1,011 research outputs found

    Altered expression of the voltage-gated calcium channel subunit Ī±2Ī“-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.

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    The auxiliary Ī±2Ī“-1 subunit of voltage-gated calcium channels is up-regulated in dorsal root ganglion neurons following peripheral somatosensory nerve damage, in several animal models of neuropathic pain. The Ī±2Ī“-1 protein has a mainly presynaptic localization, where it is associated with the calcium channels involved in neurotransmitter release. Relevant to the present study, Ī±2Ī“-1 has been shown to be the therapeutic target of the gabapentinoid drugs in their alleviation of neuropathic pain. These drugs are also used in the treatment of certain epilepsies. In this study we therefore examined whether the level or distribution of Ī±2Ī“-1 was altered in the hippocampus following experimental induction of epileptic seizures in rats, using both the kainic acid model of human temporal lobe epilepsy, in which status epilepticus is induced, and the tetanus toxin model in which status epilepticus is not involved. The main finding of this study is that we did not identify somatic overexpression of Ī±2Ī“-1 in hippocampal neurons in either of the epilepsy models, unlike the upregulation of Ī±2Ī“-1 that occurs following peripheral nerve damage to both somatosensory and motor neurons. However, we did observe local reorganisation of Ī±2Ī“-1 immunostaining in the hippocampus only in the kainic acid model, where it was associated with areas of neuronal cell loss, as indicated by absence of NeuN immunostaining, dendritic loss, as identified by areas where microtubule-associated protein-2 immunostaining was missing, and reactive gliosis, determined by regions of strong OX42 staining

    The use of imaging systems to monitor shoreline dynamics

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    The development of imaging systems is nowadays established as one of the most powerful and reliable tools for monitoring beach morphodynamics. Two different techniques for shoreline detection are presented here and, in one case, applied to the study of beach width oscillations on a sandy beach (Pauanui Beach, New Zealand). Results indicate that images can provide datasets whose length and sample interval are accurate enough to resolve inter-annual and seasonal oscillations, and long-term trends. Similarly, imaging systems can be extremely useful in determining the statistics of rip current occurrence. Further improvements in accuracy and reliability are expected with the recent introduction of digital systems

    Optical identification of the companion to PSR J1911-5958A, the pulsar binary in the outskirts of NGC 6752

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    We report on the identification of the optical counterpart of the binary millisecond pulsar PSR J1911-5958A, located in the outskirts of the globular cluster NGC 6752. At the position of the pulsar we find an object with V=22.08, B-V=0.38, U-B=-0.49. The object is blue with respect to the cluster main sequence by 0.8 magnitudes in B-V. We argue that the object is the white dwarf companion of the pulsar. Comparison with white dwarf cooling models shows that this magnitude and colors are consistent with a low-mass white dwarf at the distance of NGC 6752. If associated with NGC 6752, the white dwarf is relatively young, <2 Gyr, which sets constraints on the formation of the binary and its ejection from the core of the globular cluster.Comment: Accepted for publication in A&A Letters (September 1st, 2003

    RR Lyrae stars in four globular clusters in the Fornax dwarf galaxy

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    (Abridged) We have surveyed four globular clusters in the Fornax dwarf galaxy for RR Lyrae stars, using archival HST observations. We identify 197 new RR Lyrae stars in these four clusters. Despite the short observational baseline, we derive periods, light-curves, and photometric parameters for each. The Fornax clusters have exceptionally large RR Lyrae specific frequencies compared with the Galactic globular clusters. Furthermore, the Fornax cluster RR Lyrae stars are unusual in that their characteristics are intermediate between the two Galactic Oosterhoff groups. In this respect the Fornax clusters are similar to the field populations in several dwarf galaxies. We revise previous measurements of the HB morphology in each cluster. The Fornax clusters closely resemble the ``young'' Galactic halo population defined by Zinn. The existence of the second parameter effect among the Fornax clusters is also confirmed. Finally, we determine foreground reddening and distance estimates for each cluster. We find a mean distance modulus to Fornax of (m-M)_0 = 20.66 +/- 0.03 (random) +/- 0.15 (systematic). Our measurements are consistent with a line of sight depth of 8-10 kpc for this galaxy, matching its projected dimensions, and incompatible with tidal model explanations for the observed high velocity dispersions in many dSph galaxies. Dark matter dominance is suggested.Comment: 26 pages, 6 figures. Accepted for publication in MNRAS. Table 2 and Figure 2 will only be available in the electronic version. On-line data will soon be available at http://www.ast.cam.ac.uk/STELLARPOPS/Fornax_RRlyr
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