Online Yoga-Based and Standard Exercises for Patients with a Rotator Cuff Injury Awaiting Surgery: A Feasibility Study

This study investigates the feasibility of conducting a 6-week intervention program comparing online yoga-based and standard exercises among 10 injured pre-surgery rotator cuff patients. Case reports on two patients are presented to demonstrate implementation and potential consequences of both interventions. A feasibility study was conducted after recruiting 10 patients from surgical wait list of 51 patients. Patients in both studies were assessed for shoulder flexion, abduction and external rotation range of motion and strength at aseline and 6- weeks. The SPADI questionnaire was used to assess pain/function. Most (8/10) patients in the feasibility study did not complete the full protocol. One caseworsened (yoga), while another (standard exercise) improved in strength. This does not indicate relative efficacy. SPADI results were changed by less than 10%indicating no clinically important change. Qualitative feedback suggested that patients might be open to online exercises. Developmental work is needed to define a easible intervention/study design

Staging Orthodontic Aligners for Complex Orthodontic Tooth Movement

The recent trend in orthodontics has shown an increased shift toward aligner therapy. For years, orthodontists have used fixed preadjusted appliances for orthodontic treatment. Even though fixed appliances have been highly efficient in the treatment of orthodontic malocclusions, they are not as esthetic as clear aligners. The purpose of this article is to review the staging of orthodontic tooth movement (OTM) with aligner therapy

Class III Malocclusion Treated by Combined Orthodontic and Orthognathic Approach Along with Growth Prediction: A Case Report

To devise a comprehensive treatment strategy for patients with Class III malocclusion, it is critical to address etiology in the process of differential diagnosis. Growth prediction has always been a part of the deduction science. It is important not only in treatment planning and treatment provision, but it is equally important in the evaluation of prognosis during retention and after retention. The visual treatment objective by Ricketts is a complete analysis and the first of its kind defining every aspect of malocclusion and also assessing where the etiology lies. Here, we present one such case of skeletal Class III in which the growth prediction has played a vital role in the comprehensive treatment planning and treatment outcome

A genome-wide structure-based survey of nucleotide binding proteins in M. tuberculosis

Nucleoside tri-phosphates (NTP) form an important class of small molecule ligands that participate in, and are essential to a large number of biological processes. Here, we seek to identify the NTP binding proteome (NTPome) in M. tuberculosis (M.tb), a deadly pathogen. Identifying the NTPome is useful not only for gaining functional insights of the individual proteins but also for identifying useful drug targets. From an earlier study, we had structural models of M.tb at a proteome scale from which a set of 13,858 small molecule binding pockets were identified. We use a set of NTP binding sub-structural motifs derived from a previous study and scan the M.tb pocketome, and find that 1,768 proteins or 43% of the proteome can theoretically bind NTP ligands. Using an experimental proteomics approach involving dye-ligand affinity chromatography, we confirm NTP binding to 47 different proteins, of which 4 are hypothetical proteins. Our analysis also provides the precise list of binding site residues in each case, and the probable ligand binding pose. As the list includes a number of known and potential drug targets, the identification of NTP binding can directly facilitate structure-based drug design of these targets

Role of Moringa oleifera in regulation of diabetes-induced oxidative stress

AbstractObjectiveTo evaluate the antioxidant activity of aqueous extract ofMoringa oleifera (M. oleifera) young leaves by in vivo as well as in vitro assays.MethodsIn vitro study included estimation of total phenolic, total flavonol, total flavonoid and total antioxidant power (FRAP assay). In addition, in vivo study was done with the identified most effective dose of 200 mg/kg of its lyophilized powder on normal and diabetic rats. Its effect on different oxidative free radical scavenging enzymes,viz, superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), lipid peroxide (LPO) contents were measured.ResultsSignificant increase in activities of SOD, CAT, GST while, a decrease in LPO content was observed. Whereas, total phenolic, flavonoid and flavonol contents in the extract were found to be 120 mg/g of GAE, 40.5 mg/g of QE and 12.12 mg/g of QE, respectively. On the other hand, FRAP assay results ofM. oleifera leaves was (85.00±5.00)μM/g of extract powder.ConclusionsThe significant antioxidant activities ofM. oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage