Signals of Leptophilic Dark Matter at the ILC

Adopting a model independent approach, we constrain the various effective interactions of leptophilic DM particle with the visible world from the WMAP and Planck data. The thermally averaged indirect DM annihilation cross-section and the DM-electron direct-detection cross-section for such a DM candidate are observed to be consistent with the respective experimental data. We study the production of cosmologically allowed leptophilic DM in association with $Z\, (Z\to f\bar f)$, $f\equiv q,\,e^-,\, \mu^-$ at the ILC. We perform the $\chi^2$ analysis and compute the 99\% C.L. acceptance contours in the $m_\chi$ and $\Lambda$ plane from the two dimensional differential distributions of various kinematic observables obtained after employing parton showering and hadronization to the simulated data. We observe that the dominant hadronic channel provides the best kinematic reach of 2.62 TeV ($m_\chi$ = 25 GeV), which further improves to 3.13 TeV for polarized beams at $\sqrt{s} = 1$ TeV and an integrated luminosity of 1 ab$^{-1}$.Comment: 17 pages, 10 figures, 5 table

Data-Driven Application Maintenance: Views from the Trenches

In this paper we present our experience during design, development, and pilot deployments of a data-driven machine learning based application maintenance solution. We implemented a proof of concept to address a spectrum of interrelated problems encountered in application maintenance projects including duplicate incident ticket identification, assignee recommendation, theme mining, and mapping of incidents to business processes. In the context of IT services, these problems are frequently encountered, yet there is a gap in bringing automation and optimization. Despite long-standing research around mining and analysis of software repositories, such research outputs are not adopted well in practice due to the constraints these solutions impose on the users. We discuss need for designing pragmatic solutions with low barriers to adoption and addressing right level of complexity of problems with respect to underlying business constraints and nature of data.Comment: Earlier version of paper appearing in proceedings of the 4th International Workshop on Software Engineering Research and Industrial Practice (SER&IP), IEEE Press, pp. 48-54, 201

Testing the dynamic origin of Quasi-periodic Oscillations in MAXI J1535-571 and H 1743-322

We investigate spectro-temporal properties for two black hole X-ray binary sources, MAXI J1535$-$571 and H 1743$-$322, during their hard and hard-intermediate states. For MAXI J1535$-$571, we analyze Swift/XRT, NuSTAR and NICER observations, specifically focusing on the occurrence of type-C Quasi-periodic Oscillations (QPOs). Regarding H 1743$-$322, we analyze multi-epoch observations of NICER and AstroSat, identifying a type-C QPO with centroid frequency ranging from 0.1--0.6 Hz. In both sources, we fit the spectra with a relativistic truncated disk and a power law component. In MAXI J1535$-$571, we also observe an additional relativistically smeared iron line. Through temporal and spectral analysis, we estimate the QPO centroid frequency and spectral parameters, such as the accretion rate and inner disc radii. We test the origin of type-C QPOs as relativistic precession frequency and dynamic frequency (i.e. the inverse of the sound crossing time $\frac{r}{c_s(r)}$). The dependence of QPO frequency on both the accretion rate and inner disc radii favours the QPO origin as dynamic frequency. We discuss the implications of these results.Comment: 12 pages, 7 figures, 4 tables, accepted for publication in MNRA

Spectropolarimetric study of 4U 1630−-47 in Steep Power law state with IXPE and NICER

We probe the spectropolarimetric properties of the black-hole binary source 4U 1630$-$47 in the steep power law state. We detect a significant polarization fraction of $\sim$7 % at a polarization angle of $\sim$21 $^\circ$. The $2-12$ keV NICER spectrum can be fitted with a combination of a thermal and a Comptonization component, the latter characterized by a spectral index, $\Gamma \sim$2.1, along with a reflection feature at $\sim$7.0 keV. In the $2-8$ keV band, the degree of polarization of 4U 1630$-$47 in the steep power law state is 4.4 $\sigma$ different from the value previously measured in the high soft state. In the steep power law state, the polarization fraction increases as a function of energy but exhibits an overall drop in each energy band compared to that of the high soft state. We propose that the decrease in the polarization fraction in the steep power law state could be attributed to the presence of a corona. The observed polarization properties in both states can be explained by the self-irradiation of the disk around a Kerr black hole, likely influenced by the frame-dragging effect.Comment: 6 pages, 7 figures, 3 tables, accepted for publication in MNRA

Unveiling the X-ray polarimetric properties of LMC X-3 with IXPE, NICER, and Swift/XRT

The incoming Imaging X-ray Polarimetry Explorer (IXPE) observations of X-ray binaries provide a new tool to investigate the underlying accretion geometry. Here we report the first measurements of X-ray polarization of the extra-galactic black-hole X-ray binary LMC X$-$3. We find a polarization fraction of $\sim$ 3 % at a polarization angle of $\sim 135^\circ$ in the $2-8$ keV energy band with statistical significance at the 7$\sigma$ level. This polarization measurement significantly exceeds the minimum detectable polarization threshold of 1.2 % for the source, ascertained at a 99 % confidence level within the $2-8$ keV energy band. The simultaneous spectro-polarimetric fitting of NICER, Swift/XRT, and IXPE revealed the presence of a disc with a temperature of 1 keV and a Comptonized component with a power-law index of 2.4, confirming the soft nature of the source. The polarization degree increases with energy from $\sim$3 % in the $2-5$ keV band to $\sim$8 % in the $5-8$ keV band, while the polarization angle is energy independent. The observed energy dependence and the sudden jump of polarization fraction at $\sim$ 5 keV supports the idea of a static slab coronal geometry for the comptonizing medium of LMC X$-$3. We further observed no change in the polarization properties with time over the period of the IXPE observations.Comment: 6 pages, 5 figures, 3 tables, submitted to MNRA

Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride

The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug

Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system

Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl

Design and in vitro evaluation of mouth dissolving tablets olanzapine

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets.  The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactor