78 research outputs found
Factors affecting career turnover intention after graduation among nursing students: A cross-sectional study in Central Vietnam
Background & Aim: Turnover intention can predict the actual turnover behavior of nurses. Previous studies identified a variety of factors influencing nurses' turnover intention. However, few studies investigate nursing students' career turnover intention. This study aimed to examine turnover intention and associated factors among nursing students in Central Vietnam.
Methods & Materials: A cross-sectional study was implemented among 425 nursing students recruited through a multistage sampling technique from April to May 2022. Data were collected using a questionnaire including demographic characteristics, fear of COVID-19, perceived academic stress, and turnover intention. Descriptive statistics were used to describe demographic characteristics and study variables. Independent t-test, one-way analysis of variance, and Pearson's correlation coefficients were computed to examine the association between variables.
Results: Approximately one-third (32.5%) of the respondents will look for jobs without patient contact, 32.2% would not study nursing if given a choice, and 31.1% often think of not staying in the nursing profession. The sum scores of turnover intention ranged from 3 to 15 with a mean of 9.19 (SD= 2.49). The turnover intention was associated with the year of study, the reason to study nursing, and preparation for nursing school (p<.05). Perceived academic stress had a moderate correlation with turnover intention (r= -.325, p<.05). In contrast, the association between fear of COVID-19 and turnover intention was not significant.
Conclusion: A considerable number of nursing students had turnover intention upon graduation. Factors affecting turnover intention should be considered to retain students in educational programs and avoid a future nursing shortage
Using metagenomics tool to evaluate the enrichment efficiency of methanogens in marine sediment in Truong Sa archipelage, Khanh Hoa province, Vietnam
Methanogens (archaea bacteria that produce methan) play an important role in the anaerobic digestion of organic waste, however, in marine environment, the low density of methanogens makes anaerobic digestion very slow. In this study, we used methagenomics tool to evaluate the enrichment efficiency of methanogens communities in marine sediments as a basis for building a anaerobic microbial formulation to treat organic waste in marine environment. The results of determination of methanogen density by MPN method have shown that methanogen has been accumulated with higher density (up to 3.2.107 MNP/ml) through 2 times of enrichment in artificial seawater with CH3COONa 10 mM substrate. In addition, metagenomics data have also shown a decrease in the number of archaea species through each enrichment, indicating that methanogenic species have gradually dominated the microbial community. This is the first study on using metagnenomics tools to evaluate the enrichment of methanogens in marine sediment samples in Truong Sa archipelago, Vietnam. Metagenomics data help provide more reliable evidence in microbial studies, especially in obligate anaerobes such as methanogens
Structure elucidation off seven steroids from Sinularia conferta.
Seven steroids were isolated from the methanol extract of the soft corals Sinularia conferta. These steroids were elucidated as 7a-methoxyergosta-5,24(28)-diene-3b-ol (1), ergosta-5-ene-3Ī²,7Ī±-diol (2), 3Ī²,7Ī±-dihydroxyergosta-5,24(28)-diene (3), 3Ī²-hydroxyergosta-5,24(28)-diene-7-one (4), ergosta-24(28)-ene-3Ī²,5Ī±,6Ī²-triol-6-acetate (5), ergosta-24(28)-ene-3Ī²,5Ī±,6Ī²-triol (6), and ergosta-3Ī²,5Ī±,6Ī²-triol (7) by 1D and 2D-NMR experiments and comparison with reported data. Keywords. Sinularia conferta, Alcyoniidae, soft coral, steroid
Saponins isolated from the Vietnamese sea cucumber Stichopus chloronotus.
Using various chromatographic methods, three triterpene saponins neothyonidioside (1), stichoposide D (2), and holothurin B (3), were isolated from the methanol extract of the sea cucumber Stichopus chloronotus. Their structures were elucidated by 1D and 2D-NMR experiments and comparison of their NMR data with reported values. Compound 1 was isolated from S. chloronotus for the first time
CHOLESTANE-TYPE STEROIDS FROM THE OCTOCORAL Verrucella corona
Using various chromatographic separations, three cholestane-type steroids were isolated from the methanol extract of the octocoral Verrucella corona. Their structures were elucidated to be (22E)-cholesta-5,22-dien-3Ī²-ol-7-one (1), trans-liagosterol (2), and guggulsterol-II (3), by detailed analysis of the 1D and 2D-NMR data as well as comparison with those reported. Among them, compound 2 showed significant cytotoxicity against eight human cancer cell lines as HepG2, HL-60, KB, LNCaP, LU-1, MCF7, SK-Mel2, and SW480
STRUCTURE ELUCIDATION OF FOUR STEROIDS FROM THE SOFT CORAL SINULARIA NANOLOBATA
Four steroids namely 3Ī²-hydroxyergosta-5,24(28)-diene-7-one (1), dissesterol (2), 16Ī±-hydroxysarcosterol (3), and sarcophytosterol (4) were isolated form the soft coral Sinularia nanolobata using various chromatographic methods. Their structures were elucidated by detailed analysis of the 1D and 2D NMR data and comparison with the reported values
Investigating the Effect of Future Orientation on Saving Intention of Generation Zās University Students in Vietnamās Northern Region
Young people are often thought to have a lifestyle focusing on enjoyment, which is why issues related to saving among the youth, especially saving money, receive significant attention from society. This issue has been analyzed in some previous studies; however, there is a new factor that has not been explored in the context of Vietnam, which is future orientation. The purpose of this study is to find out the relationship between future orientation, attitude towards saving and saving intention of generation Z university students in Northern Vietnam. The research method used was the combination of qualitative and quantitative methods. The primary data was collected from 531 respondents who are currently studying at universities in Northern Vietnam and the data was analyzed by using SPSS and AMOS software. The structural equation modeling (SEM) method was used, and the results indicate that both future orientation and attitude towards saving have a positive impact on savings intention. Furthermore, the mediating role of attitude in the relationship between future orientation and saving intention was confirmed. Therefore, the results should be applied by governmental agencies, financial organizations and individuals, especially young people, to encourage saving intention, and furthermore, saving behavior
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Incidence of AIDS-Defining Opportunistic Infections and Mortality during Antiretroviral Therapy in a Cohort of Adult HIV-Infected Individuals in Hanoi, 2007-2014
Background: Although the prognosis for HIV-infected individuals has improved after antiretroviral therapy (ART) scale-up, limited data exist on the incidence of AIDS-defining opportunistic infections (ADIs) and mortality during ART in resource-limited settings. Methods: HIV-infected adults in two large hospitals in urban Hanoi were enrolled to the prospective cohort, from October 2007 through December 2013. Those who started ART less than one year before enrollment were assigned to the survival analysis. Data on ART history and ADIs were collected retrospectively at enrollment and followed-up prospectively until April 2014. Results: Of 2,070 cohort participants, 1,197 were eligible for analysis and provided 3,446 person-years (PYs) of being on ART. Overall, 161 ADIs episodes were noted at a median of 3.20 months after ART initiation (range 0.03ā75.8) with an incidence 46.7/1,000 PYs (95% confidence interval [CI] 39.8ā54.5). The most common ADI was tuberculosis with an incidence of 29.9/1,000 PYs. Mortality after ART initiation was 8.68/1,000 PYs and 45% (19/45) died of AIDS-related illnesses. Age over 50 years at ART initiation was significantly associated with shorter survival after controlling for baseline CD4 count, but neither having injection drug use (IDU) history nor previous ADIs were associated with poor survival. Semi-competing risks analysis in 951 patients without ADIs history prior to ART showed those who developed ADIs after starting ART were at higher risk of death in the first six months than after six months. Conclusion: ADIs were not rare in spite of being on effective ART. Age over 50 years, but not IDU history, was associated with shorter survival in the cohort. This study provides in-depth data on the prognosis of patients on ART in Vietnam during the first decade of ART scale-up
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Longāterm viral suppression and immune recovery during firstāline antiretroviral therapy: a study of an HIVāinfected adult cohort in Hanoi, Vietnam
Abstract Introduction: Achieving viral suppression is key in the global strategy to end the HIV epidemic. However, the levels of viral suppression have yet to be described in many resourceālimited settings. Methods: We investigated the time to virologic failure (VF; defined as a viral load of ā„1000 copies/ml) and changes in CD4 counts since starting antiretroviral therapy (ART) in a cohort of HIVāinfected adults in Hanoi, Vietnam. Factors related to the time to VF and impaired early immune recovery (defined as not attaining an increase in 100 cells/mm3 in CD4 counts at 24 months) were further analysed. Results: From 1806 participants, 225 were identified as having VF at a median of 50 months of firstāline ART. The viral suppression rate at 12 months was 95.5% and survival without VF was maintained above 90% until 42 months. An increase in CD4 counts from the baseline was greater in groups with lower baseline CD4 counts. A younger age (multivariate hazard ratio (HR) 0.75, vs. <30), hepatitis C (HCV)āantibody positivity (HR 1.43), and stavudine (d4T)ācontaining regimens (HR 1.4, vs. zidovudine (AZT)) were associated with earlier VF. Factors associated with impaired early immune recovery included the male sex (odds ratio (OR) 1.78), HCVāantibody positivity (OR 1.72), d4Tābased regimens (OR 0.51, vs. AZT), and nevirapineābased regimens (OR 0.53, vs. efavirenz) after controlling for baseline CD4 counts. Conclusion: Durable highārate viral suppression was observed in the cohort of patients on firstāline ART in Vietnam. Our results highlight the need to increase adherence support among injection drug users and HCV coāinfected patients
A polyhydroxylated sterol and a saponin isolated from the starfish culcita novaeguineae
Using various chromatographic methods, a polyhydroxylated sterol 5Ī±-cholestane-3Ī²,6Ī²,7Ī±,8Ī²,15Ī±,16Ī²,26-heptol (1) and an asterosaponin sodium salt of 6Ī±-[(O-Ī²-D-fucopyranosyl-(lĀ®2)-O-Ī²-D-galactopyranosyl-(lĀ®4)-O-[Ī²-D-quinovopyranosyl-(lĀ®2)]-O-Ī²-D-xylopyranosyl-(lĀ®3)-O-Ī²-D-quinovopyranosyl)oxy]-5Ī±-pregn-9(11)-ene-20-one (2), were isolated from the methanol extract of the starfish Culcita novaeguineae. Their structures were elucidated by 1D and 2D-NMR experiments and comparison of their NMR data with reported values. Compounds 1 was isolated from Ā Ā Ā Ā Ā Ā Ā Ā C. novaeguineae for the first time
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