Navike u ishrani kao važan faktor očuvanja zdravlja kod učeničke i studentske populacije

Objective. Dietary habits influence different aspects of health, such as: subjective health assessment, life habits (such as physical activities), functional status, as well as the health care, where inadequate diet represents a significant risk factor for the formation of numerous, various health disorders. It is estimated that around 31% of children in the world under 5 is malnourished, while mortality caused by illness, hunger or malnutrition makes even 50% overall mortality in children. The basic aims of this research are to examine the dieting characteristics of pupils and students and the differences in these two groups' diet compared to their defined demographic and socio-economical features. Methods. A cross-section study has been done on the sample of 480 pupils and students in Nis. The research in the field was performed between 20th November and 2nd December in 2014 (special days for certain groups of subjects). As previously mentioned, a statistical package computing program Statistical Package for Social Sciences (SPSS for Windows rel. 13.0) was used. Results. The analysis shows that men have breakfast more rarely than women. The results are similar in answers to the question if they never have breakfast. Unlike the previous results, men have lunch more often than women and the answers to the question if they have an afternoon snack are similar. The difference is more apparent when it comes to afternoon snacks, men have lunch more often which is the same for the habit of having dinner or supper. An especially interesting question was the one whether subjects think about their health when they choose what to eat. The most frequent answer was that they consider it sometimes, a little less than a half or 45.2%, every third respondent, 29.0%, consider it often, and only every sixth does it always (16.3%). Conclusion. The most subjects sometimes thought about their health when they choose what to eat.Cilj. Navike u ishrani utiču na više različitih aspekata zdravlja, između ostalih na subjektivnu ocenu zdravlja, druge životne navike (kao što je fizička aktivnost), funkcionalni status, ali i korišćenje zdravstvene zaštite, a nepravilna ishrana predstavlja značajan faktor rizika za nastanak brojnih različitih poremećaja zdravlja. Procenjuje se da je oko 31% dece u svetu do 5 godina stare pothranjeno, dok smrtnost usled bolesti gladi i pothranjenosti učestvuje čak sa 50% ukupnog mortaliteta kod dece. Osnovni ciljevi istraživanja su da se ispitaju karakteristike ishrane učenika i studenata, kao i da se ispitaju razlike u ishrani učeničke i studentske omladine u odnosu na definisana demografska i socioekonomska obeležja ispitanika. Metode. Izvršena je studija preseka na uzorku od 480 učenika i studenata iz Niša. Terenski deo istraživanja sproveden je od 20. novembra do 02. decembra 2015. godine (posebni dani za određene grupe ispitanika). Korišćen je statistički paket-računarski program Statistical Package for Social Sciences (SPSS for WIndows rel. 13.0). Rezultati. Analiza pokazuje da muškarci ređe doručkuju u odnosu na osobe ženskog pola. Odgovori su jedino približni na pitanje da li nikada ne doručkuju za razliku od prethodnih rezultata muškarci redovnije ručavaju, a slični su odgovori u odnosu na to da li imaju poslepodnevnu užinu. U ostalim situacijama može se reći da devojke vode više računa o svom zdravlju. Posebno je bilo interesantno pitanje da li ispitanici pri izboru načina ishrane razmišljaju o svom zdravlju. Najučestalije izjašnjavanje bilo je da razmišljaju ponekad, nešto manje od polovine ili 45.2% često, svaki treći ispitanik ili 29.0%, a uvek, tek svaki šesti (16.3%). Zaključak. Većina ispitanika ponekad razmišlja o svom zdravlju kada bira šta da jede

Impact of genetics on neoadjuvant therapy with complete pathological response in metastatic colorectal cancer: case report and review of the literature

Treatment of colorectal metastatic cancer is still challenging, despite recent improvements in chemotherapy. A genetic cancer profile, such as the KRAS (Kirsten rat sarcoma) gene status, plays a key role in individualized tailored therapy. Molecular targeted therapy added to neoadjuvant chemotherapy can achieve a better pathological response and prolong survival. Pathological complete response of colorectal cancer stage N is rare. A 47-year-old female patient presented with rectal adenocarcinoma and three liver metastases (cT3d/4, N2, M1). After seven cycles of Bevacizumab and CAPOX in neoadjuvant setting, we noted more than 70.0% regression of metastases and complete regression of the primary tumor. We performed low anterior resection of rectum and synchronous subsegmental resection of S3, because the other two lesions were not detectable. Pathology revealed complete response of the primary and also secondary tumors. After 8 months, diagnostic tests did not show any sign of recurrence and the remaining liver lesions disappeared. Colorectal cancer is a heterogeneous disease and it is necessary to identify patients who are at-risk of recurrence and suitable for neoadjuvant therapy. Genetic biomarkers play an important role in metastatic colorectal cancer treatment. Because of the mutated KRAS gene, Bevacizumab was added to cytotoxic therapy achieving a complete pathological response of primary tumor and metastasis. This case is unique because all reported cases with similar results, described staged surgery and one of reverse staged surgery, but with similar results. This neoadjuvant therapy has extra ordinary results for colorectal cancer stage IV and can help disease-free and long-term survival