A network representation of the CORUM database.

<p>Nodes represent complexes and are ordered by number of unique components (shown as number next to groups). Edges denote shared components between complexes. The number of shared components is reflected in the colour (from yellow (few) to red (many) shared components) as well as in the line width. The large, highly overlapping complexes in the first row are mainly modules of the ribosome (6 out of 12) and spliceosome (3 out of 12). Other large complexes include RNA polymerase, respiratory chain complex and the proteasome. The group of complexes with only 1 member are homo-dimers.</p

Composition of the CORUM database.

<p>Underrepresented terms are set in bold font.</p

Distribution of average Pearson correlation coefficients between all members of known proteins complexes as defined in CORUM (black), and randomly sampled proteins (white, N = 10).

<p>Expression data was taken from the Human Gene Expression Atlas (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0009474#s2" target="_blank">Methods</a>).</p

Difference between deletion (white) and duplication (black) variations in HapMap individuals.

<p>The histograms show the ratio of average expression levels between individuals with and without the CNV for all genes inside a CNV region. The shift between the two distributions is significantly larger than would be expected by chance (MWU: ).</p