8 research outputs found
Association of blood pressure variability with orthostatic intolerance symptoms
<div><p>The short-term blood pressure variability (BPV) reflects autonomic regulatory mechanisms. However, the influence of BPV in orthostatic intolerance (OI) is unknown. Herein, we assessed BPV profiles in patients with OI and determined their association with orthostatic symptoms. In this cross-sectional study, we prospectively enrolled 126 patients presenting with OI at the Seoul National University Hospital from December 2014 to August 2016. Among them, those with other neurological diseases (n = 8) and insufficient BP measurements (n = 15) were excluded. The degree of OI symptoms were measured using the self-administered orthostatic intolerance questionnaire (OIQ). All patients underwent ambulatory BP monitoring and we calculated the standard deviation and coefficient of variation as a measure of BPV. The mean age was 48.6 years and the average of the total OIQ score was 11.6. The severe OI group had higher BPV values than the mild group, although mean BP profiles did not differ significantly. Correlation analysis demonstrated that the orthostatic symptoms were positively correlated with diastolic BPV for the total and awake periods. Multiple linear regression analysis revealed that diastolic BPV (<i>B</i> = 0.46, p = 0.031) and current smoking (<i>B</i> = 4.687, p = 0.018) were independent factors for higher OI symptom scores after adjusting for covariates. The results of the current study demonstrated that a positive correlation exists between BPV and OI symptoms. Further studies are required to confirm the present findings and understand the neural mechanisms contributing to the excessive BPV in patients with OI.</p></div
Scatter plots between blood pressure variability and total orthostatic intolerance questionnaire (OIQ) scores (n = 103).
<p>(A) Diastolic blood pressure variability measured by the coefficient of variation (DBPV<sub>CV</sub> [%]) for total recordings. (B) DBPV<sub>CV</sub> (%) during the awake period. (C) Comparison of total OIQ scores between the high (n = 52) and low (n = 51) BPV groups. The cut-off value of total DBPV<sub>CV</sub> was 10%, and that of awake DBPV<sub>CV</sub> was 10.1%. * p < 0.05. Error bars indicate the standard deviation.</p
Correlation between blood pressure variability and orthostatic intolerance symptom scores.
<p>Correlation between blood pressure variability and orthostatic intolerance symptom scores.</p
Multiple linear regression analyses for orthostatic intolerance symptom scores.
<p>Multiple linear regression analyses for orthostatic intolerance symptom scores.</p
Orthostatic intolerance questionnaire scores for each item in total patients (n = 103).
<p>Each item score ranges from 0 to 4 according to the frequency of orthostatic symptoms.</p
Clinical characteristics and ambulatory blood pressure measurement profiles.
<p>Clinical characteristics and ambulatory blood pressure measurement profiles.</p
Additional file 1: Table S1. of Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome
Correlations among the questionnaire parameters (full details). Table S2. Univariate analysis for a significant functional deterioration. (DOCX 34 kb
Additional file 1: Table S1. of Orthostatic intolerance symptoms are associated with depression and diminished quality of life in patients with postural tachycardia syndrome
Correlations among the questionnaire parameters (full details). Table S2. Univariate analysis for a significant functional deterioration. (DOCX 34 kb