3 research outputs found
Response to Heterologous Leishmanins in Cutaneous Leishmaniasis in Nigeria: Discovery of a New Focus
Response to heterologous leishmanins in cutaneous Leishmaniasis in Nigeria - Discovery of a new focus
A pilot study was undertaken to preliminary illustrate the leishmanin
skin test (LST) positivity to distinct antigen preparations (derived
from promastigote of either Leishmania major or L. amazonensis, or
pooled L. mexicana, L. amazonensis and L. guyanensis) in cutaneous
leishmaniasis (CL) patients and healthy subjects living in two endemic
foci in Nigeria. The study was designed to provide insights into
whether cross-species leishmanin, such as that prepared from New World
Leishmania could be useful to detect cases of Old World leishmanial
infection and to compare the results with LST using L. major-derived
leishmanin. The overall LST positivity in individuals from Keana tested
with the cross-species leishmanin was 28.7% (27/94), while the
positivity rate in the subjects from Kanana tested with the same
leishmanin was 54.5% (6/11). Lower positivity values were obtained when
L. major (12.5%; 11/88) or L. amazonensis (15.8%; 9/57) was tested as
antigen in grossly comparable populations. Moreover, the pooled
leishmanin identified most of the subjects (13/14; 92.9%) with active
or healed CL, and the maximum reaction sizes were found among positive
subjects in this group. No healthy controls (10 total) showed specific
DTH response. The LST was useful for assessing the prevalence of
subclinical infection and for measuring CL transmission over time. We
report for the first time the occurrence of CL in Kanana village of
Langtang South local government area of Plateau State