intake individuals, BMI was higher by 0.60 [0.52, 0.67] kg.m−2 per s.d. increase in GPRS-obesity; the change in BMI with GPRS was lower among low fat intake individuals (β:0.50 [0.44, 0.57] kg.m-2). Significant interactions with similar patterns were observed for saturated fat intake (High β:0.66 [0.59, 0.73] versus Low β:0.49 [0.42, 0.55] kg.m-2, P-interaction=2 × 10-4), and total energy intake (High β:0.58 [0.51, 0.64] versus Low β:0.49 [0.42, 0.56] kg.m−2, P-interaction=0.019), but not for protein intake, carbohydrate intake and fiber intake (P-interaction >0.05). The findings were broadly similar using WC as the outcome. Conclusions: These data suggest that the benefits of reducing the intake of fats and total energy intake, may be more important in individuals with high genetic risk for obesity

Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study

OBJECTIVE Grip strength and diabetes are predictors of mortality and cardiovascular disease (CVD), but whether these risk factors interact to predispose to adverse health outcomes is unknown. This study determined the interactions between diabetes and grip strength and their association with health outcomes. RESEARCH DESIGN AND METHODS We undertook a prospective, general population cohort study by using UK Biobank. Cox proportional hazards models were used to explore the associations between both grip strength and diabetes and the outcomes of all-cause mortality and CVD incidence/mortality as well as to test for interactions between diabetes and grip strength. RESULTS 347,130 UK Biobank participants with full data available (mean age 55.9 years, BMI 27.2 kg/m2, 54.2% women) were included in the analysis, of which 13,373 (4.0%) had diabetes. Over a median follow-up of 4.9 years (range 3.3–7.8 years), 6,209 died (594 as a result of CVD), and 4,301 developed CVD. Participants with diabetes were at higher risk of all-cause and CVD mortality and CVD incidence. Significant interactions (P < 0.05) existed whereby the risk of CVD mortality was higher in participants with diabetes with low (hazard ratio [HR] 4.05 [95% CI 2.72, 5.80]) versus high (HR 1.46 [0.87, 2.46]) grip strength. Similar results were observed for all-cause mortality and CVD incidence. CONCLUSIONS Risk of adverse health outcomes among people with diabetes is lower in those with high grip strength. Low grip strength may be useful to identify a higher-risk subgroup of patients with diabetes. Intervention studies are required to determine whether resistance exercise can reduce risk

Sharing economies: Moving beyond binaries in a digital age

In periods of turbulence, the tendency to simplify messages and polarise debates is nothing new. In our hyper-mediated world of online technologies, where it seems that even national policy can be forged in the 140 characters of Twitter, it is more important than ever to retain spaces for in-depth debate of emergent phenomena that have disruptive and transformative potential. In this article, we follow this logic and argue that to fully understand the diverse range of practices and potential consequences of activities uncomfortably corralled under the ambiguous term 'the sharing economy' requires not a simplification of arguments, but an opening out of horizons to explore the many ways in which these phenomena have emerged and are evolving. It is argued that this will require attention to multiple terrains, from diverse intellectual traditions across many disciplines to the thus far largely reactive responses of government and regulation, and from the world of techno-innovation start-ups to the optics of media (including social media) reporting on what it means to 'share' in the 21st century. Building on this, we make the case for viewing 'the sharing economy' as a matrix of diverse economies with clear links to past practices. We propose that to build a grammar for understanding these diverse sharing economies requires further attention to: (1) The etymology of sharing and sharing economies; (2) The differentiated geographies to which sharing economies contribute; (3) What it means to labour, work and be employed in sharing economies; (4) The role of the state and others in governing, regulating and shaping the organisation and practice of sharing economies; and (5) the impacts of sharing economies. In conclusion, we suggest that while media interest may fade as their presence in everyday lives becomes less novel, understanding sharing economies remains an urgent activity if we are to ensure that the new ways of living and labouring, to which sharing economies are contributing, work to promote sustainable and inclusive development in this world that ultimately we all share

Associations of grip strength with cardiovascular, respiratory, and cancer outcomes and all cause mortality: prospective cohort study of half a million UK Biobank participants

Objective: To investigate the association of grip strength with disease specific incidence and mortality and whether grip strength enhances the prediction ability of an established office based risk score. Design: Prospective population based study. Setting: UK Biobank. Participants: 502 293 participants (54% women) aged 40-69 years. Main outcome measures: All cause mortality as well as incidence of and mortality from cardiovascular disease, respiratory disease, chronic obstructive pulmonary disease, and cancer (all cancer, colorectal, lung, breast, and prostate). Results: Of the participants included in analyses, 13 322 (2.7%) died over a mean of 7.1 (range 5.3-9.9) years’ follow-up. In women and men, respectively, hazard ratios per 5 kg lower grip strength were higher (all at P<0.05) for all cause mortality (1.20, 95% confidence interval 1.17 to 1.23, and 1.16, 1.15 to 1.17) and cause specific mortality from cardiovascular disease (1.19, 1.13 to 1.25, and 1.22, 1.18 to 1.26), all respiratory disease (1.31, 1.22 to 1.40, and 1.24, 1.20 to 1.28), chronic obstructive pulmonary disease (1.24, 1.05 to 1.47, and 1.19, 1.09 to 1.30), all cancer (1.17, 1.13 to 1.21, 1.10, 1.07 to 1.13), colorectal cancer (1.17, 1.04 to 1.32, and 1.18, 1.09 to 1.27), lung cancer (1.17, 1.07 to 1.27, and 1.08, 1.03 to 1.13), and breast cancer (1.24, 1.10 to 1.39) but not prostate cancer (1.05, 0.96 to 1.15). Several of these relations had higher hazard ratios in the younger age group. Muscle weakness (defined as grip strength <26 kg for men and <16 kg for women) was associated with a higher hazard for all health outcomes, except colon cancer in women and prostate cancer and lung cancer in both men and women. The addition of handgrip strength improved the prediction ability, based on C index change, of an office based risk score (age, sex, diabetes diagnosed, body mass index, systolic blood pressure, and smoking) for all cause (0.013) and cardiovascular mortality (0.012) and incidence of cardiovascular disease (0.009). Conclusion: Higher grip strength was associated with a range of health outcomes and improved prediction of an office based risk score. Further work on the use of grip strength in risk scores or risk screening is needed to establish its potential clinical utility

Impact of anthropogenic and natural environmental changes on Echinococcus transmission in Ningxia Hui Autonomous Region, the People’s Republic of China

Echinococcus transmission is known to be affected by various environmental factors, which may be modified by human influence or natural events including global warming. Considerable population growth in the last fifty years in Ningxia Hui Autonomous Region (NHAR), the People's Republic of China (PRC), has led to dramatic increases in deforestation and modified agricultural practices. In turn, this has resulted in many changes in the habitats for the definitive and intermediate hosts of both Echinococcus granulosus and E. multilocularis, which have increased the risks for transmission of both parasites, affecting echinococcosis prevalence and human disease. Ecological environmental changes due to anthropogenic activities and natural events drive Echinococcus transmission and NHAR provides a notable example illustrating how human activity can impact on a parasitic infection of major public health significance. It is very important to continually monitor these environmental (including climatic) factors that drive the distribution of Echinococcus spp. and their impact on transmission to humans because such information is necessary to formulate reliable future public health policy for echinococcosis control programs and to prevent disease spread.We acknowledge financial support by the National Health and Medical Research Council (NHMRC) of Australia (APP1009539) and the Natural Science Foundation of China (NSFC) (30960339) for our studies on echinococcosis. DJG is an Australian Research Council Fellow (DECRA); DPM is a NHMRC Senior Principal Research Fellow; ACAC is a NHMRC Career Development Fellow