The Onset for Compressibility Effects for Aerofoils in Ground Effect

The influence of flow compressibility on a highly-cambered inverted aerofoil in ground effect is presented, based on two-dimensional computational studies. This type of problem has relevance to open-wheel racing cars, where local regions of high-speed subsonic flow form under favourable pressure gradients, even though the maximum freestream Mach number is typically considerably less than Mach 0.3. An important consideration for CFD users in the field is addressed in this paper, the freestream Mach number at which flow compressibility significantly affects aerodynamic performance. More broadly, for aerodynamicists, the consequences of this are also considered. Comparisons between incompressible and compressible CFD siulations are used to identify important changes to the flow characteristics caused by density changes, highlighting the inappropriateness of incompressible simulations of ground effect flows for freestream Mach numbers as low as 0.15

Deconvolution of conformational exchange from Raman spectra of aqueous RNA nucleosides

Ribonucleic acids (RNAs) are key to the central dogma of molecular biology. While Raman spectroscopy holds great potential for studying RNA conformational dynamics, current computational Raman prediction and assignment methods are limited in terms of system size and inclusion of conformational exchange. Here, a framework is presented that predicts Raman spectra using mixtures of sub-spectra corresponding to major conformers calculated using classical and ab initio molecular dynamics. Experimental optimization allowed purines and pyrimidines to be characterized as predominantly syn and anti, respectively, and ribose into exchange between equivalent south and north populations. These measurements are in excellent agreement with Raman spectroscopy of ribonucleosides, and previous experimental and computational results. This framework provides a measure of ribonucleoside solution populations and conformational exchange in RNA subunits. It complements other experimental techniques and could be extended to other molecules, such as proteins and carbohydrates, enabling biological insights and providing a new analytical tool

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Thermodynamics of peptide association and protein folding

SIGLEAvailable from British Library Document Supply Centre- DSC:D061976 / BLDSC - British Library Document Supply CentreGBUnited Kingdo