Is the Magyarmecske telluric conductivity anomaly a buried impact structure?

Abstract A more or less circular high-amplitude telluric conductivity anomaly is located at Magyarmecske, in southwestern Hungary. The authors collected and reinvestigated all available geophysical data previously measured in the area; based on this information it was concluded that the conductivity anomaly may well be explained as a buried impact crater. It is assumed that when the impact occurred, the target area was covered by a thick, coal-bearing Carboniferous sedimentary sequence. The projectile created a complex impact crater in these deposits, of a diameter of approximately 6–8 km. In the neighborhood of the crater the coal was modified by the impact's heat and pressure. Later the impact structure was partly eroded, partly deformed by younger tectonic movements, and covered by Neogene sediments of strongly variable thickness

Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary

<p>Abstract</p> <p>Aim</p> <p>The objective of this observational study was to assess the status of glycemic control and associated patient-reported outcomes in ambulatory Hungarian patients with type 2 diabetes mellitus (T2DM) who were prescribed either a sulfonylurea (SU) or a thiazolidinedione (TZD) in addition to the prior metformin (MF) monotherapy.</p> <p>Methods</p> <p>Type 2 diabetics aged ≥ 30 years and who had added an SU or TZD to previous MF monotherapy at least 1 year prior to the visit date were identified during January 2006 to March 2007. Information on HbA1c (A1C), medication use and co-morbid conditions was extracted from the medical record up to 6 months prior to the addition of SU or TZD to MF (baseline), and a minimum of one year after the initiation of either SU or TZD. Glycemic control (A1C < 6.5%) was assessed using the last available A1C value in the medical record. Self-reported hypoglycemia, health-related quality of life (HRQoL) and treatment satisfaction were also assessed.</p> <p>Results</p> <p>A total of 414 patients (82% SU+MF and 18% TZD+MF) with a mean age of 60.5 years (SD = 9.4 years) participated in the study. About 27% of patients reported hypoglycemic episodes, with about one-third reporting episodes that resulted into interruption of activities or required medical/non-medical assistance. Three quarters of patients were not at glycemic goal and BMI was the only factor significantly associated with failure to have an A1C level < 6.5%. Patients' HRQoL was significantly associated with self-reported hypoglycemic episodes (p = 0.017), and duration of diabetes (p = 0.045).</p> <p>Conclusion</p> <p>Nearly 75% of patients were not at A1C goal of < 6.5% despite using two oral anti-hyperglycemic medications. Approximately 9% of patients reporting hypoglycemia required some kind of medical/non-medical assistance. Greater BMI at baseline was associated with an A1C level ≥ 6.5%. Finally, self- reports of hypoglycemia and duration of diabetes were associated with low HRQoL.</p

A perm és a triász időszak határán lezajlott környezeti változások, magyarországi szelvények vizsgálata alapján = Environmental changes at the Permian-Triassic boundary, based on studies of boundary sections in Hungary

Kutatási programunk célja az volt, hogy képet nyerjünk a paleozoikum és a mezozoikum határán lejátszódó, a fanerozoikum legnagyobb kihalásához vezető környezeti változások pontos menetéről és ennek alapján megkíséreljük az okok feltárását is. A bükki szelvények vizsgálata során biosztratigráfiai módszerekkel tisztáztuk a határ pontos helyzetét, részletes mikrofácies-elemzést végeztünk. Kimutattuk, hogy a legfelső perm rétegekben a karbonátkiválasztó szervezetek maradványai rövid szakaszon belül, de fokozatosan tünnek el. A maradványok eltűnésével együtt kezdődik el a delta 13C értékek fokozatos eltolódása negatív irányba. Az ezt követő szakaszt elszegényedett fosszilia-együttes és litológiai változás ("határ márga") is jellemzi. A "túlélő" permi szervezetek eltűnése egybeesik a delta 13C értékek negatív csúcsával, amit a P-T határ kemosztratigráfiai jelzőjének tekintenek. Negatív eltolódás az erős vízmozgású sekélytengerben képződött dunánúli-középhegységi rétegsorok ooidos határszakaszán is egyértelműen kimutatható. A triász kezdetén mikrobás karbonátok, illetve a sekély, erős vizmozgású szubtidális övezetekben oolit rétegek képződése jellemző. Az eredmények bebizonyították, hogy a Bálvány-észak elnevezésű alapszelvény a perm és a triász határán lezajlott események megismerése szempontjából az egyik legteljesebb és a legjobban tanulmányozható szelvény Európában és világviszonylatban is kiemelkedő jelentőségű. | The aim of the research project was to contribute for better understanding of environmental changes, which resulted in the largest extension of the Phanerozoic at the boundary between the Paleozoic and Mesozoic. Applying biostratigraphic methods, the exact position of the boundary was determined in the sections of the Bükk Mountains and detailed microfacies analyses were carried out. It was proved that in the uppermost Permian layers, remnants of carbonate secreting organisms gradually disappear in a short interval. A negative shift of delta 13C values starts at the level of onset of gradual decrease in the amount of bioclasts. The next interval is characterised by an impoverished fossil assemblage and also a change in the lithology ('boundary shale'). Disappearance of the 'survivor' Permian biota coincides with a negative delta 13C peak that is considered as the chemostratigraphic marker of the Permian-Triassic boundary. The negative shift was also encountered in the oolitic boundary interval of the Transdanubian Range, which was deposited in a high-energy shallow marine environment. In the earliest Triassic formation of microbial carbonates on the low-energy sea-bottom and oolites in the high-energy environments was typical. Results of the project evidenced that the Bálvány-North section is one of the most complete and best-exposed Permian-Triassic boundary sections in Europe and it has an outstanding importance world-wide

Age-associated differences in the human lung extracellular matrix

Extracellular matrix (ECM) remodeling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung ECM is currently limited. In this study, we aimed to identify and localize age-associated ECM differences in human lungs using comprehensive transcriptomic, proteomic, and immunohistochemical analyses. Our previously identified age-associated gene expression signature of the lung was re-analyzed limiting it to an aging signature based on 270 control patients (37-80 years) and focused on the Matrisome core geneset using geneset enrichment analysis. To validate the age-associated transcriptomic differences on protein level, we compared the age-associated ECM genes (false discovery rate, FDR &lt; 0.05) with a profile of age-associated proteins identified from a lung tissue proteomics dataset from nine control patients (49-76 years) (FDR &lt; 0.05). Extensive immunohistochemical analysis was used to localize and semi-quantify the age-associated ECM differences in lung tissues from 62 control patients (18-82 years). Comparative analysis of transcriptomic and proteomic data identified seven ECM proteins with higher expression with age at both gene and protein levels: COL1A1, COL6A1, COL6A2, COL14A1, FBLN2, LTBP4, and LUM. With immunohistochemistry, we demonstrated higher protein levels with age for COL6A2 in whole tissue, parenchyma, airway wall, and blood vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in lung parenchyma. Our study revealed that higher age is associated with lung ECM remodeling, with specific differences occurring in defined regions within the lung. These differences may affect lung structure and physiology with aging and as such may increase susceptibility to developing chronic lung diseases. NEW &amp; NOTEWORTHY We identified seven age-associated extracellular matrix (ECM) proteins, i.e., COL1A1, COL6A1, COL6A2 COL14A1, FBLN2, LTBP4, and LUM with higher transcript and protein levels in human lung tissue with age. Extensive immunohistochemical analysis revealed significant age-associated differences for COL6A2 in whole tissue, parenchyma, airway wall, and vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in parenchyma. Our findings lay a new foundation for the investigation of ECM differences in age-associated chronic lung diseases. </p

Age-associated differences in the human lung extracellular matrix

Extracellular matrix (ECM) remodeling has been associated with chronic lung diseases. However, information about specific age-associated differences in lung ECM is currently limited. In this study, we aimed to identify and localize age-associated ECM differences in human lungs using comprehensive transcriptomic, proteomic, and immunohistochemical analyses. Our previously identified age-associated gene expression signature of the lung was re-analyzed limiting it to an aging signature based on 270 control patients (37-80 years) and focused on the Matrisome core geneset using geneset enrichment analysis. To validate the age-associated transcriptomic differences on protein level, we compared the age-associated ECM genes (false discovery rate, FDR &lt; 0.05) with a profile of age-associated proteins identified from a lung tissue proteomics dataset from nine control patients (49-76 years) (FDR &lt; 0.05). Extensive immunohistochemical analysis was used to localize and semi-quantify the age-associated ECM differences in lung tissues from 62 control patients (18-82 years). Comparative analysis of transcriptomic and proteomic data identified seven ECM proteins with higher expression with age at both gene and protein levels: COL1A1, COL6A1, COL6A2, COL14A1, FBLN2, LTBP4, and LUM. With immunohistochemistry, we demonstrated higher protein levels with age for COL6A2 in whole tissue, parenchyma, airway wall, and blood vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in lung parenchyma. Our study revealed that higher age is associated with lung ECM remodeling, with specific differences occurring in defined regions within the lung. These differences may affect lung structure and physiology with aging and as such may increase susceptibility to developing chronic lung diseases. NEW &amp; NOTEWORTHY We identified seven age-associated extracellular matrix (ECM) proteins, i.e., COL1A1, COL6A1, COL6A2 COL14A1, FBLN2, LTBP4, and LUM with higher transcript and protein levels in human lung tissue with age. Extensive immunohistochemical analysis revealed significant age-associated differences for COL6A2 in whole tissue, parenchyma, airway wall, and vessel, for COL14A1 and LUM in bronchial epithelium, and COL1A1 in parenchyma. Our findings lay a new foundation for the investigation of ECM differences in age-associated chronic lung diseases. </p

Supplementary file 1.xlsx

Complete list of Transcriptomic analysis result. To determine the association between age and ECM gene expression, we first assessed the age-associated gene expression differences in the non-disease control lung tissues. In total 4201 probes corresponding to 4147 unique genes were significantly associated with age; of which 2247 probes coding for 2226 genes showed a higher and 1954 probes coding for 1939 genes a lower gene expression with higher ag

Supplementary materials for the manuscript "Age-associated Differences in Human Lung Extracellular Matrix"

This supplemenatary documents show additional results from our manuscript that may be interesting for our audience