Effect of hesperidin on renal complication in experimentally induced renal damage in diabetic sprague dawley rats

Present study was designed to evaluate in effect of Hesperidine on renal complication in Ischemia/reperfusion (I/R) induced renal damage in Sprague dawley diabetic rats. Hyperglycaemia is most probably a contributing factor in the development of ischaemic acute renal failure (ARF) in many patients. Both clinical and experimental data suggest that hyperglycaemia increases the risk of ARF. Type 2 Diabetes was induced in rats by a single intraperitoneal (i.p) injection of Streptozotocin (65 mg/kg, STZ) in overnight fasting rats followed by the i.p administration of Nicotinamide (110 mg/kg, NIC) after 15 minutes. After right nephrectomy, Hesperidine (100 mg/kg/day, p.o) was administered for 15 days. On the 16th day, ischemia was induced in contra lateral kidney for 45 min, followed by reperfusion for 24 hr. Renal function marker and oxidative parameter were estimated at the end of 24 hr reperfusion. At the end of experimental period the level of malondialdehyde formation/ lipid peroxidation (LPO) in kidney tissue and serum marker Creatinine, Urea and Uric acids were significantly increased. Whereas, the activity of biomarkers of oxidative stress such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) were found to be decreased significantly compared to control rats. Hesperidine improved the renal dysfunction and oxidative stress after renal ischemia/reperfusion injury in diabetic rats. In conclusion, Hesperidine shows potent may improve renal complication in I/R induced renal damage in type 2 diabetic rats.--------------------------------------------------------------------------------------------------------Pharmacology Department, Dharmaj Degree Pharmacy College, Petlad-Khambhat Road, Dharmaj, Anand-388430, Gujarat, India*Corresponding author, Email: [email protected]; Tel: +919825882522Cite This Article As: Jagdish Kakadiya, Divyang Patel, Nehal Shah. 2010. Effect of hesperidin on renal complication in experimentally induced renal damage in diabetic sprague dawley rats. J. Ecobiotechnol. 2(2): 45-50

Cardiac implantable electronic device lead extraction in patients with underlying infection using open thoracotomy or percutaneous techniques

Background: Explanting infected cardiac implantable electronic devices (CIEDs) and extracting their associated leads can be performed percutaneously (EP) or via open-thoracotomy (OR) approach. In this study, we examined the characteristics and outcomes of infected CIED patients undergoing EP vs. OR extraction procedures. Methods: All patients (EP: n = 329 and OR: n = 24) who received lead extraction in the presence of an infected CIED from 2005 to 2010 at the University of Pittsburgh Medical Center were included in this study. Demographic and clinical characteristics were obtained from the electronic medical records. The Charlson comorbidity index (CCI) was used to adjust for severity of co-morbid conditions. Results: Compared to the EP group, OR patients were more likely to have positive blood cultures, larger vegetations, and worse CCI scores. They also had higher total mortality rates at 1 (p = 0.036), 6 (p = 0.020), and 12 months (p = 0.012) after the procedure. One-year survival after lead extractions was significantly better for the EP compared to the OR group (p = 0.002) even after adjusting for other comorbid illnesses (HR = 2.6, p = 0.010) in a Cox regression model. Conclusions: Infected CIED patients undergoing open-chest lead extraction are sicker and have higher mortality rates compared to those undergoing percutaneous extraction. Randomized, prospective data are needed to determine whether the procedural strategy for lead extraction accounts in part for the difference in outcome.

Evaluation of Dabur Refined Coconut Oil In Comparison With Untraded Oil

ABSTRACT Oils are the most important lipids found in nature. They are one of the thr ee major 'food factor' needed for human body, the other two being proteins and carbohydrates. Oils are widely distributed in foods and are of great nutritional value. Coconut oil is also of great nutritional value and as well as therapeutic values. Many oils are available in the market with different brand name. These oils are variable in quality and some are liable to adulteration by cheaper varieties. It is not, as a rule, possible to judge the purity of oil by a determination of any one chemical constituents, and the evidence of quality is usually dependent upon determination of various tests such as refractive index, acid value, iodine value, saponification value, unsaponifiabl e matter, peroxide value, etc. In order to ensure the safety of consumer the concern authorities like who has prescribed some specification for coconut oil. Our evaluation studies on different brand of coconut oil shows that the quality of coconut oil manufacture by Dabur India Pvt. Ltd. is of superior quality than other branded and untraded locally available coconut oil

Mortality risk of long-term amiodarone therapy for atrial fibrillation patients without structural heart disease

Background: Amiodarone is often prescribed in the management of atrial fibrillation (AF) but is known to cause significant end-organ toxicities. In this study, we examined the impact of amiodarone on all-cause mortality in AF patients with structurally normal hearts. Methods: We performed a retrospective cohort analysis of all AF patients with structurally normal hearts who were prescribed antiarrhythmic drugs (AAD) for rhythm control of AF at our institution from 2006 to 2013 (n = 2,077). Baseline differences between the amiodarone (AMIO: n = 403) and other AADs (NON-AMIO: n = 1,674) groups were corrected for using propensity score matching. Results: Amiodarone use as first-line therapy decreased significantly with a higher degree of prescriber specialization in arrhythmia management (31%, 22%, and 9% for primary care physicians, general cardiologists and cardiac electrophysiologists, respectively, p < 0.001). After propensity score matching, baseline comorbidities were balanced between the AMIO and NON-AMIO groups. Over a median follow-up of 28.2 months (range 6.0–100.9 months), amiodarone was associated with increased all-cause (HR 2.41, p = 0.012) and non-cardiac (HR 3.55, p = 0.008) mortality, but not cardiac mortality. AF recurrence and cardiac hospi­talizations were similar between the two study groups. Conclusions: Amiodarone treatment of AF is associated with increased mortality in patients without structural heart disease and therefore should be avoided or only used as a second-line therapy, when other AF therapies fail. Adherence to guideline recommendations in the management of AF patients impacts clinical outcome

A community based cross sectional study of prevalence and risk factors of low birth weight

Introduction: Birth weight is an independent and an important factor that affects mortality, morbidity and growth and development during infancy and later life. India is accounting for 40% of the global Burdon of low birth weight babies. Multiple causative factors identified to be responsible for low birth weight. Aims & objectives: 1. To estimate the prevalence of low birth weight babies. 2. To study the association of maternal factors with birth weight. Method:The present community based cross sectional study conducted to among the urban population of Rajkot city and identify the determinants of low birth weight. Sampling population was selected by multistage sampling method. Investigator collected history of low birth weight and other determinants by verification of records and examination by house to house visit. Result:The prevalence of low birth was found 19.6. The factors like sex of the baby, birth order, birth spacing, maternal age, maternal education, regular antenatal check-up and mother’s weight gain during pregnancy were found significant determinants of LBW. Conclusion:The prevalence of low birth was high in urban area require multipronged strategy. The primary health care can diminish the determinant of the low birth weight by adequate birth interval, two-child norms, regular antenatal check-up, supplementary nutrition to mother, female literacy etc

Clinical Study of Type 2 Diabetes Mellitus Patients with or without Cerebrovascular Feature and Its Correlation with Other Comorbidity / Diabetic Complication

Introduction: Type 2 Diabetes Mellitus (T2DM) is rapidly emerging as a Global health problem, which may reach pandemic level by 2030. India is a global capital of Diabetes. Many long term complication may develop in T2DM patients. Cerebrovascular complications are one of the major cause of morbidity and mortality in T2DM. Aim: our aim of study to estimate the prevalence of cerebrovascular complication in diabetic and its association with other risk factors and/or diabetic complication. Materials and Methodology: This study was conducted retrospectively enrolling 100 diabetic patients, admitted in medical ward in our institute during January 2014 to September 2015. Results and Discussion: Out of 100 patients, 27 patients had Cerebrovascular Stroke. In this Cerebrovascular (CV) Stroke group, 37.04% had retinopathy, 55.55% had urinary albuminuria, 48.15 % had hypertension and 25.92% had cardiac involvement. Conclusion: Cerebrovascular complications are more prevalent in diabetic due to more likely atherosclerotic event. In this study, comorbidity like Retinopathy, Urinary Albuminuria, loss of Cortico-medullary differentiation (CMD), Hypertension and Cardiac involvement, this are the factor which has a more incidence in CV Stroke group than in group without neurological deficit. So, identification of risk factor and aggressive control of such factor is the most important part of the management of diabetes

Mesenchymal Stem Cell Conditioned Media Ameliorate Psoriasis Vulgaris: A Case Study

Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. In this report, we discuss our findings about a scalp psoriasis suffering patient with a Psoriasis Scalp Severity Index (PSSI) score of 28, who was treated with Mesenchymal stem cell conditioned media (MSC-CM). Remarkably, complete regression was recorded within a treatment period of one month only (PSSI score of 0). A number of bioactive factors like cytokines and growth factors secreted by MSCs in the conditioned medium are very likely to be the principle molecules which play a vital role in skin regeneration. Treatment using MSC-CM appears to be an effective tool for tackling the psoriatic problem and, thus, may offer a new avenue of therapy which could be considered as an alternative approach to overcome the limitations of the cell-based therapy