Dwork families and D\mathcal{D}-modules

A Dwork family is a one-parameter monomial deformation of a Fermat hypersurface. In this paper we compute algebraically the invariant part of its Gauss-Manin cohomology under the action of certain subgroup of automorphisms. To achieve that goal we use the algebraic theory of $\mathcal{D}$-modules, especially one-dimensional hypergeometric ones.Comment: 24 pages, final versio

Irregular Hodge filtration of some confluent hypergeometric systems

We determine the irregular Hodge filtration, as introduced by Sabbah, for the purely irregular hypergeometric $\mathcal{D}$-modules. We obtain in particular a formula for the irregular Hodge numbers of these systems. We use the reduction of hypergeometric systems from GKZ-systems as well as comparison results to Gauss-Manin systems of Laurent polynomials via Fourier-Laplace and Radon transformations.Comment: 32 pages, final versio

Dwork families and D-modules

A Dwork family is a one-parameter monomial deformation of a Fermat hypersurface. In this paper we compute algebraically the invariant part of its Gauss–Manin cohomology under the action of certain subgroup of automorphisms. To achieve that goal we use the algebraic theory of D-modules, especially one-dimensional hypergeometric ones.Junta de Andalucía P12-FQM-2696Ministerio de Economía y Competitividad MTM2013-46231-PAgence Nationale de la Recherche 13-IS01- 0001-01/02Deutsche Forschungsgemeinschaft HE 2287/4-1, SE 1114/5-

On the reduced Bernstein-Sato polynomial of Thom-Sebastiani singularities

Given two holomorphic functions $f$ and $g$ defined in two respective germs of complex analytic manifolds $(X,x)$ and $(Y,y)$, we know thanks to M. Saito that, as long as one of them is Euler homogeneous, the reduced (or microlocal) Bernstein-Sato polynomial of the Thom-Sebastiani sum $f+g$ can be expressed in terms of those of $f$ and $g$. In this note we give a purely algebraic proof of a similar relation between the whole functional equations that can be applied to any setting (not necessarily analytic) in which Bernstein-Sato polynomials can be defined.Comment: 8 pages, final versio

Sensitivity of the Cherenkov Telescope Array to a dark matter signal from the Galactic centre

We provide an updated assessment of the power of the Cherenkov Telescope Array (CTA) to search for thermally produced dark matter at the TeV scale, via the associated gamma-ray signal from pair-annihilating dark matter particles in the region around the Galactic centre. We find that CTA will open a new window of discovery potential, significantly extending the range of robustly testable models given a standard cuspy profile of the dark matter density distribution. Importantly, even for a cored profile, the projected sensitivity of CTA will be sufficient to probe various well-motivated models of thermally produced dark matter at the TeV scale. This is due to CTA's unprecedented sensitivity, angular and energy resolutions, and the planned observational strategy. The survey of the inner Galaxy will cover a much larger region than corresponding previous observational campaigns with imaging atmospheric Cherenkov telescopes. CTA will map with unprecedented precision the large-scale diffuse emission in high-energy gamma rays, constituting a background for dark matter searches for which we adopt state-of-the-art models based on current data. Throughout our analysis, we use up-to-date event reconstruction Monte Carlo tools developed by the CTA consortium, and pay special attention to quantifying the level of instrumental systematic uncertainties, as well as background template systematic errors, required to probe thermally produced dark matter at these energies

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research