2 research outputs found
Nucleophilic Ring Opening of Donor–Acceptor Cyclopropanes with the Cyanate Ion: Access to Spiro[pyrrolidone-3,3′-oxindoles]
The
nucleophilic ring opening of donor–acceptor cyclopropanes
with the cyanate ion is reported for the first time. Cyclopropanes,
spiro-activated with oxindole fragments as acceptors, are shown to
undergo transformations into biologically relevant spiroÂ[pyrrolidone-3,3′-oxindoles]
while being treated with potassium cyanate under microwave assistance
Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity
We
have synthesized and characterized a panel of new binuclear
mixed valence CuÂ(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4<i>H</i>-imidazolin-4-ones with unusual structure. These complexes
are shown to be cytotoxic for various cell lines. We have found that
these compounds did not intercalate DNA, inhibited number of polymerases
(telomerase predominantly), accumulated in the cell nucleus, and caused
DNA degradation. Preliminary studies revealed that lead compound inhibited
human breast adenocarcinoma growth in mice model