Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study

<div><p>Objectives</p><p>Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of the severity of CO poisoning. This weak indicator may be a result of the delay between poisoning occurrence and the blood assay. Two apparatuses, CO oximeters and exhaled CO analyzers, now permit COHb to be determined outside hospitals. Our hypothesis is that these instruments allow the early measurement of COHb concentrations, which are more correlated with the severity of poisoning, expressed using the poisoning severity score (PSS).</p><p>Design</p><p>In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.</p><p>Setting</p><p>Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.</p><p>Participants</p><p>All patients with CO poisoning reported to the French Surveillance System of CO poisoning.</p><p>Results</p><p>There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p<0.0001). A significant difference in the values of exhaled CO was also observed between PSS groups (p = 0.006), although the relationship was not linear.</p><p>Conclusions</p><p>The COHb concentrations measured using CO oximetry, but not those measured using exhaled CO analyzers, were well correlated with the severity of CO poisoning.</p></div

Relationship between COHb measurement by blood assay (in %) and PSS.

<p>Relationship between COHb measurement by blood assay (in %) and PSS.</p

Poisoning severity score (adapted from Persson et al. [9]).

<p>Poisoning severity score (adapted from Persson et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174672#pone.0174672.ref009" target="_blank">9</a>]).</p

Relationship between COHb measured by CO oximetry (in %) and PSS.

<p>Relationship between COHb measured by CO oximetry (in %) and PSS.</p

Flow chart showing the types of assays performed.

<p>Flow chart showing the types of assays performed.</p

Relationship between exhaled CO (in ppm) and PSS.

<p>Relationship between exhaled CO (in ppm) and PSS.</p

Additional file 1: of Esmolol indirectly stimulates vagal nerve activity in endotoxemic pigs

Supplemental digital content. (DOCX 310 kb

Additional file 1: of Corticosteroids in septic shock: a systematic review and network meta-analysis

Summary tables of included and excluded study characteristics [47–60]. (DOCX 87 kb