Youth entrepreneursh1p: definitions, challenges and prospects of development

The article deals with the definition of «youth entrepreneurship», age stages and psychological types of young entrepreneurs. The authors highlighted the barriers of youth entrepreneurs hip and ways of overcoming them.В статье рассматриваются определение понятия «молодежное предпринимательство», возрастные стадии и психологические типы молодых предпринимателей. Выделены барьеры предпринимательской деятельности молодежи и пути их преодоления

Supersymmetric vertex algebras

We define and study the structure of SUSY Lie conformal and vertex algebras. This leads to effective rules for computations with superfields.Comment: 71 page

Semirigid Geometry

We provide an intrinsic description of $N$-super \RS s and $TN$-\SR\ surfaces. Semirigid surfaces occur naturally in the description of topological gravity as well as topological supergravity. We show that such surfaces are obtained by an integrable reduction of the structure group of a complex supermanifold. We also discuss the \s moduli spaces of $TN$-\SR\ surfaces and their relation to the moduli spaces of $N$-\s\ \RS s.Comment: 29p

Exposure of vanadium as a factor of adverse activation of lymphocytes

We have estimated effect of vanadium influence on apoptosis of peripheral blood lymphocytes among workers. Immunologic assessment have allowed establishing that people working under the conditions of vanadium exposure have significantly increased quantity of annexin-positive cells indicating apoptosis in comparison with a reference group of people. We have identified statistically significant adverse mobilization of lymphocytes in respondents who have been working under conditions of the hazardous industry over 10 years. Therefore, the level and duration of the vanadium exposure influenced by the length of em plopent increase the immune system dysfunction degree.Проведена оценка влияния ванадия на клеточную гибель лимфоцитов периферической крови у работающих. Оценка иммунного статуса позволила установить, что у работающих в условиях экспозиции ванадием количество аннексин-позитивных клеток, свидетельствующих об апоптозе, достоверно повышается по отношению к группе сравнения. Выявлена статистически значимая негативная активация лимфоцитов у обследуемых, чей стаж в условиях вредного производства превышал 10 лет. Таким образом, уровень и длительность экспозиции ванадием, определяемая стажем работы, усугубляет степень дисфункции иммунной системы

Epidemiological situation on tuberculosis among the children and teenage population 159 (review of literature)

Tuberculosis is nowadays one of the most actual problems of world public health, service. According to the data of WHO, one third of world's population is infected, with tuberculosis microbacteria. Every year 2-3 millions of people die because of tuberculosis. During last years in Russia tuberculosis morbidity increased 2,3 times, mortality - 1,9 times and prevalence - 4 %. Aggravation of epidemiological situation on tuberculosis is characterized by increase of morbidity among all age groups and especially among the children. In Irkutsk region epidemiological situation on tuberculosis is still intensive. Main reasons of unsatisfactory indices of tuberculosis in Irkutsk region are: presence of significant reservoir of tuberculosis infection among the population. of the region; significant level of prevalence of HIV-infection; unsatisfactory material and technical base of antituberculous institutions of the region; personnel deficiency in antituberculous institutions; insufficient level of preventive measures in foci of tuberculosis infection; absence of modern, medical informational system in antituberculous institutions of the region. To optimize the situation at the development of antituberculous measures it is necessary to take into account regional peculiarities of epidemic situation, to realize control and. organization of an aid. for children from the foci of tuberculosis infection and. to carry out controlled chemical prophylaxis in sanatorium conditions

A RARE CASE OF MAXILLARY SINUS METASTASIS OF RENAL CELL CARCINOMA

The paper describes a rare case of maxillary sinus metastasis of renal cell carcinoma in a 50-year-old man 7 years after nephrectomy. The tumor appeared as bleeding leading to anemia. The diagnostic difficulties associated with differences in X-ray and biopsy morphological data are considered. A correct diagnosis could be established during planned histological examination of the removed tumor. Adjuvant immunotherapy was performed. Examination following 8 postoperative months revealed no signs of progressive disease. The authors give a literature review

IDENTIFICATION OF PERIODONTITIS PATHOGENIC MICROORGANISMS IN PATIENTS WITH THE DIAGNOSIS OF ESSENTIAL ARTERIAL HYPERTENSIA BY MEANS OF PCR METHOD

Periodontitis the same as brain, heart, kidneys is an organ-target for an arterial hypertensia. Disturbances in system of the microcirculatory bed, influencing a trophism of tissues of dentoalveolar system that promotes more active course of pathological processes in periodontitis thus develop. Actual revealing periodontitis pathogenic microorganisms in patients with an essential arterial hypertensia thereupon is represented. By us it is spent indication of five periodontitis pathogenic microorganisms, which most often causing development of diseases, in teenagers with an essential hypertensia by means of test system «Multident-5» («Genlab», Moscow)

Lynx1 and Aβ1–42 bind competitively to multiple nicotinic acetylcholine receptor subtypes

AbstractLynx1 regulates synaptic plasticity in the brain by regulating nicotinic acetylcholine receptors (nAChRs). It is not known to which extent Lynx1 can bind to endogenous nAChR subunits in the brain or how this interaction is affected by Alzheimer's disease pathology. We apply affinity purification to demonstrate that a water-soluble variant of human Lynx1 (Ws-Lynx1) isolates α3, α4, α5, α6, α7, β2, and β4 nAChR subunits from human and rat cortical extracts, and rat midbrain and olfactory bulb extracts, suggesting that Lynx1 forms complexes with multiple nAChR subtypes in the human and rodent brain. Incubation with Ws-Lynx1 decreases nicotine-mediated extracellular signal–regulated kinase phosphorylation in PC12 cells and striatal neurons, indicating that binding of Ws-Lynx1 is sufficient to inhibit signaling downstream of nAChRs. The effect of nicotine in PC12 cells is independent of α7 or α4β2 nAChRs, suggesting that Lynx1 can affect the function of native non-α7, non-α4β2 nAChR subtypes. We further show that Lynx1 and oligomeric β-amyloid1–42 compete for binding to several nAChR subunits, that Ws-Lynx1 prevents β-amyloid1–42–induced cytotoxicity in cortical neurons, and that cortical Lynx1 levels are decreased in a transgenic mouse model with concomitant β-amyloid and tau pathology. Our data suggest that Lynx1 binds to multiple nAChR subtypes in the brain and that this interaction might have functional and pathophysiological implications in relation to Alzheimer's disease