The prophylaxis of major bacterial infections in the Apis mellifera carpathica bee through honey, pollen and bee bread control

For the purpose of controlling the evolution of major bacterial diseases in bees, which decimate bee colonies in Europe and Romania, respectively, we examined samples (honey, pollen and honeycombs) in the apicultural year 2016, from all over Romania. Sample collection and testing were done with the purpose to prevent the contamination of bee colonies with the etiological agents of major bacterial diseases, considering that worker bees and the food entering the hive (honey, pollen) represent the main contamination ways. The diagnosis method observed OIE regulations (2008) and was adapted in an original way in the Bee Pathology Laboratory in Bucharest. A total of 73 samples were examined, representing honey (51), honeycombs (6) and pollen/bee bread (16), from private apiaries all over the country, that presented depopulation without clinical evolution of contagious diseases in bees, and in which we diagnosed the presence of etiological agents of major bacterial bee diseases (36.98 %), while the rest of the samples were negative (63.02%). Of the 51 samples of honey that were examined, we identified 39.22% positive samples and 60.78% negative ones. Of the pollen samples that were examined, 31.25% were positive and 68.75% were negative, and the honeycombs samples showed 33.33% positive and 66.66% negative. Previous researches indicated that the positive samples (honey, pollen, bee bread), from apiaries in all the regions of the country, represented the basis for the prophylaxis of major bacterial diseases so that, by avoiding using them in bee nutrition, the evolution of major bee diseases did not confirm clinically or paraclinically in the following season (January-April 2017)

Aviation industry - challenges and uncertainties after the Covid-19 pandemic

Research background: After the recent restart of global economy, at least in Asia, Europe and U.S., one of the main suffering industries is aviation. As a principal consequence of quarantine and closing borders, most of the people cancelled their flights pushing the airlines companies to the edge of abyss therefore it looks interesting to understand how far they could go and what the operating limit are. If at the moment we have heard news about bankruptcy only about few companies (LGW –a regional German airline and Latam Airlines - South America’s biggest carrier) is because, generally, they still have cash reserves and important demands for help was sent to the governments but the situation is quite dramatic. Purpose of the article: In this article we will analyse why the aviation sector is facing one of the most complicated times after the 9/11 WTO, what are the main constraints for the industry future and what real measures can be taken in order to recover the situation. Methods: By means of descriptive and comparative analysis the paper reveals the financial and technical difficulties to implement certain health safety rules imposed by regulators. Findings & Value added: This new type of pressure caused by Covid-19 pandemic outlines once again the stress in which the aviation sector is found out. Despite the fact that there is a permanent preoccupation to improve technology and performance, governments and health international organisation should take into consideration all the business aspects before launching impossible requests

THE PHYSICIAN – PATIENT RELATION IN THE ACTUAL ECONOMICOSYSTEMIC CONTEXT (CRISIS OF THE SANITARY SYSTEM)

In România, the crisis of the sanitary system is a component of the generalized economic-social crisis manifested in the 90’s, concomitantly with the sudden demolition of the centralized production system. The opportunities of public health, determined in relation with the “health market”, on the basis of the demand-supply intercourse, have been either ignored by the political factors or managed asymmetrically to the basic principles of the new system, most frequently in the absence of minimal financing. In this way, the quality of the therapeutical action becomes uncertain, insufficient, quantitatively and qualitatively regressing, reflecting, in a structural way, the losses caused by the ever-increasing migration of the Romanian medical specialists. The present diagnosis of the health status in Romania reveals severe, inconsistent realities, that can be systemically controlled only by a modulated, appropriate and effective management, and by a suitably-sized financing of capital expenditure and staff

Comparative analysis of taxation in 8 ex-communist countries in Europe

Research background: Having a similar background before the 1990, the ex-communist countries in Europe started to differentiate one from another in terms of social and economic development. Nowadays, in many aspects of the socio-economic environment, the differences between them are significant. There are many factors to be considered when analysing the patterns of evolution of each ex-communist country in Europe and one of them is taxation. The level of taxation can lead to structural changes in the economy, especially market economies that are not mature. Purpose of the article: The purpose of this article is to compare the level of taxation in 8 EU ex-communist countries: Bulgaria, Croatia, Czech Republic, Hungary, Romania, Poland, Slovakia, and Slovenia - in the context of globalization. Methods: We will do a comparative analysis of the indicators developed by European Commission, DG Taxation and Customs Union and Eurostat of the 8 EU ex-communist countries. Findings & Value added: This paper may add value to the economic and tax policies in the 8 EU ex-communist countries by identifying the policies that proved their effectiveness in generating higher labor productivity, policies that can be adapted and then adopted by the UE ex-communist countries that are less developed. Moreover, this paper can lead to more in-depth research concerning taxation as significant factor of development in these countries

A Challenging Case of Kikuchi-Fujimoto Disease Associated with Systemic Lupus Erythematosus and Review of the Literature

Kikuchi–Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare disease that is frequently underdiagnosed due to clinical features that are similar to those of non-Hodgkin lymphomas, systemic lupus erythematosus (SLE), or infectious reactive lymphadenopathy. An excisional biopsy is required. We report a young Caucasian female diagnosed with KFD with skin lesions, complicating with SLE. The clinical course, laboratory, and CT findings are described, as are histopathologic features, for a better recognition of this rare disorder in clinical practice

Essential Thrombocythemia: One-Center Data in a Changing Disease

Introduction: Essential thrombocythemia is a chronic myeloproliferative neoplasm associated with thrombo-hemorrhagic events and the progression to myelofibrosis or acute myeloid leukemia. The purpose of this article is to present real-world data on ET cases diagnosed and managed between 1998 and 2020 in the largest, tertiary hematology reference center in Romania and to evaluate the impact of thrombotic events on survival. Methods: A real-world, retrospective cohort-type study was conducted. We collected and statistically analyzed data from 168 patients who met the 2016 WHO diagnostic criteria for ET and who were managed between 1998 and 2020 in our center. Results: The median age at diagnosis of ET was 51.8 years, with a female predominance (66.07%). The JAK2V617F mutation was detected in 60.71% of patients. Leukocytosis at diagnosis was associated with a higher risk of thrombosis, and JAK2V617F-positive cases exhibited a 1.5-fold higher risk of developing thrombotic events. The average survival in ET with major thrombosis was 14.5 years versus 20.6 years in ET cases without major thrombosis. Other predictors of survival were high-risk IPSET score and age >60 years. Conclusions: Romanian patients diagnosed with ET are generally younger than 60 years and are predominantly female. The occurrence of thrombotic events was influenced by gender, leukocyte count at diagnosis and JAK2V617F positivity. Survival was impacted by age, the presence of JAK2V617F mutation, hypertension, major thrombotic complications and IPSET score. Notably, these findings warrant careful interpretation and further confirmation in the setting of prospective studies

The Use of Sholl and Kolmogorov Complexity Analysis in Researching on the Sustainable Development of Creative Economies in the Development Region of Bucharest‒Ilfov, Romania

Nowadays, creative economies stand as a relevant indicator of the sustainable development of local and regional ones. The study aims to highlight the spatial behaviour of creative economies in the Bucharest‒Ilfov Development Region, the most dynamic and complex regional economy in Romania. In order to assess the spatial dynamics of creative economies in the region, an economic database was created, at the level of the territorial administrative unit, for the two economic indicators considered important for the study, number of employees and turnover, under the auspices of the Classification of National Economy Activities (NACE). The establishment of creative economies was made following the Government Decision no. 859 of 2014, with 66 codes for this sector. Annual cartographic models were developed for each indicator in QGIS (a free and open–source cross–platform desktop geographic information system application that supports viewing, editing, and analysis of geospatial data), for the period 2000–2016. For a relevant analysis of spatial behaviour, we used Sholl and Kolmogorov complexity, which highlighted specific patterns of spatial dynamics that help us to understand the role of creative economies in the sustainable development of regional economies. The results highlighted the role of accessibility corridors in the development of the regional economy

O OR RI IG GI IN NA Transitional cell tumors of the ovary: a compact group with a heterogeneous histological and immunophenotypical pattern

Abstract A small percentage of ovarian neoplasms are transitional cell tumors, which proves to be a distinct group with various histological and immunohistochemical patterns. In this study, 13 archived formalin-fixed paraffin-embedded samples of transitional cell tumors of the ovary have been assessed using standard HE stain and the indirect tristadial ABC peroxidase IHC method for 11 antibodies (CA125, CK7, CEA, EMA, MNF116, CK20, Vim, ER, PgR, PCNA, Ki-67). More than 50% were malignant Brenner tumors. CA125 was positive in all malignant tumors (of Brenner type and transitional cell carcinomas), but not in benign and borderline tumors, while CK7 was positive in ~70% of all cases. These two antibodies have shown a high sensitivity and low specificity, but do not correlate to each other. PCNA was positive in the study batch with a mean value of 40% and Ki-67 with a mean value under 25%. A direct correlation statistically significant has been noted between the aforementioned proliferation factors and the tumor grade (r = 0.4, p = 0.05). The other markers were unspecific, with low sensitivity and independently of the histopathological type