8 research outputs found
The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2006
- Field of study
BACKGROUND: The Tissue Microarray (TMA) facilitates high-throughput analysis of hundreds of tissue specimens simultaneously. However, bottlenecks in the storage and manipulation of the data generated from TMA reviews have become apparent. A number of software applications have been developed to assist in image and data management; however no solution currently facilitates the easy online review, scoring and subsequent storage of images and data associated with TMA experimentation. RESULTS: This paper describes the design, development and validation of the Virtual Tissue Matrix (VTM). Through an intuitive HTML driven user interface, the VTM provides digital/virtual slide based images of each TMA core and a means to record observations on each TMA spot. Data generated from a TMA review is stored in an associated relational database, which facilitates the use of flexible scoring forms. The system allows multiple users to record their interpretation of each TMA spot for any parameters assessed. Images generated for the VTM were captured using a standard background lighting intensity and corrective algorithms were applied to each image to eliminate any background lighting hue inconsistencies or vignetting. Validation of the VTM involved examination of inter-and intra-observer variability between microscope and digital TMA reviews. Six bladder TMAs were immunohistochemically stained for E-Cadherin, β-Catenin and PhosphoMet and were assessed by two reviewers for the amount of core and tumour present, the amount and intensity of membrane, cytoplasmic and nuclear staining. CONCLUSION: Results show that digital VTM images are representative of the original tissue viewed with a microscope. There were equivalent levels of inter-and intra-observer agreement for five out of the eight parameters assessed. Results also suggest that digital reviews may correct potential problems experienced when reviewing TMAs using a microscope, for example, removal of background lighting variance and tint, and potential disorientation of the reviewer, which may have resulted in the discrepancies evident in the remaining three parameters
An Objective Method for the Assessment of Psychosocial Problems in Adolescents with Epilepsy
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Mood, Personality, and Health-related Quality of Life in Epileptic and Psychogenic Seizure Disorders
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Presurgery Expectations, Postsurgery Satisfaction, and Psychosocial Adjustment After Epilepsy Surgery
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
MMPI-2 profiles: Fibromyalgia Patients Compared to Epileptic and Non-Epileptic Seizure Patients
- Author
- Amy L. Johnson
- André Barkhuizen
- Bennett RM
- Binder LM
- Binder LM
- Blasco CL
- Boscarino JA
- Butcher JN
- Butcher JN
- Campbell KA
- Daniel Storzbach
- Diane S. Rohlman
- Dodrill CB
- Fiedler N
- Gerson A
- Graham JR
- Greiffenstein MF
- Kaplan RF
- Landro NI
- Larrabee GJ
- Larrabee GJ
- Laurence M. Binder
- Martin C. Salinsky
- Merskey H
- Okifuji A
- Quesney LF
- Saw-Myo Tun
- Smythe H
- Storzbach D
- Vidal-Zas AR
- W. Kent Anger
- Walker EA
- Walker EA
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
The Potential for Vigabatrin-Induced Intramyelinic Edema in Humans
- Author
- Arezzo JC
- Ben-Menachem E
- Ben-Menachem E
- Blackwell N
- Browne TR
- Browne TR
- Browne TR
- Bryant AE
- Butler WH
- Butler WH
- Cannon DJ
- Cannon DJ
- Cosi V
- Cosi V
- Cosi V
- Dodrill CB
- Dodrill CB
- Dorman DC
- Duncan JS
- Elke T
- Fowler L.
- French JA
- Gibson JP
- Graham D.
- Grunewald RA
- Grunewald RA
- Guberman A
- Hammond EJ
- Hammond EJ
- Harding GF
- Hauw J-J
- Hauw JJ
- Hershey BL
- Jackson GD
- Jung MJ
- Jung MJ
- Kalviainen R
- Kalviainen R
- Krauss GL
- Liegeois-Chauvel C
- Loiseau P
- Mauguiere F
- McGuire AM
- Mervaala E
- Monaco F.
- Mumford JP
- Mumford JP
- O'Shaughnessy DJ
- Palfreyman MG
- Paljarvi L
- Peyster RG
- Reynolds EH
- Schroeder CE
- Srinivasan J
- Tartara A
- Tassinari CA
- Tripier MF
- Weiss KL
- Wilson EA
- Wong IC
- Yarrington JT
- Ylinen A
- Ylinen A
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies
- Author
- Aaron James Holland
- Abdullah Jumana T.
- Abrams Jonathan M.
- Abrashoff Riley
- Acevedo Andres B.
- Acha Iker
- Acosta Daniela M. Meza
- Adam Megan M.
- Adams Dante Q.
- Adams Elena R
- Adams Kalvyn N
- Akbar Zainab A.
- Akruwala Ushmi H.
- Al-Ghazwi Adel
- AlAbbas Batool H.
- Alahmed Mohammed S.
- AlAwadhi Areej A.
- Albakr Mohammed A.
- Albalushi Yusef J.
- Albaum Jonathan
- Aldhamen Ahmed
- Ales Nolan
- Alesmail Mohammad
- Alhabeeb Abdulelah
- Alhamli Dania
- AlHarbi Yazeed A.
- Alhuseini Isehaq
- Alkaabi Suhail
- Alkhezzi Tameem
- Alkubaisi Mohamed
- Allanqawi Nasser
- Allsbrook Martin
- Almohsen Yousef A.
- Almquist Justin Thomas
- Alnaji Teeb
- Alnasrallah Yousef A
- Alonzi Nicholas
- Alosaimi Meshal
- Alqabani Emeen
- Alrubaie Mohammad
- Alsinan Reema A.
- Altenbern Ava L.
- Altokhais Abdullah
- Alyami Saleh A.
- Ameijenda Federico
- Amer Hamzi
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- Anderson Hunter J.
- Andrew Carter
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- Angwin Abigail
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- Suri Rohan
- Swartz Jason R.
- Sweeney Joshua D.
- Syed Konner
- Szabo Emi
- Szeremeta Philip
- Ta Michael-Tan D.
- Tanguma Nolan C.
- Taulman Kyle
- Taylor Eleanor
- Taylor Liam C.
- Taylor Nicole
- Tayman K. E.
- Tellez Yesica
- Terrile Richard
- Tesdahl Corey D
- Thielmann Quinn N.
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- Thomas Jeffrey J.
- Thompson William N.
- Thornally Noah R.
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- Ton Kelly
- Toon Nathaniel J.
- Toups Malena C.
- Tran Bryn
- Tran Kevin
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- Trautwein Emily D.
- Traxler Robert B.
- Tressler Judah
- Trofino Tyson R.
- Troisi Thomas
- Trunko Benjamin L.
- Truong Joshua K.
- Tucker Julia
- Umbricht Thomas D
- Uphoff C. H.
- Upthegrove Zachary T.
- Vadayar Shreenija
- Valencia Whitney
- Vallery Mia M.
- Van Anne Gabreece
- VanEtten Eleanor
- Vann John D.
- Varela Ilian
- Vassilyev Alexandr
- Vaver Nicholas J.
- Velamala Anjali A.
- Vendetti Evan
- Venegas Nancy Ortiz
- Vepa Aditya V.
- Vess Marcus T.
- Veta Jenna S.
- Victory Andrew
- Vinson Jessica
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- Vogel Connor Maklain
- von Peccoz Charles B. Beck
- Von Reich Ferin J.
- Wagoner Michaela
- Wallace Logan
- Wallace Steven P.
- Waller Caroline
- Wang Chaoran
- Wang Hongda
- Wang Jiawei
- Warble Keenan
- Ward-Chene N. R. D.
- Watson James Adam
- Weber Robert J.
- Wegner Aidan B.
- Weigand Anthony A
- Weiner Amanda M.
- Werth Alexandra
- West Ayana
- West Colin G.
- Wexler Ethan Benjamin
- Wheeler Nicola H.
- White Jamison R.
- White Oliver S.
- White Zachary
- Whittall Lloyd C.
- Wickenden Evan
- Wilcove Isaac
- Wilkinson Blake C.
- Willard John S.
- Williams Abigail K.
- Williams Sajan
- Wilson Connor B.
- Wilson Evan M.
- Wilson John
- Wilson Orion K.
- Wilson Timothy R.
- Witkoff Briahn
- Wolfe Aubrey M.
- Wolle Jackson R.
- Wood Travis M.
- Woodard Aiden L.
- Woodraska Donald L.
- Wootten Katelynn
- Wu Mengyu
- Xiao Catherine
- Yang Jianing
- Yang Zhanchao
- Yegovtsev Nikolay
- Young Isabel
- Young Trenton J.
- Youngblood Allison A.
- Zenner Thomas
- Zhang Jiaqi
- zhang Jinhua
- Zhao Noah Y.
- Zhao Tiannie
- Zhao Tianwei
- Zhou Chongrui
- Ziebold Josh J
- Ziegler Lucas J.
- Zimmermann Ingrid H
- Zygmunt James C.
- Publication venue
- 'American Astronomical Society'
- Publication date
- 09/05/2023
- Field of study
Flare frequency distributions represent a key approach to addressing one of
the largest problems in solar and stellar physics: determining the mechanism
that counter-intuitively heats coronae to temperatures that are orders of
magnitude hotter than the corresponding photospheres. It is widely accepted
that the magnetic field is responsible for the heating, but there are two
competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To
date, neither can be directly observed. Nanoflares are, by definition,
extremely small, but their aggregate energy release could represent a
substantial heating mechanism, presuming they are sufficiently abundant. One
way to test this presumption is via the flare frequency distribution, which
describes how often flares of various energies occur. If the slope of the power
law fitting the flare frequency distribution is above a critical threshold,
α=2 as established in prior literature, then there should be a
sufficient abundance of nanoflares to explain coronal heating. We performed
>600 case studies of solar flares, made possible by an unprecedented number
of data analysts via three semesters of an undergraduate physics laboratory
course. This allowed us to include two crucial, but nontrivial, analysis
methods: pre-flare baseline subtraction and computation of the flare energy,
which requires determining flare start and stop times. We aggregated the
results of these analyses into a statistical study to determine that α=1.63±0.03. This is below the critical threshold, suggesting that Alfv\'en
waves are an important driver of coronal heating.Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The
Astrophysical Journal on 2023-05-09, volume 948, page 7
Angeborene Herz- und Gefäßfehler
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- JF Goodwin
- JF Goodwin
- JF Griffin
- JF Holt
- JF Meckel
- JFA McManus
- JG Claypool
- JG Mönckeberg
- JG Mönckeberg
- JG Mönckeberg
- JG Mönckeberg
- JG Videla
- JH Baylis
- JH Coffey
- JH Dadds
- JH Kneidel
- JH Semans
- JH Wright
- JJ Burroughs
- JJ Conn
- JJ Conn
- JJ Denie
- JJ Fahey
- JJ Garamella
- JJ Grossman
- JJ Kelly
- JJ Welti
- JJ Welti
- JL Braudo
- JL Braudo
- JL Buttin
- JL Calvin
- JL Emery
- JL Gonzalez-Cerna
- JL Pinninger
- JL Wright
- JM Douglas
- JM George
- JM Nelly
- JM Pattinson
- JN Dubin
- JN Dubin
- JN Pattinson
- JR Belcher
- JR Myhre
- JR Norcross
- JR Tobin
- JS Conant
- JS Hanson
- JS McKim
- JT Prior
- JV Boros
- JW Brown
- JW Brown
- JW Brown
- JW Brown
- JW Dow
- JW Dow
- JW Duckworth
- JW Dushane
- JW Dushane
- JW Dushane
- JW Kirklin
- JW Kirklin
- JW Kirklin
- JW Kirklin
- JW Kirklin
- JW Monie
- JWD Bull
- K Amplatz
- K Braun
- K Einhauser
- K Gefferth
- K Greineder
- K Greiner
- K Gutzeit
- K Gutzeit
- K Hart
- K Heckmann
- K Holldack
- K Jaffe
- K Klinke
- K Kremer
- K Liavaag
- K Mardersteig
- K Musshoff
- K Musshoff
- K Sternberg
- K Walton
- K Wolke
- KD Keele
- KFV Rokitansky
- KG Roschdestwensky
- KH Bauer
- Kirby
- KJ Welch
- KJ Welch
- KJ Welch
- KL Goerttler
- KL Goerttler
- KN Ordway
- KO Husebye
- KP Sinha
- KP Sinha
- KR Doraiswami
- KS Rosedale
- KS Smith
- KT Danneel
- L Arendt
- L Aschoff
- L Bard
- L Bretmacher
- L Brunetti
- L Dexter
- L Dexter
- L Dexter
- L Dexter
- L Feldman
- L Fishman
- L Gallavardin
- L Gerard
- L Gore
- L Gräper
- L Guglielmo Di
- L Guillamet
- L Hektoen
- L Hsu
- L Kern
- L Kucsko
- L Langerhan
- L Langeron
- L Mathey
- L Parkinson
- L Perlman
- L Roncoroni
- L Steinberg
- L Steinhart
- L Steinhart
- LA Campeau
- LA Eigen
- LA Erf
- LA Schall
- LA Soloff
- Langer
- Laurens
- LB Bosher Jr.
- LE Etter
- LG Druepple
- LG Rigler
- LH Garland
- LH Kettler
- LH Meeker
- LJ Boyd
- LJ Boyd
- LJ Manhoff Jr.
- LJ Ross
- LM Becu
- LM Becu
- LM Becu
- LM Blackford
- LM Blackford
- LM Bonnet
- LM Linde
- LP Elliott
- LR Limon
- LS Blumenthal
- LS Gordon
- LT Bullock
- LT Wald Le
- M Abbott
- M Anderson
- M Borst
- M Brombart
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Campbell
- M Cleveland
- M Cohen
- M Dahm
- M Dubois
- M Durand
- M Durand
- M Durand
- M Fogal
- M Franke
- M Friedmann
- M Goldbloom
- M Grob
- M Grob
- M Grob
- M Grob
- M Grob
- M Halipre
- M Herbst
- M Holzmann
- M Honey
- M Jequier
- M Kahn
- M Kartagener
- M Kühne
- M Langeron
- M Lev
- M Lev
- M Lev
- M Lillian
- M Lingen van
- M Lipson
- M Lubert
- M Löweneck
- M MacLeod
- M Mandelstamm
- M Mouquin
- M Nagel
- M Roch
- M Segers
- M Segers
- M Segers
- M Sewart
- M Silvestrini
- M Sossai
- M Stahlmann
- M Ursini
- M Vizcaino
- M Wahl
- M Watson
- M Weinbren
- MA Chiechi
- MA Dollfus
- MA Engle
- MA Engle
- MA Engle
- MA Kugel
- MB Ariel
- MB Copleman
- MC Achard
- MC McCord
- MCF Lindert
- McKinley
- MD Altschle
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- ME Abbott
- Meckel
- MF Joly
- MF Moses
- MF Steinberg
- MF Steinberg
- MF Steinberg
- MG Austin
- MG Desai
- MG Stevens
- MH Uhley
- MH Wittenborg
- MH Wittenborg
- MJ Askey
- MJ Carson
- MJ Hubeny
- MJ Reeh
- MJ Shapiro
- MK Ledbetter
- ML Carnes
- ML Susman
- ML Young
- MM Figley
- MM Glendy
- MR Drennan
- MV Cruz De La
- MV Pfaundler
- MW Arthurron
- N Coulshed
- N Kusnetzowsky
- N Oeconomos
- N Schad
- N Schad
- N Schad
- N Tanner-Cain
- NA Halasz
- NB Everett
- NE Freeman
- NE Reich
- NF Trench
- NG Demy
- NR Barrett
- NR Konar
- NS Donavan
- NS Talner
- NW Philpott
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Bayer
- O Fraentzel
- O Garcia
- O Heitzmann
- O Hueck
- O Krausse
- O Müller
- O Petersen
- O Saphir
- O Schleckat
- O Storstein
- O Storstein
- O Wenner
- Oberwinter
- OC Brantigan
- OC Railsback
- OH Wangenstein
- OR Morgan
- OS Tubbs
- OW Husebye
- O’Bryan
- P Adams
- P Adams
- P Amundsen
- P Batchelder
- P Belou
- P Broustet
- P Cachen
- P Calazel
- P Charrague
- P Chiche
- P Corone
- P Cossio
- P Delthil
- P Fleming
- P Formijne
- P Galle
- P Geipel
- P Gellert
- P Huard
- P Kezdi
- P Krepler
- P Laurens
- P Merklen
- P Mouren
- P Quintin
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- P Schölmerich
- P SouliÉ
- P SouliÉ
- P Soulié
- P Soulié
- P Soulié
- P Soulié
- P Stumpf
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Thurn
- P Vernaut
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- P Wood
- P Wood
- P Wood
- P Zagorsky
- P ödman
- P ödman
- P ödmann
- PA Herbut
- PBN Odgers
- PD White
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- PH Davison
- PH Futcher
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- PI Halonen
- PJD Snow
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- PN Yu
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- PW Gebauer
- PW Speschilow
- R Adams
- R Ash
- R Bilger
- R Brock
- R Bulgarelli
- R Debré
- R Fono
- R Gelfman
- R Gürtler
- R Hagen
- R Hanna
- R Heim De Balsac
- R Heim de Balsac
- R Heim De Balsac
- R Heim De Balsac
- R Heim de Balsac
- R Heim De Balsac
- R Heim de Balsac
- R Janker
- R Janker
- R Janker
- R Janker
- R Janker
- R Kilby
- R Kunzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Künzler
- R Limon Lason
- R Lutembacher
- R Mohr
- R Nicks
- R Paltauf
- R Pannier
- R Pape
- R Pavlitzek
- R Potts
- R Praagh van
- R Quain
- R Quain
- R Rippert
- R Rippert
- R Robertson
- R Rössle
- R Schatzki
- R Schmaltz
- R Shaw
- R Stintzing
- R Thoma
- R Vernejoul De
- R Wenger
- R Wilson
- R Zenker
- R Zuckermann
- RA Bruce
- RA Deterling Jr.
- RA Deterling Jr.
- RA Deterling Jr.
- RA Furman
- RA Lyon
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- RD Lockhart
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- RF Grover
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- RF Grover
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- RF Shaner
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- RH Balsac
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- RJ Bing
- RJ Bing
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- RM Stewart
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- RN Paul
- RO Brandenburg
- RO Brigham
- RP Allen
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- RP Grant
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- RS Cosby
- RS Cosby
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- RW Alexander
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- RW Collett
- RW Dickson
- RW Scott
- RX Zittel
- S Bellet
- S Berber
- S Bleifer
- S Buchs
- S Buchs
- S Cheu
- S Contro
- S Dack
- S Eek
- S Effert
- S Effert
- S Farber
- S Gibson
- S Gibson
- S Gibson
- S Gibson
- S Gordon
- S Howard
- S Howath
- S Kejlson
- S Mackler
- S McGinn
- S McLean
- S Millman
- S Novelo
- S Oram
- S Sailer
- S Sailer
- S Sanes
- S Scheef
- S Schorr
- S Seiler
- S Skapinker
- S Uchida
- S Wilkes
- SA Levine
- SC Blount
- SC Mitchell
- SC Shattock
- SE Courter
- SE Gould
- SE Gould
- SE Gould
- SG Blount
- SG Blount
- SG Blount
- SG Blount Jr.
- SG Blount Jr.
- SG Shepherd
- SGr Blount
- SH Marder
- SI Seldinger
- SJ Powell
- SL Burwell
- SO Wasastjerna
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Kjellberg
- SR Levine
- SRF Whittacker
- SS Lichtman
- St Mahrburg
- ST Sömmering
- St Zacharioudakis
- SW Hunter
- Symington
- Symptomatische Pulmonalstenose
- T Fisher
- T Lewis
- T Munkner
- T Peacock
- TB Peacock
- TB Peacock
- TF Hilbish
- TF Hubbard
- Th Bothwell
- TH Burford
- Th Cowie
- Th Hornykiewitsch
- TI Dry
- TJ Dry
- TM Welsh
- TO Dorrance
- TW Griffith
- TW Griffith
- TY Dry
- UI Roche
- V Beato Nunez
- V Eisenmenger
- V Eskelund
- V Malacarne
- V Moragues
- V Moragues
- V Rubio
- V Salle
- V Schilling
- V Sprenkel
- V Thaden
- VA McKusick
- VA McKusick
- Varco
- VB Dolgopol
- VB Dolgopol
- VG Brekke
- VL Gott
- VO Björk
- VO Björk
- W Bircks
- W Bridgen
- W Coulson
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Doerr
- W Dressler
- W Evans
- W Evans
- W Ewald
- W Falholt
- W Gerok
- W Gerok
- W Graf
- W Gruber
- W Haggenmiller
- W Harvey
- W Heck
- W Heek
- W Herzog
- W Hickman
- W Jegier
- W Krause
- W Müller
- W Porstmann
- W Porstmann
- W Porstmann
- W Risel
- W Roessler
- W Schulze
- W Schweizer
- W Siegenthaler
- W SipilÄ
- W Smull
- W Teschendorf
- W Turner
- W Weitz
- W Whitaker
- W Whitaker
- W Zinn
- WA Wimsatt
- WB Bean
- WB Civin
- WB Porter
- WC Schraft
- WCD Richards
- WD Hurst
- WE Medd
- Weiss-Eder
- WF Bugden
- WF Doolittle
- WF Kraemer
- WF Weaver
- WF Windle
- WG Gunteroth
- WG McCallum
- WG Mitchell
- WG Smith
- WH Muller
- WH Muller
- WH Pritchard
- WH Welch
- WI Potts
- Wieting
- Winslow
- WJ Atwell
- WJ Brown
- WJ Elliot
- WJ Muller Jr.
- WJ Patterson
- WJ Porter
- WJ Potts
- WJ Potts
- WK Purks
- WL Riker
- WM Yater
- WP Cleland
- WP Herringham
- WPO Hwang
- WR Livesay
- WS Church
- WS Conklin
- WS Greenfield
- WS Hastings
- WS Love Jr.
- WS Tinney
- WS Tinney Jr.
- WS Tinney Jr.
- WT Mustard
- WT Mustard
- WT Mustard
- WT Mustard
- WW Beattie
- WW Fray
- WW Herrmann
- WW Meyer
- WW Wagstaffe
- Y Larsson
- YS Palladino
- Z Belobradek
- — Die Mißbildungen des menschlichen Herzens. Ergebn. allg. Path. path
- —La double crosse aortique
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1967
- Field of study