Going public : authentic teaching and learning through publication

As the burdens of high-stakes testing and teacher evaluation systems move toward more quantitative measures, it is even more pressing to preserve the sanctity of creative teaching and learning endeavors. It is with this in mind that the author strives to present a collaborative, project-based learning experience that is at once authentic and aligned to nationally recognized standards for excellence in teaching and learning

Fact Through Fiction: A Case Study of Televised Historical Drama's Influence on Audiences' Perceptions of the Past

Thesis advisor: William StanwoodThesis advisor: Lindsay HoganNever before has it been so important to investigate the way in which televised historical drama recreates and represents the past, for, as Robert Rosenstone (2003) acknowledges, “the increasing presence of the visual media in modern culture and the vast increase in TV channels seems to ensure that most people now get their knowledge of the past, once school is over, from the visual media” (p. 10). Therefore, this research uses the popular PBS Masterpiece Theatre program Downton Abbey as a case study to examine the accuracy of depictions of historical periods in contemporary television programs with the intent of discovering the impact of historical fiction on audiences’ perceptions of the past and, subsequently, on the collective memory of the public domain. Using a reception analysis approach, this research considers both producer-encoded and audience-decoded content within the four categories of (I) Setting, Details, and Design; (II) History; (III) Behavior; and (IV) Agenda, Values, and Effects outlined by Paul B. Weinstein (2001) to form conclusions concerning the relationship between the encoding and decoding of Downton Abbey, in particular, as well as the larger implications these findings have for televised historical drama and society’s collective memory, in general. Ultimately, this essay argues that through its precision of post-Edwardian detail, Downton Abbey attempts to construct a veil of accuracy behind which the series’ narrative is theoretically able to operate freely and without rigid constraint by history’s “hard and fast rules” (Fellowes, 2012a, p. 60). The findings also reveal an incongruity between this philosophy of encoding and the subsequent decoding process of Downton Abbey’s audience members. Finally, this study offers two potential functions historical drama may serve in contemporary society: as either a catalyst for historical inquiry or as a purveyor of distinctly modern, as opposed to historical, lessons.Thesis (BA) — Boston College, 2014.Submitted to: Boston College. College of Arts and Sciences.Discipline: College Honors Program.Discipline: Communication Honors Program.Discipline: Communication

A Common Place, Volume 2, Spring 2023

Editor in Chief: Emily Steffenhagen Editorial Assistant: Chloe Johnson Prose Editor: Jake Robinson Poetry Editor: Kyla Brown Art Editor: Elliott Jimerson Web Editor: Elle Degaetano Design: Kate Frey Readers: Dalton Whitby, Kylie Wheeler, Sierra Sweezy, Myeisha Hamiltonhttps://digitalcommons.longwood.edu/special_studentpubs/1217/thumbnail.jp

Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters

Clostridium difficile is the leading cause of nosocomial antibiotic-associated diarrhea, and recent outbreaks of strains with increased virulence underscore the importance of identifying novel approaches to treat and prevent relapse of Clostridium difficile-associated diarrhea (CDAD). CDAD pathology is induced by two exotoxins, toxin A and toxin B, which have been shown to be cytotoxic and, in the case of toxin A, enterotoxic. In this report we describe fully human monoclonal antibodies (HuMAbs) that neutralize these toxins and prevent disease in hamsters. Transgenic mice carrying human immunoglobulin genes were used to isolate HuMAbs that neutralize the cytotoxic effects of either toxin A or toxin B in cell-based in vitro neutralization assays. Three anti-toxin A HuMAbs (3H2, CDA1, and 1B11) could all inhibit the enterotoxicity of toxin A in mouse intestinal loops and the in vivo toxicity in a systemic mouse model. Four anti-toxin B HuMAbs (MDX-1388, 103-174, 1G10, and 2A11) could neutralize cytotoxicity in vitro, although systemic toxicity in the mouse could not be neutralized. Anti-toxin A HuMAb CDA1 and anti-toxin B HuMAb MDX-1388 were tested in the well-established hamster model of C. difficile disease. CDA1 alone resulted in a statistically significant reduction of mortality in hamsters; however, the combination treatment offered enhanced protection. Compared to controls, combination therapy reduced mortality from 100% to 45% (P\u3c0.0001) in the primary disease hamster model and from 78% to 32% (P\u3c0.0001) in the less stringent relapse model

Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance)

Clinically annotated specimens from cancer clinical trial participants offer an opportunity for discovery and validation of pharmacogenomic findings. The purpose of this observational study is to better understand patient/institution factors that may contribute to participation in the pharmacogenomic component of prospective cancer clinical trials

Reliability of dynamic contrast-enhanced magnetic resonance imaging data in primary brain tumours: a comparison of Tofts and shutter speed models

Purpose To investigate the robustness of pharmacokinetic modelling of DCE-MRI brain tumour data and to ascertain reliable perfusion parameters through a model selection process and a stability test. Methods DCE-MRI data of 14 patients with primary brain tumours were analysed using the Tofts model (TM), the extended Tofts model (ETM), the shutter speed model (SSM) and the extended shutter speed model (ESSM). A no-effect model (NEM) was implemented to assess overfitting of data by the other models. For each lesion, the Akaike Information Criteria (AIC) was used to build a 3D model selection map. The variability of each pharmacokinetic parameter extracted from this map was assessed with a noise propagation procedure, resulting in voxel-wise distributions of the coefficient of variation (CV). Results The model selection map over all patients showed NEM had the best fit in 35.5% of voxels, followed by ETM (32%), TM (28.2%), SSM (4.3%) and ESSM (<0.1%). In analysing the reliability of Ktrans, when considering regions with a CV<20%, ≈25% of voxels were found to be stable across all patients. The remaining 75% of voxels were considered unreliable. Conclusions The majority of studies quantifying DCE-MRI data in brain tumours only consider a single model and whole-tumour statistics for the output parameters. Appropriate model selection, considering tissue biology and its effects on blood brain barrier permeability and exchange conditions, together with an analysis on the reliability and stability of the calculated parameters, is critical in processing robust brain tumour DCE-MRI data

The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a period of increasing varicella vaccine coverage, 1998–2003

BACKGROUND: The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus. METHODS: In 1998–2003, as varicella vaccine uptake increased, incidence of varicella and herpes zoster in Massachusetts was monitored using the random-digit-dial Behavioral Risk Factor Surveillance System. RESULTS: Between 1998 and 2003, varicella incidence declined from 16.5/1,000 to 3.5/1,000 (79%) overall with ≥66% decreases for all age groups except adults (27% decrease). Age-standardized estimates of overall herpes zoster occurrence increased from 2.77/1,000 to 5.25/1,000 (90%) in the period 1999–2003, and the trend in both crude and adjusted rates was highly significant (p < 0.001). Annual age-specific rates were somewhat unstable, but all increased, and the trend was significant for the 25–44 year and 65+ year age groups. CONCLUSION: As varicella vaccine coverage in children increased, the incidence of varicella decreased and the occurrence of herpes zoster increased. If the observed increase in herpes zoster incidence is real, widespread vaccination of children is only one of several possible explanations. Further studies are needed to understand secular trends in herpes zoster before and after use of varicella vaccine in the United States and other countries