Comparison of the EMG Activities in the Vastus Medialis Oblique and Vastus Lateralis Muscles During Hip Adduction and Terminal Knee Extension Exercise Protocols

The purpose of this study was to compare the electromyographic (EMG) activities in the vastus medialis oblique (VMO) and vastus lateralis (VL) muscles during two open chain exercises commonly used in the management of patellofemoral pain syndrome (PFPS). Twenty-five (14 female and 11 male) healthy subjects participated in the study. The A 2 (testing condition) x 2 (exercise type) x 2 (gender) quasi-experimental design was employed. Using surface electrodes, the EMG activities in the VMO and the VL muscles during ten repetitions of hip adduction and terminal knee extension exercises were recorded. The order of presentation of the experimental conditions was randomized. The three-way repeated ANOVA revealed no significant main effects for testing conditions, exercise type or gender, but the terminal knee extension exercise type x gender interaction effect was statistically significant (F= 8.28,

Characterizing the weight-glycemia phenotypes of type 1 diabetes in youth and young adulthood

IntroductionIndividuals with type 1 diabetes (T1D) present with diverse body weight status and degrees of glycemic control, which may warrant different treatment approaches. We sought to identify subgroups sharing phenotypes based on both weight and glycemia and compare characteristics across subgroups.Research design and methodsParticipants with T1D in the SEARCH study cohort (n=1817, 6.0–30.4 years) were seen at a follow-up visit >5 years after diagnosis. Hierarchical agglomerative clustering was used to group participants based on five measures summarizing the joint distribution of body mass index z-score (BMIz) and hemoglobin A1c (HbA1c) which were estimated by reinforcement learning tree predictions from 28 covariates. Interpretation of cluster weight status and glycemic control was based on mean BMIz and HbA1c, respectively.ResultsThe sample was 49.5% female and 55.5% non-Hispanic white (NHW); mean±SD age=17.6±4.5 years, T1D duration=7.8±1.9 years, BMIz=0.61±0.94, and HbA1c=76±21 mmol/mol (9.1±1.9)%. Six weight-glycemia clusters were identified, including four normal weight, one overweight, and one subgroup with obesity. No cluster had a mean HbA1c <58 mmol/mol (7.5%). Cluster 1 (34.0%) was normal weight with the lowest HbA1c and comprised 85% NHW participants with the highest socioeconomic position, insulin pump use, dietary quality, and physical activity. Subgroups with very poor glycemic control (ie, ≥108 mmol/mol (≥12.0%); cluster 4, 4.4%, and cluster 5, 7.5%) and obesity (cluster 6, 15.4%) had a lower proportion of NHW youth, lower socioeconomic position, and reported decreased pump use and poorer health behaviors (overall p<0.01). The overweight subgroup with very poor glycemic control (cluster 5) showed the highest lipids and blood pressure (p<0.01).ConclusionsThere are distinct subgroups of youth and young adults with T1D that share weight-glycemia phenotypes. Subgroups may benefit from tailored interventions addressing differences in clinical care, health behaviors, and underlying health inequity