Best and final glomerular filtration rate and time of assessment during the follow-up period.

<p>G1 - GFR ≥90; G2 - GFR ≥60 and <90; G3 - GFR ≥30 and <60; G4 - GFR ≥15 and <30 mL/min per 1.73 m². Classification based on the best glomerular filtration rate (GFR) achieved up to 18 months after discharge. P1: comparison among all the four groups; P2: comparison between G1+G2 and G3+G4 grouped.</p

Progression of the glomerular filtration rate from reference to 60 months after acute kidney injury for patients in groups G1 to G4.

<p>GFR: estimated glomerular filtration rate; m: months; ref: reference; AKI: lowest value during the acute kidney injury episode; discharge: hospital discharge. ×: patient progressed to ESRD. Δ: patient died.</p

Multiple variable logistic regression for being in G3 or G4 (reference: G1 and G2 grouped).

<p>The final model was adjusted for the following variables: diabetes, hypertension, dialysis and nephrotoxicity and hypovolemia etiologies. Hosmer-Lemenshow test had a P-value  = 0.853. G1 - GFR ≥90; G2 - GFR ≥60 and <90; G3 - GFR ≥30 and <60; G4 - GFR ≥15 and <30 mL/min per 1.73 m². Classification based on the best glomerular filtration rate (GFR) achieved up to 18 months after discharge. sCr : serum creatinine; OR: odds ratio; CI: 95% confidence interval.</p

Flowchart of patients included in the analysis.

<p>AKI: acute kidney injury; sCr: serum creatinine.</p

Comparison between reference and best GFR up to 18 months in all groups.

<p>GFR: estimated glomerular filtration rate.</p

Main characteristics of the four groups: demographic and clinical data.

<p>G1 - GFR ≥90; G2 - GFR ≥60 and <90; G3 - GFR ≥30 and <60; G4 - GFR ≥15 and <30 mL/min per 1.73 m². Classification based on the best glomerular filtration rate (GFR) achieved up to 18 months after discharge. P1: comparison among all the four groups; P2: comparison between G1+G2 and G3+G4 grouped.</p

Status of the patients in July 2010.

<p>G1 - GFR ≥90; G2 - GFR ≥60 and <90; G3 - GFR ≥30 and <60; G4 - GFR ≥15 and <30 mL/min per 1.73 m². Classification based on the best glomerular filtration rate (GFR) achieved up to 18 months after discharge.</p

Characteristics of the acute kidney injury episode.

<p>LOS: length of stay from acute kidney injury diagnosis to hospital discharge; sCr : serum creatinine; AKI: acute kidney injury; P1: comparison among all the four groups; P2: comparison between G1+G2 and G3+G4 grouped. G1 - GFR ≥90; G2 - GFR ≥60and<90; G3 - GFR ≥30 and <60; G4 - GFR ≥15 and <30 mL/min per 1.73 m². Classification based on the best glomerular filtration rate (GFR) achieved up to 18 months after discharge.</p

Flow-chart showing the selection process.

<p>CKD: chronic kidney disease Scr: serum creatinine.</p

Final Cox model.

<p>HR, Hazard ratio; CI, confidence interval; AKI, acute kidney injury.</p><p>Adjusted for: age, gender, presence of cancer, heart failure and presumed chronic kidney disease, septic and nephrotoxic etiologies.</p