Heavy Quark Radiative Energy Loss - Applications to RHIC

Heavy quark energy loss in a hot QCD plasma is computed taking into account the competing effects due to suppression of zeroth order gluon radiation bellow the plasma frequency and the enhancement of gluon radiation due to transition energy loss and medium induced Bremsstrahlung. Heavy quark medium induced radiative energy loss is derived to all orders in opacity, $(L/\lambda_g)^n$. Numerical evaluation of the energy loss suggest small suppression of high $p_\perp$ charm quarks, and therefore provide a possible explanation for the null effects observed by PHENIX in the prompt electron spectrum in $Au+Au$ as $\sqrt{s}=130$ and 200 AGeV.Comment: 4 pages, 4 figures, Contributed to 17th International Conference on Ultra Relativistic Nucleus-Nucleus Collisions (Quark Matter 2004), Oakland, California, 11-17 Jan 200

Heavy-to-light ratios as a test of medium-induced energy loss at RHIC and the LHC

The ratio of nuclear modification factors of high-$p_T$ heavy-flavored mesons tolight-flavored hadrons (heavy-to-light ratio) is shown to be a sensitive tool to test medium-induced energy loss at RHIC and LHC energies. Heavy-to-light ratios of $D$ mesons at RHIC in the region $7<p_T<12$ GeV, and of $D$ and $B$ mesons at the LHC in the region $10<p_T<20$ GeV, are proposed for such a test. Finally, the different contributions to the nuclear modification factor for electrons at RHIC are analyzed. Preliminary PHENIX and STAR data are compatible with radiative energy loss provided the contribution of electrons from beauty decays is small compared to that from charm.Comment: 5 pages, latex, 4 eps figs included using graphicx; to appear in the proceedings of 18th International Conference on Ultrarelativistic Nucleus-Nucleus Collisions: Quark Matter 2005 (QM 2005), Budapest, Hungary, 4-9 Aug 200

Magnetic and electric contributions to the energy loss in a dynamical QCD medium

The computation of radiative energy loss in a finite size QCD medium with dynamical constituents is a key ingredient for obtaining reliable predictions for jet quenching in ultra-relativistic heavy ion collisions. It was previously shown that energy loss in dynamical QCD medium is significantly higher compared to static QCD medium. To understand this difference, we here analyze magnetic and electric contributions to energy loss in dynamical QCD medium. We find that the significantly higher energy loss in the dynamical case is entirely due to appearance of magnetic contribution in the dynamical medium. While for asymptotically high energies, the energy loss in static and dynamical medium approach the same value, we find that the physical origin of the energy loss in these two cases is different.Comment: 6 pages, 4 figure

MicroRNA-Regulated Signaling Pathways: Potential Biomarkers for Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and invasive type of pancreatic cancer (PCa) and is expected to be the second most common cause of cancer-associated deaths. The high mortality rate is due to the asymptomatic progression of the clinical features until the advanced stages of the disease and the limited effectiveness of the current therapeutics. Aberrant expression of several microRNAs (miRs/miRNAs) has been related to PDAC progression and thus they could be potential early diagnostic, prognostic, and/or therapeutic predictors for PDAC. miRs are small (18 to 24 nucleotides long) non-coding RNAs, which regulate the expression of key genes by targeting their 3′-untranslated mRNA region. Increased evidence has also suggested that the chemoresistance of PDAC cells is associated with metabolic alterations. Metabolic stress and the dysfunctionality of systems to compensate for the altered metabolic status of PDAC cells is the foundation for cellular damage. Current data have implicated multiple systems as hallmarks of PDAC development, such as glutamine redox imbalance, oxidative stress, and mitochondrial dysfunction. Hence, both the aberrant expression of miRs and dysregulation in metabolism can have unfavorable effects in several biological processes, such as apoptosis, cell proliferation, growth, survival, stress response, angiogenesis, chemoresistance, invasion, and migration. Therefore, due to these dismal statistics, it is crucial to develop beneficial therapeutic strategies based on an improved understanding of the biology of both miRs and metabolic mediators. This review focuses on miR-mediated pathways and therapeutic resistance mechanisms in PDAC and evaluates the impact of metabolic alterations in the progression of PDAC

Jet suppression of pions and single electrons at Au+Au collisions at RHIC

Jet suppression is considered to be a powerful tool to study the properties of a QCD medium created in ultra-relativistic heavy ion collisions. However, theoretical predictions obtained by using jet energy loss in static QCD medium show disagreement with experimental data, which is known as the heavy flavor puzzle at RHIC. We calculate the suppression patterns of pions and single electrons for Au+Au collisions at RHIC by including the energy loss in a finite size dynamical QCD medium, with finite magnetic mass effects taken into account. In contrast to the static case, we here report a good agreement with the experimental results, where this agreement is robust with respect to magnetic mass values. Therefore, the inclusion of dynamical QCD medium effects provides a reasonable explanation of the heavy flavor puzzle at RHIC.Comment: 4 pages, 2 figure

Transition Radiation in QCD matter

In ultrarelativistic heavy ion collisions a finite size QCD medium is created. In this paper we compute radiative energy loss to zeroth order in opacity by taking into account finite size effects. Transition radiation occurs on the boundary between the finite size medium and the vacuum, and we show that it lowers the difference between medium and vacuum zeroth order radiative energy loss relative to the infinite size medium case. Further, in all previous computations of light parton radiation to zeroth order in opacity, there was a divergence caused by the fact that the energy loss is infinite in the vacuum and finite in the QCD medium. We show that this infinite discontinuity is naturally regulated by including the transition radiation.Comment: 21 page, 22 figure

Chronic stress differentially affects antioxidant enzymes and modifies the acute stress response in liver of wistar rats.

Summary Clinical reports suggest close interactions between stressors, particularly those of long duration, and liver diseases, such as hepatic inflammation, that is proposed to occur via reactive oxygen species. In the present study we have used 21-day social isolation of male Wistar rats as a model of chronic stress to investigate protein expression/activity of liver antioxidant enzymes: superoxide dismutases (SODs), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GLR), and protein expression of their upstream regulators: glucocorticoid receptor (GR) and nuclear factor kappa B (NFkB). We have also characterized these parameters in either naive or chronically stressed animals that were challenged by 30-min acute immobilization. We found that chronic isolation caused decrease in serum corticosterone (CORT) and blood glucose (GLU), increase in NFkB signaling, and disproportion between CuZnSOD, peroxidases (CAT, GPx) and GLR, thus promoting H 2 O 2 accumulation and prooxidative state in liver. The overall results suggested that chronic stress exaggerated responsiveness to subsequent stressor at the level of CORT and GLU, and potentiated GLR response, but compromised the restoration of oxido-reductive balance due to irreversible alterations in MnSOD and GPx

Dietary fat intake as a risk factor for the development of diabetes. Multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGDS)

In the context of the Multinational MGSD Nutrition Study, three groups of subjects were studied: 204 subjects with recently diagnosed diabetes(RDM),42subjectswithundiagnoseddiabetes(UDM)(AmericanDiabetesAssociation criteria—fasting plasma glucose [FPG] 126 mg/dl), and 55 subjects with impaired fasting glucose(IFG)(FPG 110and126mg/dl).Eachgroupwascomparedwithacontrolgroupof nondiabetic subjects, matched one by one for center, sex, age, and BMI. Nutritional habits were evaluated by a dietary history method, validated against the 3-day diet diary. In RDM, the questionnaire referred to the nutritional habits before the diagnosis of diabetes. Demographic data were collected, and anthropometrical and biochemical measurements were taken. RESULTS— Compared with control subjects, RDM more frequently had a family history of diabetes(49.0vs.14.2%;P0.001),exercisedless(exerciseindex53.5vs.64.4;P0.01),and more frequently had sedentary professions (47.5 vs. 27.4%; P 0.001). Carbohydrates contributed less to their energy intake (53.5 vs. 55.1%; P 0.05), whereas total fat (30.2 0.5 vs. 27.8 0.5%; P 0.001) and animal fat (12.2 0.3 vs. 10.8 0.3%; P 0.01) contributed moreandtheplant-to-animalfatratiowaslower(1.50.1vs.1.80.1;P0.01).UDMmore frequentlyhadafamilyhistoryofdiabetes(38.1vs.19.0%;P0.05)andsedentaryprofessions (58.5vs.34.1%;P0.05),carbohydratescontributedlesstotheirenergyintake(47.61.7vs. 52.81.4%;P0.05),totalfat(34.71.5vs.30.41.2%;P0.05)andanimalfat(14.2 0.9 vs. 10.6 0.7%; P 0.05) contributed more, and the plant-to-animal fat ratio was lower (1.6 0.2 vs. 2.3 0.4; P 0.05). IFG differed only in the prevalence of family history of diabetes (32.7 vs. 16.4%; P 0.05). CONCLUSIONS— Our data support the view that increased animal fat intake is associated with the presence of diabetes