Risky Journeys: The Development of Best Practice Adult Educational Programs to Indigenous People in Rural and Remote Communities

The findings from a culturally relevant innovative educational program to support community health through dog health are presented. It will report on the pilot of a program, using a generative curriculum model where Indigenous knowledge is brought into the process of teaching and learning by community members and is integrated with an empirical knowledge base. The characteristics of the pilot program will be discussed. These included locally relevant content, appropriate learning processes such as the development of personal caring relationships, and supporting different world views. Recommendations include the projected use of local Indigenous health workers to enhance the sustainability of the program

Torts

Covers cases on limitation of actions in malpractice suits, on the extent of liability for ultrahazardous activities (Furber), and on defenses available to the tortfeasor in wrongful death actions (Dixon)

Oklahoma State University Valedictorian Scholarship Program: Considering the Non-use of Act Score in Scholarship Selection Criteria

Valedictorian Scholarship recipients at Oklahoma State University are provided an annual tuition waiver of $1,250. The University's awarding criteria for the scholarship requires the student to only have been certified Valedictorian by the high school or school district. While other merit-based institutional scholarships at OSU require students to meet an ACT score of at least 24, the Valedictorian Scholarship program does not include ACT as part of the awarding process. It is possible for Valedictorian students with ACT scores <24 to receive Valedictorian Scholarship funding when the student would otherwise be excluded from institutional scholarship programs. Little evidence exists that suggests that academic honors such as Valedictorian predict post-secondary success, but OSU excludes ACT and defers to Valedictorian status when making scholarship award decisions. The purpose of this research was to determine if ACT scores of first-year Valedictorian Scholarship recipients are inconsequential. IndependSchool of Teaching and Curriculum Leadershi

Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis.

Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1(-/-) mice displayed ER stress and showed hallmarks of the unfolded protein response. In addition, loss of Miner1 caused a depletion of ER Ca(2+) stores, a dramatic increase in mitochondrial Ca(2+) load, increased reactive oxygen and nitrogen species, an increase in the GSSG/GSH and NAD(+)/NADH ratios, and an increase in the ADP/ATP ratio consistent with enhanced ATP utilization. Furthermore, mitochondria in fibroblasts lacking Miner1 displayed ultrastructural alterations, such as increased cristae density and punctate morphology, and an increase in O2 consumption. Treatment with the sulphydryl anti-oxidant N-acetylcysteine reversed the abnormalities in the Miner1 deficient cells, suggesting that sulphydryl reducing agents should be explored as a treatment for this rare genetic disease

An axiomatic approach to electromagnetic and gravitational radiation reaction of particles in curved spacetime

The problem of determining the electromagnetic and gravitational ``self-force'' on a particle in a curved spacetime is investigated using an axiomatic approach. In the electromagnetic case, our key postulate is a ``comparison axiom'', which states that whenever two particles of the same charge $e$ have the same magnitude of acceleration, the difference in their self-force is given by the ordinary Lorentz force of the difference in their (suitably compared) electromagnetic fields. We thereby derive an expression for the electromagnetic self-force which agrees with that of DeWitt and Brehme as corrected by Hobbs. Despite several important differences, our analysis of the gravitational self-force proceeds in close parallel with the electromagnetic case. In the gravitational case, our final expression for the (reduced order) equations of motion shows that the deviation from geodesic motion arises entirely from a ``tail term'', in agreement with recent results of Mino et al. Throughout the paper, we take the view that ``point particles'' do not make sense as fundamental objects, but that ``point particle equations of motion'' do make sense as means of encoding information about the motion of an extended body in the limit where not only the size but also the charge and mass of the body go to zero at a suitable rate. Plausibility arguments for the validity of our comparison axiom are given by considering the limiting behavior of the self-force on extended bodies.Comment: 37 pages, LaTeX with style package RevTeX 3.

Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types

Trans-plasma membrane electron transfer (tMPET) is a process by which reducing equivalents, either electrons or reductants like ascorbic acid, are exported to the extracellular environment by the cell. TPMET is involved in a number of physiological process and has been hypothesised to play a role in the redox regulation of cancer metabolism. Here, we use a new electrochemical assay to elucidate the ‘preference’ of cancer cells for different trans tPMET systems. This aids in proving a biochemical framework for the understanding of tPMET role, and for the development of novel tPMET-targeting therapeutics. We have delineated the mechanism of tPMET in 3 lung cancer cell models to show that the external electron transfer is orchestrated by ascorbate mediated shuttling via tPMET. In addition, the cells employ a different, non-shuttling-based mechanism based on direct electron transfer via Dcytb. Results from our investigations indicate that tPMETs are used differently, depending on the cell type. The data generated indicates that tPMETs may play a fundamental role in facilitation of energy reprogramming in malignant cells, whereby tPMETs are utilised to supply the necessary energy requirement when mitochondrial stress occurs. Our findings instruct a deeper understanding of tPMET systems, and show how different cancer cells may preferentially use distinguishable tPMET systems for cellular electron transfer processes

The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease

Lafora disease (LD) is a progressive myoclonic epilepsy resulting in severe neurodegeneration followed by death. A hallmark of LD is the accumulation of insoluble polyglucosans called Lafora bodies (LBs). LD is caused by mutations in the gene encoding the phosphatase laforin, which reportedly exists solely in vertebrates. We utilized a bioinformatics screen to identify laforin orthologues in five protists. These protists evolved from a progenitor red alga and synthesize an insoluble carbohydrate whose composition closely resembles LBs. Furthermore, we show that the kingdom Plantae, which lacks laforin, possesses a protein with laforin-like properties called starch excess 4 (SEX4). Mutations in the Arabidopsis thaliana SEX4 gene results in a starch excess phenotype reminiscent of LD. We demonstrate that Homo sapiens laforin complements the sex4 phenotype and propose that laforin and SEX4 are functional equivalents. Finally, we show that laforins and SEX4 dephosphorylate a complex carbohydrate and form the only family of phosphatases with this activity. These results provide a molecular explanation for the etiology of LD