Two-qutrit Entanglement Witnesses and Gell-Mann Matrices

The Gell-Mann $\lambda$ matrices for Lie algebra su(3) are the natural basis for the Hilbert space of Hermitian operators acting on the states of a three-level system(qutrit). So the construction of EWs for two-qutrit states by using these matrices may be an interesting problem. In this paper, several two-qutrit EWs are constructed based on the Gell-Mann matrices by using the linear programming (LP) method exactly or approximately. The decomposability and non-decomposability of constructed EWs are also discussed and it is shown that the $\lambda$-diagonal EWs presented in this paper are all decomposable but there exist non-decomposable ones among $\lambda$-non-diagonal EWs.Comment: 25 page

Genetic contribution to radiographic severity in osteoarthritis of the knee

Objective Knee osteoarthritis (OA) has a significant genetic component. The authors have assessed the role of three variants reported to influence risk of knee OA with p<5×10–8 in determining patellofemoral and tibiofemoral Kellgren Lawrence (K/L) grade in knee OA cases. Methods 3474 knee OA cases with sky-line and weight-bearing antero-posterior x-rays of the knee were selected based on the presentation of K/L grade ≥2 at either the tibiofemoral or patellofemoral compartments for one or both knees. Patients belonging to three UK cohorts, were genotyped for rs143383, rs4730250 and rs11842874 mapping to the GDF5, COG5 and MCF2L genes, respectively. The association between tibiofemoral K/L grade and patellofemoral K/L grade was assessed after adjusting for age, gender and body mass index. Results No significant association was found between the rs4730250 and radiographic severity. The rs11842874 mapping to MCF2L was found to be nominally significantly associated with patellofemoral K/L grade as a quantitative trait (p=0.027) but not as a binary trait. The GDF5 single nucleotide polymorphism rs143383 was associated with tibiofemoral K/L grade (β=0.05 (95% CI 0.02 to 0.08) p=0.0011). Conclusions Our data indicate that within individuals affected by radiographic knee OA, OAGDF5 has a modest but significant effect on radiographic severity after adjustment for the major risk factors

Low Gain Avalanche Detectors (LGAD) for particle physics and synchrotron applications

A new avalanche silicon detector concept is introduced with a low gain in the region of ten, known as a Low Gain Avalanche Detector, LGAD. The detector's characteristics are simulated via a full process simulation to obtain the required doping profiles which demonstrate the desired operational characteristics of high breakdown voltage (500 V) and a gain of 10 at 200 V reverse bias for X-ray detection. The first low gain avalanche detectors fabricated by Micron Semiconductor Ltd are presented. The doping profiles of the multiplication junctions were measured with SIMS and reproduced by simulating the full fabrication process which enabled further development of the manufacturing process. The detectors are 300 μm thick p-type silicon with a resistivity of 8.5 kΩcm, which fully depletes at 116 V. The current characteristics are presented and demonstrate breakdown voltages in excess of 500 V and a current density of 40 to 100 nAcm−2 before breakdown measured at 20oC. The gain of the LGAD has been measured with a red laser (660 nm) and shown to be between 9 and 12 for an external bias voltage range from 150 V to 300 V

Rigorous Multicomponent Reactive Separations Modelling : Complete Consideration of Reaction-Diffusion Phenomena

This paper gives the first step of the development of a rigorous multicomponent reactive separation model. Such a model is highly essential to further the optimization of acid gases removal plants (CO2 capture, gas treating, etc.) in terms of size and energy consumption, since chemical solvents are conventionally used.Firstly, two main modelling approaches are presented: the equilibrium-based and the rate-based approaches. Secondly, an extended rate-based model with rigorous modelling methodology for diffusion-reaction phenomena is proposed. The film theory and the generalized Maxwell-Stefan equations are used in order to characterize multicomponent interactions. The complete chain of chemical reactions is taken into account. The reactions can be kinetically controlled or at chemical equilibrium, and they are considered for both liquid film and liquid bulk. Thirdly, the method of numerical resolution is described. Coupling the generalized Maxwell-Stefan equations with chemical equilibrium equations leads to a highly non-linear Differential-Algebraic Equations system known as DAE index 3. The set of equations is discretized with finite-differences as its integration by Gear method is complex. The resulting algebraic system is resolved by the Newton- Raphson method. Finally, the present model and the associated methods of numerical resolution are validated for the example of esterification of methanol. This archetype non-electrolytic system permits an interesting analysis of reaction impact on mass transfer, especially near the phase interface. The numerical resolution of the model by Newton-Raphson method gives good results in terms of calculation time and convergence. The simulations show that the impact of reactions at chemical equilibrium and that of kinetically controlled reactions with high kinetics on mass transfer is relatively similar. Moreover, the Fick’s law is less adapted for multicomponent mixtures where some abnormalities such as counter-diffusion take place

General Practitioner Autism Training and Mandatory Medical Training: A Cross-Sectional Study of GPs’ Knowledge, Attitudes and Practices

Numerous physical conditions appear with increased frequency in autistic individuals in comparison to their non-autistic peers. These co-existing conditions are known to lead to higher morbidity, lower quality of life, and lower life expectancy in autisticadults. There is substantial evidence in the literature that many, if not most, General Practitioners (GPs) in the United Kingdom do not have the necessary understanding of autism to enable them to offer the same standard of service to their autistic patients that their non-autistic patients receive. This research project was set up, inter alia, to explore the attitudes of GPs to the introduction of autism training and the contentious issue of making GP training on any subject mandatory rather than voluntary. We wanted to better understand how autism training for GPs might be developed to maximise "take-up" and “buy-in” given that the demands on their time, including training demands, are such that autism is only one of many conditions vying for training time and mandatory training is anathema to many GPs. Key findings were that nearly three quarters of our respondents strongly agreed that training in autism is important for GPs, the same percentage of our participants had received little or no formal autismtraining, and there was a general dislike of any training being made mandatory. Training should be focused on barriers faced by autistic people in accessing healthcare as well as on autism as a medical condition. No respondent had received a significant level of training in autism although 40% of participants who had received training had been trained by an autistic individual

Ending preventable child deaths in South Africa: What role can ward-based outreach teams play?

South Africa (SA) has emerged from the Millennium Development Goal era with a  mixture of success and failure. The successful national scale-up of prevention of  mother-to-child transmission of HIV services with increasingly efficacious   antiretroviral regimens has reduced the mother-to-child transmission rate dramatically; however, over the same period there appears to have been no progress in coverage of high-impact interventions for pneumonia and diarrhoea, which are now leading causes of under-5 mortality. SA embarked on a strategy to re-engineer the primary healthcare system in 2011, which included the creation of ward-based outreach teams consisting of community health workers (CHWs). In this article we argue that the proposed ratio of CHWs to population is too low for public health impact and that the role and scope of CHWs should be extended beyond giving of health information to include assessment and treatment of childhood illnesses (particularly diarrhoea and suspected pneumonia). Evidence and experience amply demonstrate that CHWs in sufficient density can have a rapid and positive impact on neonatal and young child mortality, especially when they are allowed to treat common acute conditions. SA’s mediocre performance in child survival could be dramatically improved if there were more CHWs who were allowed to do more