Dynamic one-sided out-of-plane behavior of unreinforced-masonry wall restrained by elasto-plastic tie-rods

Past earthquakes have shown the high vulnerability of existing masonry buildings, particularly to out-of-plane local collapse mechanisms. Such mechanisms can be prevented if façades are restrained by tie rods improving the connections to perpendiculars walls. Whereas in the past only static models have been proposed, herein the nonlinear equation of motion of a monolithic wall restrained by a tie rod is presented. The façade, resting on a foundation and adjacent to transverse walls, rotates only around one base pivot and has one degree of freedom. Its thickness is explicitly accounted for and the tie rod is modeled as a linear elastic—perfectly plastic spring, with limited displacement capacity. The model is used to investigate the response to variations of wall geometry (height/thickness ratio, thickness), tie rod features (vertical position, length, prestress level), and material characteristics (elastic modulus, ultimate elongation, yield strength) typical of historical iron. The most relevant parameter is the steel strength, whereas other characteristics play minor roles allowing to recommend reduced values for pre-tensioning forces. The force-based procedure customary in Italy for tie design is reasonably safe and involves protection also against collapse, although probably not enough as desirable

Effect of ground-motion sequences on a unreinforced masonry wall restrained by an elasto-plastic tie-rod

This work investigates the effect of international ground-motion sequences on the out-of-plane response of an ordinary-building façade. The following assumptions are made on the wall boundary conditions: the wall is resting on a foundation, it is adjacent to transverse walls and restrained by elasto-plastic tie rods with finite elongation capacity. Four walls are considered of different aspect ratio and size; two types of masonry are assumed, and the tie is designed following a force-based procedure according to the Commentary to the Italian Building Code. The walls are modelled as rigid blocks of finite thickness and free to rotate on one side only. The rocking response of the walls, excited in the out-of-plane direction under 56 sequences of records, is evaluated. The effect of sequences is estimated by the comparison of the response experienced during the sequence and under a single record, strongest in terms of either peak ground acceleration or velocity. Finally, in order to reduce the vulnerability originated by a seismic sequence, a proposal of a reduced behaviour factor to be adopted in the design of tie rods is formulated

Combined ND techniques for structural assessment: the case of historic Nepali constructions after the 2015 Gorkha earthquake

Combined non-destructive in situ techniques—namely sonic tests and ambient vibration measurements—are applied on two Nepali Pagoda temples damaged by the 2015 Gorkha earthquake, providing the dynamic elastic modulus of masonry and the buildings' frequencie

Effect of the vertical component of ground motion on a rubble masonry wall model

In this paper the influence of the vertical component of ground motion on the performance of an unreinforced masonry wall is analysed using sets of one-component and two-component ground motions. The set of motions represents the actual seismicity of L'Aquila, while the investigated wall mimics an experimental specimen with two unconnected external leaves and a rubble core. The model falls within the mixed finite element method – discrete element method and accounts for crack formation, complete separation and new contact formation. The modelling strategy is capable to simulate the out-of-plane seismic response and the progressive loss of compactness of the wall up to collapse with the separation between the two external leaves. The vertical component increases the fragility of the wall and confirms the relevance of vertical ground motion for very vulnerable constructions. Nonetheless, to worsen the response, the vertical component needs to overcome specific, non-negligible intensity measure thresholds

Nonlinear macroelement based on Bouc-Wen formulation with degradation for the equivalent frame modelling of masonry walls

The equivalent frame model takes into account the shear and bending mechanisms that take place in piers and spandrels through plastic hinges. It represents a good compromise between accuracy and computational burden in the analysis of complex masonry walls. For the purposes of dynamic analysis, in addition to the hysteretic behaviour of the plastic hinges, it is also necessary to introduce their degradation of strength and stiffness. This study presents a macroelement model for piers and spandrels in which the bending mechanism is described by two hinges at the ends of the macroelement, and the shear mechanism by a shear link. They are characterized by a hysteretic behaviour with progressive plasticity, described by the Bouc-Wen model, and by degradation of strength and stiffness. Degradation is described through a damage parameter, which governs both strength and stiffness decay, and a flexibility increase parameter, which only governs stiffness reduction. In this way it is possible to independently control both strength and stiffness degradation. The model is applied to simulate experimental tests on panels, highlighting a good agreement with the experimental results

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration

Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration. In all these disorders excitotoxicity is a prominent component of neuronal damage, but clinical data discourage the development of NMDA receptor antagonists as neuroprotectants. Here, we show that activation of mGlu1 metabotropic glutamate receptors largely contributes to excitotoxic degeneration of RGCs. Mice at postnatal day 9 were challenged with a toxic dose of monosodium glutamate (MSG, 3g/kg), which caused the death of >70% of Brn-3a+ RGCs. Systemic administration of the mGlu1 receptor negative allosteric modulator (NAM), JNJ16259685 (2.5mg/kg, s.c.), was largely protective against MSG-induced RGC death. This treatment did not cause changes in motor behavior in the pups. We also injected MSG to crv4 mice, which lack mGlu1 receptors because of a recessive mutation of the gene encoding the mGlu1 receptor. MSG did not cause retinal degeneration in crv4 mice, whereas it retained its toxic activity in their wild-type littermates. These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of RGCs, and encourage the study of mGlu1 receptor NAMs in models of retinal neurodegeneration

Role of brain perfusion SPECT with 99mTc HMPAO in the assessment of response to drug therapy in patients with autoimmune vasculitis: a prospective study

Abstract BACKGROUND: The diagnosis of vasculitis in the brain remains a quite difficult achievement. To the best of our knowledge, there is no imaging method reported in literature which is capable of reaching to a diagnosis of vasculitis with very high sensitivity. AIM: The aim of this study was to determine whether perfusion brain single photon emission computed tomography (SPECT) can be usefully employed in monitoring the treatment of vasculitis, allowing treating only potentially responder patients and avoiding the side effects on patients who do not respond. MATERIALS AND METHODS: Twenty patients (two males and 18 females) suffering from systemic lupus erythematosus (SLE; n = 5), Behcet's disease (BD; n = 5), undifferentiated vasculitis (UV; n = 5), and Sjogren's syndrome (SS; n = 5) were included in the study. All patients underwent a wide neurological anamnestic investigation, a complete objective neurological examination and SPECT of the brain with 99mTc-hexamethyl-propylene-aminoxime (HMPAO). The brain SPECT was then repeated after appropriate medical treatment. The neurological and neuropsychiatric follow-up was performed at 6 months after the start of the treatment. RESULTS: Overall, the differences between the scintigraphic results obtained after and before the medical treatment indicated a statistically significant increase of the cerebral perfusion (CP). In 19 out of 200 regions of interest (ROI) studied, the difference between pre- and post treatment percentages had negative sign, indicating a worsening of CP. This latter event has occurred six times (five in the same patients) in the UV, 10 times (eight in the same patients) in the SLE, never in BD, and three times (two in the same patient) in the SS. CONCLUSION: The reported results seem to indicate the possibility of identifying, by the means of a brain SPECT, responder and nonresponder (unchanged or worsened CP) patients, affected by autoimmune vasculitis, to the therapy

Shake table testing of a low-impact technology for the seismic protection of stone masonry

This paper presents a novel low-impact technique for the seismic protection of fair-face masonry walls. The proposed strengthening solution involves the use of carbon-fibre reinforced polymer (CFRP) connectors installed from the outside by perforating the stone elements, combined with grout injections. The connectors cover ¾ of the wall thickness, so as to leave the inner surface undisturbed. Once the work is completed, they are also substantially invisible. Shake table tests were carried out under natural accelerograms on two full-scale irregular multi-leaf stone masonry wall specimens. In order to replicate materials and construction technique of the Apennine historical buildings, the prototypes were made from stones recovered from the debris of a settlement in the municipality of Accumoli (RI, Italy), and the mortar was designed to reproduce lime-poor mortars surveyed in the field. The experimental setup was designed to induce out-of-plane vertical bending under base seismic motion, while allowing the vertical displacement of the wall top. One specimen was tested “as-built” and the other one was tested strengthened, to investigate the gain in seismic performance, the limitation of progressive damage accumulation and the effects on dynamic properties

Methods and approaches for blind test predictions of out-of-plane behavior of masonry walls: a numerical comparative study

Earthquakes cause severe damage to masonry structures due to inertial forces acting in the normal direction to the plane of the walls. The out-of-plane behavior of masonry walls is complex and depends on several parameters, such as material and geometric properties of walls, connections between structural elements, the characteristics of the input motions, among others. Different analytical methods and advanced numerical modeling are usually used for evaluating the out-of-plane behavior of masonry structures. Furthermore, different types of structural analysis can be adopted for this complex behavior, such as limit analysis, pushover, or nonlinear dynamic analysis.Aiming to evaluate the capabilities of different approaches to similar problems, blind predictions were made using different approaches. For this purpose, two idealized structures were tested on a shaking table and several experts on masonry structures were invited to present blind predictions on the response of the structures, aiming at evaluating the available tools for the out-of-plane assessment of masonry structures. This article presents the results of the blind test predictions and the comparison with the experimental results, namely in terms of formed collapsed mechanisms and control outputs (PGA or maximum displacements), taking into account the selected tools to perform the analysis.info:eu-repo/semantics/publishedVersio

Association of Genetic Markers with CSF Oligoclonal Bands in Multiple Sclerosis Patients

Objective:to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients.Methods:We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Finally, we performed a Genome Wide Association Study (GWAS) with OCB status on a subset of 562 patients. The best associated SNPs of the Italian GWAS were replicated in silico in Scandinavian and Belgian populations, and meta-analyzed.Results:HLA-DRB1*15 is associated with OCB+: p = 0.03, Odds Ratio (OR) = 1.6, 95% Confidence Limits (CL) = 1.1-2.4. None of the 52 non-HLA MS susceptibility loci was associated with OCB, except one SNP (rs2546890) near IL12B gene (OR: 1.45; 1.09-1.92). The weighted Genetic Risk Score mean was significantly (p = 0.0008) higher in OCB+ (7.668) than in OCB- (7.412) patients. After meta-analysis on the three datasets (Italian, Scandinavian and Belgian) for the best associated signals resulted from the Italian GWAS, the strongest signal was a SNP (rs9320598) on chromosome 6q (p = 9.4×10-7) outside the HLA region (65 Mb).Discussion:genetic factors predispose to the development of OCB