Comparison of the differences in circadian autonomic function in hyperlipidemic men with and without erectile dysfunction

WOS: 000284910500007PubMed: 19866371Background We aimed to investigate differences in circadian autonomic changes in patients suffering from hyperlipidemia with and without erectile dysfunction and compared results to control cases. Materials and methods A total of 77 patients (age range: 24-74, mean age: 45.3 +/- 9.3) with uncontrolled hyperlipidemia (total cholesterol > 200 mg/dL and/or LDL > 160 mg/dL despite a regular diet) were enrolled into the study. These patients were divided into two groups according to their International Index of Erectile Function (IIEF-EF) scores as having erectile dysfunction (IIEF-EF = 26) (Group 2). In addition, the control group comprised 44 healthy men (age range: 20-57, mean age: 44.0 +/- 10.8) (Group 3). Heart rate variability parameters obtained by 24-h Holter monitoring were utilized for the indirect evaluation of autonomic function. Results There were statistically significant differences between the groups with respect to daytime and nocturnal autonomic activity (p 0.05; for nocturnal LFn p(1-2) 0.05). Conclusion We concluded that hyperlipidemia results in deterioration of autonomic circadian rhythm. Hyperlipidemic patients with erectile dysfunction had diminished nocturnal parasympathetic activities

The Difference of Heart Rate Recovery between Males with and without Erectile Dysfunction

WOS: 000279897800005PubMed: 20645964Material and Methods: A total of 135 participants (mean age: 45.0 +/- 11.8 years) were enrolled into the study. Detailed biochemical and hormonal analyses, 12-lead electrocardiography and EST (Treadmill) were performed in all participants. Erectile function was assessed using the International Index of Erectile Function (IIEF) questionnaire form. Patients were categorized into two groups according to their IIEF scores as ED (+) (IIEF = 26). Afterward, statistical analyses were performed to evaluate the correlations between ED and HRR and CHIND. Results: A total of 65 patients were ED (+) (mean age 44.9 +/- 6.4 years), while 70 patients (mean age 43.7 +/- 7.7 years) had normal erectile status. There were statistically significant differences in CHIND (P = 0.015) and HRR time (P = 0.037) between ED (+) and ED (-) patients. In correlation analysis, IIEF score was found positively correlated with HRR and metabolic equivalent (MET) values (r(HRR) = 0.293, P = 0.037; r(METs) = 0.388, P = 0.011, respectively). Linear regression analysis revealed that METs value and total exercise time had a more linear relationship with IIEF score compared to the other EST parameters (p(METs) = 0.002 and p(TET) = 0.015, respectively). Conclusion: Chronotropic incompetence and dynamic postexercise autonomic dysfunction are present in ED patients. This condition may reflect decreased functional capacity and exercise intolerance in these patients. Ann Noninvasive Electrocardiol 2010;15(3):223-229

The changing face of angiographic patterns of restenosis after drug-eluting stent placement: Sirolimus versus paclitaxel-eluting stent

Celik, Turgay/0000-0001-8418-0130WOS: 000260112800016PubMed: 17673319

Coronary stent strut fracture after drug-eluting stent implantation: A newly recognized complication

Celik, Turgay/0000-0001-8418-0130WOS: 000262978900017PubMed: 17692950Stent strut fracture (SSF) after drug-eluting stent (DES) implantation may be an important complication after DES implantation particularly in patients undergoing sirolimus eluting stent implantation. Since SSF is a highly relevant adverse event which can result in in-stent restenosis and thrombosis, we belive that DES with flexible stent platform or biodegradable DES may be needed to prevent this potential catastrophic complication. (C) 2007 Elsevier Ireland Ltd. All rights reserved

Statin use in chronic heart failure: Waiting for the results of large prospective outcome trials

Celik, Turgay/0000-0001-8418-0130WOS: 000262978900018PubMed: 17765985

Impact of metabolic syndrome on left ventricular mass: Is the same in all ethnic groups and in men and women?

Celik, Turgay/0000-0001-8418-0130WOS: 000262328700015PubMed: 17689759

Uncomplicated retainment of metal coronary bulldog clips recognized five years after coronary artery bypass graft surgery

WOS: 000293479500022We report a patient with retained metal coronary bulldog clips in the mediastinum during coronary artery bypass surgery which was recognized during coronary angiography following the diagnosis of unstable angina pectoris after an uncomplicated period of five years. This case suggests that conservative management of patients with postoperatively recognized retained foreign material should be kept in mind as an alternative to reoperation

Transposition of the great arteries in a newborn whose mother was treated with carbamazepine during pregnancy

WOS: 000254244100044PubMed: 17785243

A case of Guillain-Barre syndrome following prosthetic valve endocarditis

Celik, Turgay/0000-0001-8418-0130; Bek, Semai/0000-0003-4913-976XWOS: 000263950100017PubMed: 17942174Guillain-Barre syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy associated with progressive limb weakness and areflexia. Up to now, a few cases of GBS following infective endocarditis (IE), particularly prosthetic valve endocarditis, have been reported. We present a case of a 63-year-old male patient in whom GBS developed following aortic prosthetic valve endocarditis. Although GBS is not frequently encountered in patients with IE, we believe that every clinician should consider the probable GBS in those patients suffering from distal paresthesis, progressive limb weakness and ataxia. (C) 2007 Elsevier Ireland Ltd. All rights reserved

Effects of statin treatment on serum sex steroids levels and autonomic and erectile function

Batislam, Ertan/0000-0002-7493-4573WOS: 000254813800038PubMed: 18387399OBJECTIVES To investigate the effect of statin treatment on serum sex steroid levels, heart rate variability, erectile function, and libido in patients with hyperlipidemia. METHODS A total of 74 patients (mean age 44.7 +/- 7.1 years) with hyperlipidemia were enrolled into this study. After a cardiac examination, the serum lipid levels were measured, and the 24-hour Holter monitoring, heart rate variability, and autonomic test results were also evaluated. Erectile function was assessed using the International Index of Erectile Function (IIEF) questionnaire. Later, atorvastatin 40 mg/day was initiated in all patients and used for the subsequent 12 months. All diagnostic tests (cardiac, biochemical, and autonomic and the IIEF questionnaire) were performed again at 6 and 12 months of follow-Lip. RESULTS A statistically significant decrease was found in the serum lipid levels at 6 months (P0.05). In paired comparison, significant differences were found among the IIEF scores of the three periods (P = 0.013). The difference was more evident after 6 months of treatment (IIEF1vs2 = 0.475; IIEF1vs3 = 0.027; IIEF2vs3 = 0.012). CONCLUSIONS Although improvement in the lipid profile occurred early during the statin treatment, restoration of erectile function appeared later, which Could be attributed to the restoration of endothelial functions by lowered serum lipid levels