1 research outputs found
New Degradable Semiconducting Polymers for Photoacoustic Imaging of λ‑Carrageenan-Induced Arthritis Mouse Model
Semiconducting polymer has a high extinction coefficient
and a
long band absorption and can be used as a photoacoustic imaging contrast
agent. However, nonbiodegradable semiconducting polymers may cause
biosafety issues due to being retained in the body. Therefore, developing
degradable semiconducting polymers is necessary for in vivo imaging.
Herein, we developed three degradable semiconducting polymers with
unique optical properties. We adjusted the optical properties of semiconducting
polymers by designing the molecular structure of semiconducting polymers.
Polymers with a donor−π–acceptor structure could
easily improve the optical properties through adjusting the donor
or acceptor units. Through adjusting the electron-donor and -acceptor
units, three diketopyrrolopyrrole derivative polymers (DPPTz, DPPQu,
and DPPWu) were synthesized and converted into nanosize particles.
By introducing the degradable chemical groups in the main chain structure
of semiconducting polymers, diketopyrrolopyrrole polymers could be
degraded by ClO–. Among these nanosize particles,
DPPTz NPs and DPPQu NPs were used to achieve the in vivo photoacoustic
imaging of λ-carrageenan-induced arthritis mouse model. This
work provides a novel design idea for the designing of red-shifted
semiconducting polymer with degradable properties