1 research outputs found
Expanding Synthesizable Space of Disubstituted 1,2,4-Oxadiazoles
One-pot synthesis of 3,5-disubstituted
1,2,4-oxadiazoles from carboxylic
acids and nitriles was optimized to parallel chemistry. The method
was validated on a 141 member library; the desired products were recovered
with a high success rate and in moderate yields. Practical application
of the approach was demonstrated in the synthesis of bioactive compound
pifexole and agonists of free fatty acid receptor 1. A library of
4 948 100 synthesizable drug-like 3,5-disubstituted
1,2,4-oxadiazoles was enumerated based on the method and available
validated reagents