256 research outputs found
Youth entrepreneursh1p: definitions, challenges and prospects of development
The article deals with the definition of Β«youth entrepreneurshipΒ», age stages and psychological types of young entrepreneurs. The authors highlighted the barriers of youth entrepreneurs hip and ways of overcoming them.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ½ΡΡΠΈΡ Β«ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠ½ΠΎΠ΅ ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΠ΅Π»ΡΡΡΠ²ΠΎΒ», Π²ΠΎΠ·ΡΠ°ΡΡΠ½ΡΠ΅ ΡΡΠ°Π΄ΠΈΠΈ ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΏΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ
ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΠ΅Π»Π΅ΠΉ. ΠΡΠ΄Π΅Π»Π΅Π½Ρ Π±Π°ΡΡΠ΅ΡΡ ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΠΈΠΌΠ°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΌΠΎΠ»ΠΎΠ΄Π΅ΠΆΠΈ ΠΈ ΠΏΡΡΠΈ ΠΈΡ
ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ
Supersymmetric vertex algebras
We define and study the structure of SUSY Lie conformal and vertex algebras.
This leads to effective rules for computations with superfields.Comment: 71 page
Semirigid Geometry
We provide an intrinsic description of -super \RS s and -\SR\
surfaces. Semirigid surfaces occur naturally in the description of topological
gravity as well as topological supergravity. We show that such surfaces are
obtained by an integrable reduction of the structure group of a complex
supermanifold. We also discuss the \s moduli spaces of -\SR\ surfaces and
their relation to the moduli spaces of -\s\ \RS s.Comment: 29p
Exposure of vanadium as a factor of adverse activation of lymphocytes
We have estimated effect of vanadium influence on apoptosis of peripheral blood lymphocytes among workers. Immunologic assessment have allowed establishing that people working under the conditions of vanadium exposure have significantly increased quantity of annexin-positive cells indicating apoptosis in comparison with a reference group of people. We have identified statistically significant adverse mobilization of lymphocytes in respondents who have been working under conditions of the hazardous industry over 10 years. Therefore, the level and duration of the vanadium exposure influenced by the length of em plopent increase the immune system dysfunction degree.ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ Π²Π°Π½Π°Π΄ΠΈΡ Π½Π° ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ Π³ΠΈΠ±Π΅Π»Ρ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Ρ ΡΠ°Π±ΠΎΡΠ°ΡΡΠΈΡ
. ΠΡΠ΅Π½ΠΊΠ° ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ° ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»Π° ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ, ΡΡΠΎ Ρ ΡΠ°Π±ΠΎΡΠ°ΡΡΠΈΡ
Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΠΈ Π²Π°Π½Π°Π΄ΠΈΠ΅ΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π°Π½Π½Π΅ΠΊΡΠΈΠ½-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΎΠ± Π°ΠΏΠΎΠΏΡΠΎΠ·Π΅, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ Π³ΡΡΠΏΠΏΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ. ΠΡΡΠ²Π»Π΅Π½Π° ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ Π½Π΅Π³Π°ΡΠΈΠ²Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² Ρ ΠΎΠ±ΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
, ΡΠ΅ΠΉ ΡΡΠ°ΠΆ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
Π²ΡΠ΅Π΄Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π° ΠΏΡΠ΅Π²ΡΡΠ°Π» 10 Π»Π΅Ρ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΡΠΎΠ²Π΅Π½Ρ ΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΡΠΊΡΠΏΠΎΠ·ΠΈΡΠΈΠΈ Π²Π°Π½Π°Π΄ΠΈΠ΅ΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΠ°Ρ ΡΡΠ°ΠΆΠ΅ΠΌ ΡΠ°Π±ΠΎΡΡ, ΡΡΡΠ³ΡΠ±Π»ΡΠ΅Ρ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ
Epidemiological situation on tuberculosis among the children and teenage population 159 (review of literature)
Tuberculosis is nowadays one of the most actual problems of world public health, service. According to the data of WHO, one third of world's population is infected, with tuberculosis microbacteria. Every year 2-3 millions of people die because of tuberculosis. During last years in Russia tuberculosis morbidity increased 2,3 times, mortality - 1,9 times and prevalence - 4 %. Aggravation of epidemiological situation on tuberculosis is characterized by increase of morbidity among all age groups and especially among the children. In Irkutsk region epidemiological situation on tuberculosis is still intensive. Main reasons of unsatisfactory indices of tuberculosis in Irkutsk region are: presence of significant reservoir of tuberculosis infection among the population. of the region; significant level of prevalence of HIV-infection; unsatisfactory material and technical base of antituberculous institutions of the region; personnel deficiency in antituberculous institutions; insufficient level of preventive measures in foci of tuberculosis infection; absence of modern, medical informational system in antituberculous institutions of the region. To optimize the situation at the development of antituberculous measures it is necessary to take into account regional peculiarities of epidemic situation, to realize control and. organization of an aid. for children from the foci of tuberculosis infection and. to carry out controlled chemical prophylaxis in sanatorium conditions
A RARE CASE OF MAXILLARY SINUS METASTASIS OF RENAL CELL CARCINOMA
The paper describes a rare case of maxillary sinus metastasis of renal cell carcinoma in a 50-year-old man 7 years after nephrectomy. The tumor appeared as bleeding leading to anemia. The diagnostic difficulties associated with differences in X-ray and biopsy morphological data are considered. A correct diagnosis could be established during planned histological examination of the removed tumor. Adjuvant immunotherapy was performed. Examination following 8 postoperative months revealed no signs of progressive disease. The authors give a literature review
IDENTIFICATION OF PERIODONTITIS PATHOGENIC MICROORGANISMS IN PATIENTS WITH THE DIAGNOSIS OF ESSENTIAL ARTERIAL HYPERTENSIA BY MEANS OF PCR METHOD
Periodontitis the same as brain, heart, kidneys is an organ-target for an arterial hypertensia. Disturbances in system of the microcirculatory bed, influencing a trophism of tissues of dentoalveolar system that promotes more active course of pathological processes in periodontitis thus develop. Actual revealing periodontitis pathogenic microorganisms in patients with an essential arterial hypertensia thereupon is represented. By us it is spent indication of five periodontitis pathogenic microorganisms, which most often causing development of diseases, in teenagers with an essential hypertensia by means of test system Β«Multident-5Β» (Β«GenlabΒ», Moscow)
Lynx1 and AΞ²1β42 bind competitively to multiple nicotinic acetylcholine receptor subtypes
AbstractLynx1 regulates synaptic plasticity in the brain by regulating nicotinic acetylcholine receptors (nAChRs). It is not known to which extent Lynx1 can bind to endogenous nAChR subunits in the brain or how this interaction is affected by Alzheimer's disease pathology. We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates Ξ±3, Ξ±4, Ξ±5, Ξ±6, Ξ±7, Ξ²2, and Ξ²4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain. Incubation with Ws-Lynx1 decreases nicotine-mediated extracellular signalβregulated kinase phosphorylation in PC12 cells and striatal neurons, indicating that binding of Ws-Lynx1 is sufficient to inhibit signaling downstream of nAChRs. The effect of nicotine in PC12 cells is independent of Ξ±7 or Ξ±4Ξ²2 nAChRs, suggesting that Lynx1 can affect the function of native non-Ξ±7, non-Ξ±4Ξ²2 nAChR subtypes. We further show that Lynx1 and oligomeric Ξ²-amyloid1β42 compete for binding to several nAChR subunits, that Ws-Lynx1 prevents Ξ²-amyloid1β42βinduced cytotoxicity in cortical neurons, and that cortical Lynx1 levels are decreased in a transgenic mouse model with concomitant Ξ²-amyloid and tau pathology. Our data suggest that Lynx1 binds to multiple nAChR subtypes in the brain and that this interaction might have functional and pathophysiological implications in relation to Alzheimer's disease
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