Flow chart for the enrollment of the study population and the SNP analysis.

<p>Flow chart for the enrollment of the study population and the SNP analysis.</p

Association of <i>CORIN</i> rs2271036 and rs2271037 single nucleotide polymorphisms (SNPs) with preeclampsia (PE).

<p>Results are given in the discovery (S1), replication (S2) and combined (C) samples, in Caucasian subjects from Europe (Eur), Maghreb (Mgh) or Sub-Saharan-African subjects (Afr).</p><p><b>*</b>Genotypes are expressed as percentage (number) of patients with TT/TC/CC genotype for rs2271036 and as TT/TG/GG genotype for rs2271037, respectively.</p>†<p>ORs (95% IC, p values) calculated in a dominant model, adjusted for nulliparity and obesity, associated with the (CC+CT) versus the TT genotype (rs2271036) or with the (GG+GT) versus the TT genotype (rs2271037). MAF, minor allele frequency.</p>‡<p>Significantly different when compared to the control group (chi-square test adjusted for nulliparity and obesity).</p><p>Association of <i>CORIN</i> rs2271036 and rs2271037 single nucleotide polymorphisms (SNPs) with preeclampsia (PE).</p

Quality control for the 19 <i>CORIN</i> single nucleotide polymorphisms (SNPs) found in the discovery sample (sample 1, n = 260).

<p>For each SNP, position on chromosome 4, minor allele frequencies (MAF) in both ethnic groups of subjects and results of testing for departure from Hardy Weinberg equilibrium (<i>p</i> (HWE)). Both SNPs of interest (rs2271036 and rs2271037) are in bold. SNPs with MAF below 1% in Caucasians are in italics.</p><p>del, deletion.</p><p>*Caucasian from Europe or Maghreb.</p>†<p>Sub-Saharan African patients.</p>‡<p>Genotypic association with preeclampsia in a dominant model: conditional logistic regression analysis adjusted for nulliparity and obesity.</p><p>Quality control for the 19 <i>CORIN</i> single nucleotide polymorphisms (SNPs) found in the discovery sample (sample 1, n = 260).</p

Combined genotype and haplotype frequencies of the V249I and T280M polymorphisms of the CX3CR1 gene in cases and controls.

<p>Values are percentages of subjects (number) or haplotypes. NA not analysed because of small number of subjects (n≤3 per group).</p>*<p>ORs adjusted for PE risk factors.</p

Genotype, combined genotype and haplotype frequencies of the V249I and T280M polymorphisms of the CX3CR1 gene in the preeclampsia group, distributed according to severity and time of onset.

<p>Values are the percentage of subjects (number) and haplotypes. PE, preeclampsia. NS, non severe.</p>*<p>ORs associated with the (II+VI) <i>versus</i> the VV genotype and with the (MM+TM) <i>versus</i> the TT genotype are adjusted for the other polymorphism.</p>†<p>Chi² comparison for the 3 common combined genotypes.</p>$<p>Chi² comparison for the 3 haplotypes.</p

Mean maternal plasma concentrations of VWF:Ag, Thrombomodulin, VCAM-1 and CX3CL1 in paired cases and controls.

<p>Values are mean±SD. Some variation in numbers due to missing data. VWF:Ag, von Willebrand factor antigen; VCAM-1, soluble vascular cell adhesion molecule-1; CX3CL1 (soluble form). Odds ratios are calculated for 10 units of each parameter.</p

Laboratory marker concentrations according to gestational age at enrolment.

<p>Enrolment was done at the onset of preeclampsia for cases, and at matched gestational age for controls.</p><p>Values are mean±SD. VWF:Ag, von Willebrand factor antigen; VCAM-1, soluble vascular cell adhesion molecule-1.</p>*<p>gestational age is given in weeks.</p

Demographic, obstetrical and medical characteristics of the study population.

<p>Some variation in number owing to missing data. BMI, body mass index; NA, not applicable; GW, gestation weeks; APLS, antiphospholipid syndrome. Fetal growth restriction <3d centile.</p

Genotype frequencies of the V249I and T280M polymorphisms of the CX3CR1 gene in cases and controls.

*<p>ORs (95% CI, p values) adjusted for PE risk factors, associated with the (II+VI) <i>versus</i> the VV genotype and with the (MM+TM) <i>versus</i> the TT genotype.</p>**<p>ORs (95% CI, p values) further adjusted for the other polymorphism.</p