Solitary Amyloid Tumor of the Tongue Base

The purpose of this article is to present a rare case of localized, solitary amyloid tumor of tongue base and emphasize some of the characteristic features of challenging clinical and histopathologic diagnosis. In this paper, we focused on the clinical and pathological specifications of this rare tumor, so any unnecessary examinations or measures may be spared. Negative staining of amyloid material with AAC and osseous metaplasia noted in the histopathologic examination may not be thought as definite criteria for localized amyloidosis, but a supporter of localized, solitary amyloid tumor diagnosis

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Oxalosis, deposition of calcium oxalate in tissues, is the final stage of hyperoxaluric syndromes. Being a rare entity, it is often missed, or the diagnosis is delayed, since the definitive diagnosis requires special laboratory tests. Kidneys, the walls of blood vessels, and bones are the major sites for crystal deposition. We report the autopsy findings of a 4-year-old girl who presented with end-stage renal disease in which the clinical presentation was consistent with primary hyperoxaluria Type 1. The case is unusual, as there was extensive crystal deposition throughout the body, including in tissues that are rarely involved, such as ovaries, fallopian tubes, uterus, thymus, salivary glands, pancreas, and bladder

Rare but intriguing lesions of gastrointestinal tract: Parasitic infestations

WOS: 00034438680111

Feasibility and clinical utility of intraoperative consultation with frozen section in osseous lesions

PubMed ID: 22772767Intraoperative consultation (IOC) with frozen section (FS) allows the surgeon to make therapy decisions during the operation.However, there is relatively little information on the use of IOC in skeletal lesions. We performed a retrospective study to examine the indications for IOC and compare the histological findings of FS and permanent paraffin section (PS) results to determine its clinical benefits. Ninety-seven consecutive cases evaluated between 2008 and 2011 were retrieved from IOC archives of our Pathology Department. In 79 % of the cases, there was no prior core needle biopsy (CNB), and IOC was performed to confirm the clinical or radiological diagnosis. In 5 (5 %) cases, no definitive result could be obtained with FS, and diagnosis was deferred. The reasons for a deferred diagnosis (DD) included poor section quality in two lipomatous lesions and the sample heterogeneity in the others. When adjusted for DD, FS and PS results showed 100 % concordance in terms of discriminating "benign vs. malignant" and defining diagnostic categories as "benign non-tumoral," "benign tumoral/tumor-like, " "malignant primary tumor," "malignant metastatic tumor," or "hematopoietic malignancy." The presence of non-sclerotic osseous tissues does not have a significant adverse impact on the FS section quality and diagnosis made by FS. Thus, sections with diagnostic value can be obtained from bone lesions via FS. In this study, specific diagnoses were made in 88 % of the cases. We believe that IOC with FS can be safely performed in tertiary referral centers where there is a multidisciplinary team working in collaboration. © Springer-Verlag 2012

A mixed neuroendocrine tumor loceted in appendix vermiformis: "Goblet cell carsinoid''

WOS: 00031036480154

Streptozotocin-induced diabetic effects on spermatogenesis with proliferative cell nuclear antigen immunostaining of adult rat testis

WOS: 000185603100021PubMed ID: 14505760Objective: To examine the histopathological effects of diabetes on spermatogenesis and to detect the proliferation of germ cells with proliferative cell nuclear antigen (PCNA). Design: Controlled experimental study. Setting: The animal laboratory of the Experimental Surgery Center of Ege University, Izmir, Turkey. Animal(s): Ten nondiabetic (control) and 20 diabetic adult male albino rats. Intervention(s): The rats were IP injected with 40 mg/kg streptozotocin for 5 days to create a diabetic condition that was confirmed by testing blood glucose levels 5-7 days after the first injection. Main Outcome Measure(s): Mean testicular diameter, mean semniferous tubuli diameter (MSTD), and PCNA index. Result(s): Six weeks after the streptozotocin injection, both the mean testicular and the semniferous tubuli diameters were significantly decreased in diabetic rats compared with the control group. Conclusion(s): The effects of diabetes on spermatogenesis can be clearly detected as a decrease in testicular diameter, MSTD, and PCNA index. (C) 2003 by American Society for Reproductive Medicine