Gastrointestinal stromal tumors: A multicenter study of 1160 Turkish cases

Background/aims: The aim of this multicenter study was to determine the histopathological features and immunohistochemical profiles of gastrointestinal stromal tumors diagnosed in Turkish patients. Material and Methods: Twenty-eight participating centers registered their gastrointestinal stromal tumor cases on a nationwide database. The diagnosis of gastrointestinal stromal tumor relied upon hematoxylin & eosin features and the results of antibody panel including CD117, CD34, desmin, smooth muscle actin, S-100 protein, and Ki67. The database consisted of parameters including age, gender, location, and all other histopathological and immunohistochemical findings. Statistical analysis was performed using Pearson, Kruskal-Wallis, Mann-Whitney U, and Spearman tests. Results: From all of the gastrointestinal stromal tumors in the database, 1160 cases with a male to female ratio of 1.22 and a mean age of 56.75 years were included in the study. The most common location was the stomach (45.0%), followed by the small intestine, omentum-peritoneum, large intestine, and esophagus (32.0%, 12.6%, 9.3%, 1.1%, respectively). The risk groups were distributed as: 6.1% very low, 21.7% low, 19.3% intermediate, and 53% high-risk cases. Many histopathologic findings were correlated with risk groups. CD117 was positive in 95.3% of gastrointestinal stromal tumors, whereas CD34 was positive in 74.9%, smooth muscle actin in 45.9%, desmin in 9.2%, and S-100 in 19.1.%. Though no significant relation was found between CD117 expression and tumor location, CD34, smooth muscle actin and Ki67 expressions significantly varied in different locations (p=0.001) and risk groups. Conclusions: The results of this multicenter study demonstrated that features other than tumor size and mitosis and immune markers other than CD117 and Ki67 included in the antibody panel seem to be useful as predictive risk factors

Primary umbilical adenocarcinoma: Case report and review of the literature

Primary adenocarcinoma arising at the umbilicus is a very rare condition. The umbilicus has been found to show a wide variety of tumors and is predisposed to metastases from visceral tumors because of its relationships and generous vascular and embryologic connections. Herein, we describe a case of a primary umbilical adenocarcinoma with short time survival related to local recurrence and multiple hepatic metastases 6 months after her surgical treatment

Characterization of frequency-dependent material properties of human liver and its pathologies using an impact hammer

The current methods for characterization of frequency-dependent material properties of human liver are very limited. In fact, there is almost no data available in the literature showing the variation in dynamic elastic modulus of healthy or diseased human liver as a function of excitation frequency. We show that frequency-dependent dynamic material properties of a whole human liver can be easily and efficiently characterized by an impact hammer. The procedure only involves a light impact force applied to the tested liver by a hand-held hammer. The results of our experiments conducted with 15 human livers harvested from the patients having some form of liver disease show that the proposed approach can successfully differentiate the level of fibrosis in human liver. We found that the storage moduli of the livers having no fibrosis (F0) and that of the cirrhotic livers (F4) varied from 10 to 20 kPa and 20 to 50 kPa for the frequency range of 0-80 Hz, respectively. (C) 2010 Elsevier B.V. All rights reserved

MIXED HCC-CHOLANGIOCARCINOMA AND INTRAHEPATIC CHOLANGIOCARCINOMA IN PATIENTS UNDERGOING LIVER TRANSPLANTATION FOR HCC

WOS: 000411688503074

Xanthogranulomatous sialadenitis clinically mimicking a malignancy: case report and review of the literature

Background Xanthogranulomatous tissue reaction is a welldocumented process that is most common in kidney. There are other uncommon sites being documented as case reports in the literature. We would like to describe the clinicopathologic findings in a case of xanthogranulomatous sialadenitis that involved the parotid gland, which was clinically thought to be a tumoral mass, and compare it with the 4 previously reported cases

Gastroenteropancreatic neuroendocrine tumors: 10-year experience in a single center

Neuroendocrine tumors originate from neuroendocrine cells and occur in a wide spectrum from carcinoid tumors to small cell carcinomas. Although the World Health Organization determined clinical and histological features to predict prognosis for such tumors, they may not be valid on an individual basis. This study investigates the clinical, pathologic and prognostic characteristics of gastroenteropancreatic neuroendocrine tumors that presented to the Medical Oncology Outpatient Clinic, A degrees stanbul University, CerrahpaAYa School of Medicine from 1995 to 2006 (n = 86). The mean age of the patients was 52 +/- A 14 and the male-to-female ratio was 0.87. The most common site of involvement was the stomach. Midgut intestinal tumors seemed to have significant female predominance compared to hindgut intestinal tumors (P = 0.016). Most of the patients had metastatic disease with a prevalence of 34.9%. Poorly differentiated tumors and mixed neuroendocrine carcinomas were significantly larger than 2 cm (P = 0.0001). The median survival was 139 months and the highest mortality was for colorectal tumors (36%). While univariate analysis revealed that the number of lymph nodes (P = 0.008), multiple foci (P = 0.034), metastases (P = 0.022) and stage (P = 0.034) correlated significantly with survival, there was no independent variable in the multivariate analysis. Hindgut tumors had significantly more Ki-67, mitosis and necrosis compared to others (P a parts per thousand currency sign 0.05). In this retrospective study, the clinical, pathologic and prognostic characteristics of gastroenteropancreatic tumors from a single center from Turkey were analyzed and compared with the current medical literature

Histological features in abdominal wall endometriosis

Endometriosis is localization of endometrial tissue out of endometrium and myometrium. Location on peritoneum and scar tissue associated with abdominal incision called as abdominal wall endometriosis (AWE). Abdominal wall endometriosis is a rare lesion affection under 1% of effected patients. However, due to increase in laparoscopy, hysterectomy and cesarean section procedurs, the AWE cases are increasing. In this study we aim to analyse AWE rates and evaluate their histologic properties. Endometriosis cases between 2010-2015 were included in study. These cases were evaluated according to localization and out of these 23 cases were revealed as AWE, and in 15 of 23 cases histologic specimens can reach. 317 cases with endometriosis were revealed and 23 (7.2%) were identified as AWE. The mean age was 35±5 (29-45). In 11 (47.8%) cases AWE was developed on scar tissue which have a history of cesarean section procedurs in a mean 3.4 year before. In 10 (66%) cases tubal (ciliary) metaplasia, in 3 (20%) cases hobnail metaplasia and in one case (7%) atypia and mitosis were observed as glandular changes. In 11 (73%) cases myxoid changes, 3 (20%) signet ring-like cells-like changes, 2 (13%) atypical myocytes with giant cells, in one (7%) case thick walled vessels resemble spiral arteries of endometrium and in one case (7%) decidual changes were observed as stromal changes. In this study we highlight the high prevalence of AWE compare to literature. Besides, the wide spectrum of stromal and glandular metaplastic changes could be challenging in proper diagnosis. AWE should keep in mind in the differential diagnosis of lesions in this localization. [Med-Science 2018; 7(2.000): 398-401